DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and CG3726

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	701	Identity:	159/701 - (22%)
Similarity:	244/701 - (34%)	Gaps:	233/701 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 QHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEH- 139
            |.|.|:|....|::.:.|..|.|...|.||||||:.:...||:|||.|||.:|..:|.....|.
  Fly     4 QQYCLRWKYHHSNLQTMFSQLLDRGCFCDVTLACEGQLIRAHRVVLCACSTFFDAVLSNYASERD 68

  Fly   140 PIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADV-----NGGYPYSKAL 199
            ||:|::||...:|:.|:.|||.||:||.|..||..||||..|:|:|||:|     ..|.|  ..:
  Fly    69 PIIIMKDVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWRDDEDGPP--PPM 131

  Fly   200 SAALSHNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNH 264
            :||..|          |...||          |||...:.|..:....|...|.     ...|.|
  Fly   132 AAAEFH----------SPPRSL----------AESYAQDLILQHQQQQQQGPAA-----PPLNLH 171

  Fly   265 SSS-----HNNSSSNNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATA 324
            ||:     ............|:..:........:..|:|
  Fly   172 SSAALLERDRERERERDRERLSPGMEGVLGRMPVMTPLT-------------------------- 210

  Fly   325 ASAGSSSSAASGQTSGTPAIQELKASSAASPVRN---PNPNPSKASSSNHWDM----------GE 376
               |:|.||..|..||..:::      ..:||.:   |.....:....:.:|:          ..
  Fly   211 ---GASGSAGVGSVSGGTSLE------GVAPVEHFLGPKRKRGRPPLDDAYDVFNVRKLAQYAAN 266

  Fly   377 MEGSRKSHL-------------------------TPPPQKRIKSADLFRAQHGISPERLLL---- 412
            :|.:::::|                         .||.|::       |.:|....::.||
  Fly   267 LEPAQRAYLETARHFTEEPPLAAHAASMASPPAACPPKQRQ-------RLRHQQQQQQQLLQSES 324

  Fly   413 -DREFPVAGQHPLTRNRSGRDTSK---DRERNLELRESLLGQALENSNGQQANPKHELGQSAGED 473
             |:|.|.|||.......:|..|.|   |.:.|.:          |...|.::.|      :....
  Fly   325 SDQEQPAAGQDWSNLEPNGSATPKLLSDGDANKQ----------ETEGGDESLP------AVLTT 373

  Fly   474 SNSSDTEPSDR--------GDGQHDGTL------DGIDNQRSHSFPNAFLGLQGIPGLLPGP-SG 523
            ::||.|:..::        |..:|...|      |.:|..:..            |..||.| ..
  Fly   374 ASSSGTKKLEKIGERRERHGKLRHARRLYEKSGEDEVDPPKEE------------PDELPQPVEE 426

  Fly   524 INSDFVSRRSLEMRVRATDPRPCPKCGKIYRSAHTLRTHLEDKHTVCP-GYRCVLCGTVAKS--- 584
            |.::.:      :..||..|||.                     .|.| .:.|...|.|..:
  Fly   427 IENEHL------VANRAESPRPT---------------------VVIPASFACKYEGGVTAAGGG 464

  Fly   585 ------RNSL-HSHMSRQHRGISTKDLPVLPMPSAFDPELASRLLAKAGVKISPAELRARASPTG 642
                  ..|| .|::..:|.         :.|...|.|.:|| ..|.|.|.:: |...|.|:.:.
  Fly   465 SGSGTGSGSLGSSYLINEHG---------MLMAHEFAPNVAS-AAATAAVAVA-AAAAAVANASA 518

  Fly   643 GSGSSG----GGGGGGSSQ-----------AKLDLSNASGGPMDDAEDSDD 678
            |:|:.|    |.|.|.::.           |:|.|:|.......|....||
  Fly   519 GNGNGGQDVSGSGTGAAADYPDIKLEDYDAAELRLTNEELSQWQDVIKMDD 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	47/96 (49%)
		BTB	104..189	CDD:197585	43/85 (51%)
		zf-Di19	545..597	CDD:283297	9/62 (15%)
		C2H2 Zn finger	546..567	CDD:275371	0/20 (0%)
		C2H2 Zn finger	575..596	CDD:275371	6/30 (20%)
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	47/96 (49%)
		BTB	32..121	CDD:197585	44/88 (50%)
		HTH_psq	587..622	CDD:283007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451899
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.950