DRSC/TRiP Functional Genomics Resources

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Protein Alignment ab and Hic2

DIOPT Version :9

Sequence 1:NP_476562.1 Gene:ab / 34560 FlyBaseID:FBgn0264442 Length:904 Species:Drosophila melanogaster
Sequence 2:NP_001099332.1 Gene:Hic2 / 287940 RGDID:1305338 Length:622 Species:Rattus norvegicus


Alignment Length:655 Identity:135/655 - (20%)
Similarity:213/655 - (32%) Gaps:228/655 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 PSLNL-SHQQQQHQQHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSP 126
            |.:.| ||.:|                :|......|.:....||.:..:...|.|||.||:|.|.
  Rat    21 PDMELPSHSKQ----------------LLLQLNQQRAKGFLCDVIIMVENSIFRAHKNVLAASSI 69

  Fly   127 YFRRLLKANPCEHPIVILRD---VRCDDVENLLSFMYNGEV----------------NVSHEQLP 172
            ||:.|:.     |..:|..|   |.....:.:|.|:|.|::                ..|:.|||
  Rat    70 YFKSLVL-----HDNLINLDTDMVSSTVFQQILDFIYTGKLLPGDQPSEPNFSTLLTAASYLQLP 129

  Fly   173 DF---------------------------------LKTAHLLQIR--GLADVNGGYPYSKALSAA 202
            :.                                 |.||.::|.|  ||.|...|:|..:.|..|
  Rat   130 ELAALCRRKLKRAGKPFGPGRVGTAGMGRPTRSQRLSTASVIQARYPGLVDGRKGHPAPQELPQA 194

  Fly   203 LSHNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSS 267
                        ..|::.|...::..    ||::...:....:.......|:.|:|.:       
  Rat   195 ------------KGSDDELFLGSSTQ----ESTHGLGLGGPAAGEVGLGGCSTSTNGS------- 236

  Fly   268 HNNSSSNNISGSLNSSLNSPFS--APQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSS 330
                     ||.....|....|  :|.:||                 |..|........|....|
  Rat   237 ---------SGGCEQELGLDLSKKSPPLPP-----------------TTPVPHLTPEDPAQLSDS 275

  Fly   331 SSAASGQTSGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMG-------EMEGSRKSHLTPP 388
            ...:...|           |::|.||.|         |:::.::|       ::||:.::||:  
  Rat   276 QRESPPPT-----------STSALPVSN---------STSYVELGATPDEPMDLEGAEENHLS-- 318

  Fly   389 PQKRIKSADLFRAQHGISPERLL--------LDREFPVAGQHPLTRNRSGRDTS---------KD 436
                     |...|.| .|.:.|        .:::.||||. |..|..:|..:|         .|
  Rat   319 ---------LLEGQGG-QPRKSLRHSARKKDWNKKEPVAGS-PFDRRETGSKSSCPGEEGEAPGD 372

  Fly   437 RERNLELRESLLGQA-LENSNGQQANP---KHELGQSAGEDSNSSDTEPSDRGDGQHDGTLDGID 497
            |..|..|..|..|.. ...|.|:...|   :.|.|:...|||..|.:|    |...|.|....:.
  Rat   373 RVPNGVLASSAGGGGPSAPSYGEPPYPCKEEEENGKDVSEDSGQSGSE----GGSGHTGGAHYVY 433

  Fly   498 NQRSHSF----PNAFLGLQGIPGLLPGPSGINSDFVSRRSLEMRVR------------------- 539
            .|..:..    .|.::.:....| .|....:|:...:....|:.::                   
  Rat   434 RQEGYETVSYGDNLYVCIPCAKG-FPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDL 497

  Fly   540 --------ATDPRP--CPKCGKIYRSAHTLRTHLEDKHTVCPGYRCVLCGTVAKSRNSLHSHMSR 594
                    |.:|||  |..|.|.|:...|||.| |..|.:...:.|.:||.:...|.::..|| |
  Rat   498 STPSSTAYAAEPRPFKCSVCEKTYKDPATLRQH-EKTHWLTRPFPCNICGKMFTQRGTMTRHM-R 560

  Fly   595 QHRGI 599
            .|.|:
  Rat   561 SHLGL 565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
abNP_476562.1 BTB 93..189 CDD:279045 33/149 (22%)
BTB 104..189 CDD:197585 32/138 (23%)
zf-Di19 545..597 CDD:283297 18/53 (34%)
C2H2 Zn finger 546..567 CDD:275371 9/20 (45%)
C2H2 Zn finger 575..596 CDD:275371 7/20 (35%)
Hic2NP_001099332.1 BTB_POZ 25..144 CDD:365784 31/139 (22%)
C2H2 Zn finger 450..470 CDD:275368 3/20 (15%)
SUF4-like 510..>559 CDD:411020 16/49 (33%)
C2H2 Zn finger 514..534 CDD:411020 9/20 (45%)
C2H2 Zn finger 514..534 CDD:275368 9/20 (45%)
zf-C2H2 540..562 CDD:395048 7/22 (32%)
C2H2 Zn finger 542..562 CDD:275368 7/20 (35%)
C2H2 Zn finger 542..559 CDD:411020 4/16 (25%)
zf-C2H2 568..590 CDD:395048
C2H2 Zn finger 570..590 CDD:275368
zf-H2C2_2 582..607 CDD:404364
C2H2 Zn finger 598..618 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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