DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and CG32121

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001097599.1	Gene:	CG32121 / 317867	FlyBaseID:	FBgn0052121	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	730	Identity:	174/730 - (23%)
Similarity:	261/730 - (35%)	Gaps:	182/730 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 QQQQH---QQHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRL 131
            ||.||   ||.:.|:|::.|:|:||:...|.|:....|||::.:.|...||:|||||||.:|..:
  Fly    19 QQLQHNDSQQQFCLRWHNHQTSLLSTLPILLDQSHLTDVTISAEGRQLRAHRVVLSACSSFFMDI 83

  Fly   132 LKA-NPCEHPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPY 195
            .:| ....||::|:.......:.:||:|||:|||||..||:|..|..|..|.|:|||||
  Fly    84 FRALEASNHPVIIIPGASFGAIVSLLTFMYSGEVNVYEEQIPMLLNLAETLGIKGLADV------ 142

  Fly   196 SKALSAALSHNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSN 260
                           .|||..........:..:..|.:||...:.:   :|:.|.......|::.
  Fly   143 ---------------QNNNLPKTARSGGGSYMDTTNEKSSEFERPT---TPSPTPTPTLTPSHTP 189

  Fly   261 SNNH--------SSSHNNSSSNNISGSLNSS------LNSPFSAPQ-----IPPPVTASSAA--A 304
            :.:|        |::.|.....|..||:|||      |.:.|.:.|     :|.|:..|..|  .
  Fly   190 TPSHSLPLPQLPSAALNTPLLANKLGSVNSSGMGTTPLENLFKSLQFYPSLLPQPLNFSQTALNK 254

  Fly   305 AAAAAASLTAAVAAAAAATAASAGSSSSAASGQTSGTPAIQELK-----------------ASSA 352
            .....|..........:........:....|.:..|....:||:                 :||:
  Fly   255 TTELLAKYQQQCQLYQSGMQEDQLETDCFGSKRLKGDSPPKELRRLEKSLLKNPKSSSTTNSSSS 319

  Fly   353 ASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTPP-PQKRIKSADLFRAQHGISPERLLLDREF 416
            .||....||||..|:|.     ..:.....:|.:|. |..:..||                  .:
  Fly   320 KSPQECSNPNPIVATSP-----VTLAPPTMAHFSPQLPVVKCSSA------------------SY 361

  Fly   417 PVA-GQHPLTRNRSGRDTSKDRERNLELRESLLGQALENSNGQQANPKHELGQSAGEDSNSSDTE 480
            |.| ||..|..:                :..|...|:..:..|||...|...|..
  Fly   362 PSALGQGQLYSS----------------KPPLYSAAVTPTAAQQAAQMHHHPQPG---------- 400

  Fly   481 PSDRGDGQHDGTLDGIDNQRSHSFPNAFLGLQGIPGLLPGPSGINSDFVSRRSLEMRVRATDPRP 545
            ||.....:....|.....|.......|.....|...|:...|..|  .:|..:...:..||.|..
  Fly   401 PSPYISAEDHAKLQLHIEQYQREAAAAAAAAAGGMALVSAKSEPN--LLSLSADRDKSLATAPIK 463

  Fly   546 CPKCGKIYRSA----------HTLRTHLEDKHTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGIS 600
            .|...|:|.:.          :.||.|||....|  .|.|.:|..|::|:::|..|:|.:|.|
  Fly   464 PPSNSKLYATCFICHKQLSNQYNLRVHLETHQNV--RYACNVCSHVSRSKDALRKHVSYRHPG-- 524

  Fly   601 TKDLPVLPMPSAFDPELASRLLAKAGVKISPAE--LRARASPTGGSGSSGGGGGGGSSQAKLDLS 663
                    .||..:.|...:.::|......|..  :...||.|..||..|
  Fly   525 --------APSPCENEARRKRVSKLAATTVPTSTPMSMSASHTVTSGDVG--------------- 566

  Fly   664 NASGGPMDDAEDSDDDPEDLTTGNGLYGMGGSSSDLSRYHESLLSNFGHARMRNEAAAVAATAAA 728
                            |...||      :|.|..:....:..|.:.|..|... .|.|||.::.|
  Fly   567 ----------------PAPATT------LGCSGQEARNPYLFLPNQFQMAAAA-AAVAVAESSPA 608

  Fly   729 LGQPK-DLGVQLPNS 742
            .|||. ||..:.|.|
  Fly   609 SGQPSLDLAHEAPPS 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	40/96 (42%)
		BTB	104..189	CDD:197585	38/85 (45%)
		zf-Di19	545..597	CDD:283297	17/61 (28%)
		C2H2 Zn finger	546..567	CDD:275371	8/30 (27%)
		C2H2 Zn finger	575..596	CDD:275371	7/20 (35%)
CG32121	NP_001097599.1	BTB	48..142	CDD:279045	40/93 (43%)
		BTB	56..149	CDD:197585	43/113 (38%)
		C2H2 Zn finger	474..494	CDD:275370	5/19 (26%)
		C2H2 Zn finger	501..518	CDD:275370	5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451889
Domainoid	1	1.000	69	1.000	Domainoid score	I9606
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.950