DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and Trl

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001261846.1	Gene:	Trl / 2768981	FlyBaseID:	FBgn0013263	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	180/799 - (22%)
Similarity:	261/799 - (32%)	Gaps:	259/799 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 YALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIV 142
            |:|.|.|:.:|::|:.:.||...|.||.|||...|||.|||:||.|.||:...|||..||:||:|
  Fly     9 YSLTWGDYGTSLVSAIQLLRCHGDLVDCTLAAGGRSFPAHKIVLCAASPFLLDLLKNTPCKHPVV 73

  Fly   143 ILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKALSAALSHNS 207
            :|..|..:|:|.||.|:|.|||:|.|.|||..|:.|..|.|:|||.
  Fly    74 MLAGVNANDLEALLEFVYRGEVSVDHAQLPSLLQAAQCLNIQGLAP------------------- 119

  Fly   208 SNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNNSS 272
                                                    ||....:.:::|....|....::..
  Fly   120 ----------------------------------------QTVTKDDYTTHSIQLQHMIPQHHDQ 144

  Fly   273 SNNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSSAASGQ 337
            ...|:        :..:|||  ..|.|............|.|.....||....:..::.:|...|
  Fly   145 DQLIA--------TIATAPQ--QTVHAQVVEDIHHQGQILQATTQTNAAGQQQTIVTTDAAKHDQ 199

  Fly   338 TSGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTPPPQKRIKSADLFRAQ 402
            .    .||      |..|.|...|...|.|.                 |.|...:::..|..
  Fly   200 A----VIQ------AFLPARKRKPRVKKMSP-----------------TAPKISKVEGMDTI--- 234

  Fly   403 HGISPERLLLDREFPVAGQHPLTRNRSGRDTSKDRERNLELRESLLGQALENSNGQQANPKHELG 467
                                      .|..||                    |:| ..:.:..||
  Fly   235 --------------------------MGTPTS--------------------SHG-SGSVQQVLG 252

  Fly   468 QSAGEDSNSSDTEPSDRGDGQHDGTLDGID--NQRSHSFPNAFLG----LQGIPGLLPG-PSGIN 525
            ::..|....|.| |..:.:||...|:..:|  |....:..||..|    .||..|...| .||:.
  Fly   253 ENGAEGQLLSST-PIIKSEGQKVETIVTMDPNNMIPVTSANAATGEITPAQGATGSSGGNTSGVL 316

  Fly   526 SDFVSRRSL--------EMRVRATDPRPCPKCGKIYRSAHTLRTHLEDKHTVCPGYRCVLCGTVA 582
            |...::|:.        ..|.::..|..||.|..:.|.:..||.|||.:|...||        |.
  Fly   317 STPKAKRAKHPPGTEKPRSRSQSEQPATCPICYAVIRQSRNLRRHLELRHFAKPG--------VK 373

  Fly   583 KSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPELASRLLAKAGVKISPAELRARA---SPTGGS 644
            |.:.|                      .|..|..|.|.:           |:...|   :..|..
  Fly   374 KEKKS----------------------KSGNDTTLDSSM-----------EMNTTAEGDNTVGSD 405

  Fly   645 GSSGGGGGGGSSQAKLDLSNASG--GPMDDAEDSDDDPEDLTTGNGLYGMGG----SSSDLSRYH 703
            |:.|.|..||.|.|.....::||  |....|..|......:.|...|:.:.|    ...|..:..
  Fly   406 GAGGAGSAGGQSSATSGKKSSSGSSGSGSGALSSSGSVPQVQTVQSLHTLQGVQVKKDPDAQQQQ 470

  Fly   704 ESLLSNFGHARMRNEAAAVAATAAALGQPKDLGVQLPNSNAPGQ-------------SLLDTYLQ 755
            :.....    :.:.:..|:..:.|..||.:....|:.......|             .::|:...
  Fly   471 QQQQQQ----QQQQQQQAMTVSGATGGQVQQQVQQVQQQVQQQQQQQQQQQQQLQHHQIIDSSGN 531

  Fly   756 FITENTFGMGMSQEQAAAAALRAKMAQLNAMGHSLDNLPPGLLPGQFDLSKLAAGNPAFGQSGPG 820
            ..|..|      ..|||||      ||..|.|....      |..|.|.|          :||..
  Fly   532 ITTATT------SAQAAAA------AQQQAAGQQQQ------LVAQSDGS----------ESGAP 568

  Fly   821 LTIEPI--MRHEQAAGNLS 837
            |:|..:  ::..|..|||:
  Fly   569 LSIAQVQTLQGHQIIGNLN 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	50/95 (53%)
		BTB	104..189	CDD:197585	46/84 (55%)
		zf-Di19	545..597	CDD:283297	15/51 (29%)
		C2H2 Zn finger	546..567	CDD:275371	9/20 (45%)
		C2H2 Zn finger	575..596	CDD:275371	3/20 (15%)
Trl	NP_001261846.1	BTB	27..117	CDD:279045	47/89 (53%)
		BTB	35..118	CDD:197585	44/82 (54%)
		GAGA	319..372	CDD:150045	15/60 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010