DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and mamo

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster

Alignment Length:	823	Identity:	193/823 - (23%)
Similarity:	296/823 - (35%)	Gaps:	241/823 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 QHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDE-RSFTAHKVVLSACSPYFRRLLKANPCEH 139
            :||.|:||::||::|..|..|..:...|||||.|.| .|..||||||||||.||:.|...:|..|
  Fly     4 EHYCLRWNNYQSNLLGVFSQLLQDGSLVDVTLVCSEGTSIRAHKVVLSACSSYFQSLFLEHPEGH 68

  Fly   140 PIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKALSAALS 204
            .||||:|||..:::.|:.|||.|||||.:.||...||||..|:::|||::
  Fly    69 LIVILKDVRFAELQTLVEFMYKGEVNVQYCQLSALLKTAESLKVKGLAEM--------------- 118

  Fly   205 HNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHN 269
               :|.|....................:..|.|....|..:....:|| ..::.:.:...:::..
  Fly   119 ---TNQNTTLREPEREPDRLRPQGGGGSGGSAHKAADSPAAALDATAA-TQAATATATATAAAAT 179

  Fly   270 NSSSNNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSSAA 334
            ::|::..|.:..::..:..|         ||:.|.|||.:::.|...||...||.|:|.:|::|.
  Fly   180 STSTSATSAAATAAATAATS---------ASTTATAAAGSSNTTTTTAATTTATCATAATSTAAT 235

  Fly   335 SGQTSGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMGE-MEGSRKSHLTPPPQ-KRIKSAD 397
            |..:|.|.|.....|:::||.|.:.....|.:||:.    |: .|.|.:|..||..: .|:..||
  Fly   236 SSSSSVTSAAAAAAAAASASGVAHSEEATSSSSSTG----GQKREASDRSSPTPAKRSSRMHPAD 296

  Fly   398 LF-----RAQHGISPERLLL------------DREFPVAGQHPLTRNRSGRDTSKDRE------- 438
            ..     |.|.....:.||.            |.:.....::..|:.| |||...|.|
  Fly   297 KVDVAEDREQEQNQADELLSEELLGRNLKDEEDDDVDELDENEETKLR-GRDEDDDDEDEEEDTP 360

  Fly   439 --------RNLELRESLLGQALE--------------------NSNGQQANPKHELGQSAGEDSN 475
                    .|:|.:.:....|.:                    |||....|..:....:....|:
  Fly   361 MPLDLYQRPNVEPKSAAAATAAQQGGSNSLSGSSNACHTNSSSNSNNNNNNNNNSSSNNNNNTSS 425

  Fly   476 SSDTEPSDRGDGQHDGTLDGI--------DNQRSHSFPNAFLGLQGIPGLLPGPSGINSDFVSRR 532
            ...:..|:.|.....||.|.:        |:...|......:           ...:..| |...
  Fly   426 GKTSASSNGGTASSGGTADSVVAVDDDDDDDDGGHHHQRQVM-----------DDRLEQD-VDEE 478

  Fly   533 SLEMRVRATDPRPCPKCGKIYRSAH--TLRTHLEDKHTVCPGYRCVLCGTVAKSRNSLHSHMSRQ 595
            .|:..|....|......|...|.||  ..|.|....|              |:.::|.|.|...|
  Fly   479 DLDDDVVVVGPATAMARGIAQRLAHQNLQRLHHTHHH--------------AQHQHSQHHHPHSQ 529

  Fly   596 HR--------------------------------------------------GISTK-------- 602
            |.                                                  |::.|
  Fly   530 HHHTPHHQQHHTHSDDEDAMPVIAKSEILDDDYDDEMDLEDDDEADNSSNDLGLNMKMGSGGAGG 594

  Fly   603 ----DL---------PVLPMPSAFDPELASRLLAKAGVKISPAELRARASPTGGS----GSSGG- 649
                ||         |::.:||:.....|:...|....:.:||...|:|:..|.|    |..||
  Fly   595 GGGVDLSTGSTLIPSPLITLPSSSAAAAAAAAAAMESQRSTPAMSAAQAAGAGASDLSIGGCGGR 659

  Fly   650 -------------GGGGGSSQAKL-------DLSNASGGPMD---DAEDSDDD---------PED 682
                         ||.||:|.:.|       :|......|:.   :.:.|:||         ...
  Fly   660 PASRSSRDGGGNDGGRGGASSSSLLSPGTVANLLPVQSVPLSLKKEIDCSEDDNSSHSRHMQQRS 724

  Fly   683 LTTGNGLYGMGGSSSDLSRYHESLLSNFGHARMRNEAAAVAAT 725
            .:.|.||    |...|....|||||.||.     :..:|:||:
  Fly   725 ASAGGGL----GGDLDYRASHESLLRNFS-----SPMSAMAAS 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	51/96 (53%)
		BTB	104..189	CDD:197585	48/85 (56%)
		zf-Di19	545..597	CDD:283297	12/53 (23%)
		C2H2 Zn finger	546..567	CDD:275371	6/22 (27%)
		C2H2 Zn finger	575..596	CDD:275371	4/20 (20%)
mamo	NP_572932.2	BTB	21..118	CDD:279045	51/96 (53%)
		BTB	32..118	CDD:197585	48/85 (56%)
		C2H2 Zn finger	1082..1105	CDD:275368
		C2H2 Zn finger	1116..1137	CDD:275368
		C2H2 Zn finger	1149..1169	CDD:275368
		zf-C2H2	1469..1491	CDD:278523
		C2H2 Zn finger	1471..1491	CDD:275368
		zf-H2C2_2	1483..1506	CDD:290200
		C2H2 Zn finger	1499..1519	CDD:275368
		zf-H2C2_2	1511..1536	CDD:290200
		C2H2 Zn finger	1527..1547	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451881
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.940