DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ab and Zbtb37

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001343418.1	Gene:	Zbtb37 / 240869	MGIID:	2444467	Length:	504	Species:	Mus musculus

Alignment Length:	608	Identity:	134/608 - (22%)
Similarity:	209/608 - (34%)	Gaps:	162/608 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 DFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIVILRDVR 148
            ||.:|:||....||.:....|:.:....::|.||||||:|.|||||..:..|  |...|.:..::
Mouse    15 DFSNSVLSHLNQLRMQGRLCDIVVNVQGQAFRAHKVVLAASSPYFRDHMSLN--EMSTVSISVIK 77

  Fly   149 CDDV-ENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLAD----VNGGYPYS---KALSAALSH 205
            ...| |.||||.|.|.:.:....:..:|..|..||::.:.|    :..|..:.   ..:.|.||.
Mouse    78 NPTVFEQLLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILEGIHFKINVAEVEAELSQ 142

  Fly   206 NSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNN 270
            ..:.:......|:.:..|.|.:                |||                     .:|
Mouse   143 TRTKHQERPPESHRATPNLNRS----------------LSP---------------------RHN 170

  Fly   271 SSSNNISGSLNSSLN----SPFSAPQIPPPVTASSAAAAAAAAASLTAA----VAAAAAATAASA 327
            :|..|..|.:::.|:    ||...|..|..:..||.|........:..|    |....|...|.:
Mouse   171 ASKGNWRGQVSAVLDIRELSPPEEPTSPQIIEQSSDAEGREPILRINRAGQWYVETGLADQGARS 235

  Fly   328 GSSSSAASGQTSGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTPPPQKR 392
            |............|..::|.         ..|...||          || :||....:|
Mouse   236 GDEVRVLGAVHIKTENLEEW---------LGPENQPS----------GE-DGSSAEEVT------ 274

  Fly   393 IKSADLFRAQHGISPERLLLDREFPVAGQHPLTRNRSG----RDTSKDRER--------NLELRE 445
              :..:....||             ..||...|...||    |.||.:.:|        ::..|.
Mouse   275 --AMVIDTTGHG-------------SIGQESYTLGSSGAKVARPTSSEVDRFSPSGSVVSMTERH 324

  Fly   446 SLLGQALENSNGQQANPKHELGQSAGEDSNSS---------DTEPSDRGDGQHDGTLDGIDNQRS 501
                :|...|.|:...|| :|.....|.:...         :.|.|:|. .:::..|..|...:|
Mouse   325 ----RARSESPGRMDEPK-QLSSQVEESAMMGVSAYVEYLREQEVSERW-FRYNPRLTCIYCAKS 383

  Fly   502 HSFPNAFLGLQGIPGLLPGPSGINSDFVSRRSLEMRVR---ATDPRPCPKCGKIYRSAHTLRTHL 563
                                      |..:.||:..:|   ...|..|..|||.|.....|..|:
Mouse   384 --------------------------FNQKGSLDRHMRLHMGITPFVCRMCGKKYTRKDQLEYHI 422

  Fly   564 EDKHTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPELASRLLAKAGVK 628
            . |||....:.|.:||.....:..|:.|..:.|.|.    :| |..|.:..||  :.:.::...:
Mouse   423 R-KHTGNKPFHCHVCGKSFPFQAILNQHFRKNHPGC----IP-LEGPHSISPE--TTVTSRQAEE 479

  Fly   629 ISPA--ELRARASPTGGSGSSGG 649
            .||:  |:.|......||.|:.|
Mouse   480 GSPSHEEIVAPGESAQGSVSTTG 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	32/100 (32%)
		BTB	104..189	CDD:197585	30/89 (34%)
		zf-Di19	545..597	CDD:283297	15/51 (29%)
		C2H2 Zn finger	546..567	CDD:275371	7/20 (35%)
		C2H2 Zn finger	575..596	CDD:275371	5/20 (25%)
Zbtb37	NP_001343418.1	BTB_POZ_ZBTB37	9..131	CDD:349531	38/117 (32%)
		C2H2 Zn finger	377..397	CDD:275368	6/45 (13%)
		zf-H2C2_2	389..414	CDD:404364	9/24 (38%)
		zf-C2H2	403..425	CDD:395048	7/22 (32%)
		C2H2 Zn finger	405..425	CDD:275368	7/20 (35%)
		zf-H2C2_2	418..440	CDD:404364	8/22 (36%)
		C2H2 Zn finger	433..451	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S11797
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860