DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and Zbtb7b

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001342135.1	Gene:	Zbtb7b / 22724	MGIID:	102755	Length:	607	Species:	Mus musculus

Alignment Length:	758	Identity:	139/758 - (18%)
Similarity:	217/758 - (28%)	Gaps:	267/758 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SLTMAATGSALSPATPPP--SLNLSHQQQ---------QHQQHYALKWNDFQSSILSSFRHLRDE 99
            |||..|.||...|:.|.|  :..||...:         .......:.:.|..|.:||.....|..
Mouse    29 SLTPTAPGSNQLPSPPSPFVACGLSSPPRPPGSEKMGSPEDDLIGIPFPDHSSELLSCLNEQRQL 93

  Fly   100 EDFVDVTLACDERSFTAHKVVLSACSPYFRRLLK---------------------ANPCEHPIVI 143
            ....|:|:......:..|:.||:|||.||::|..                     |..||
Mouse    94 GHLCDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGTVMGTGGGGTASGGAGAGVCE----- 153

  Fly   144 LRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKALSAALSHNSS 208
            |..|..:.:..||.|.|...:..|...:|..|:.|.||:|            ...::|.:
Mouse   154 LDFVGPEALGALLEFAYTATLTTSSANMPAVLQAARLLEI------------PCVIAACM----- 201

  Fly   209 NNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNNSSS 273
                       .:...:.....:.:..:..:...||....|:                    :::
Mouse   202 -----------EILQGSGLEAPSPDEDDCERARQYLEAFATA--------------------TTT 235

  Fly   274 NNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSSAASGQT 338
            .:.||..|.. :||...|.:|||
Mouse   236 ASTSGMPNGE-DSPPQVPLLPPP------------------------------------------ 257

  Fly   339 SGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTPPPQKRIKSADLFRAQH 403
                       .....||...:..|.||       ..:.:|:|.:||.|
Mouse   258 -----------PPPPRPVARRSRKPRKA-------FLQTKGARANHLVP---------------- 288

  Fly   404 GISPERLLLDREFPVAGQHPLTRNRSGRDTSKDRERNLELRESLLGQALENSNGQQANPKHELGQ 468
                       |.|....||||..                .|.::|:               ||.
Mouse   289 -----------EAPTVLTHPLTYE----------------EEEMVGR---------------LGN 311

  Fly   469 SAGE---DSNSSDTEPSDRGDGQ-HDGTLDGIDNQRSHSFPNAF-LGLQGIPGLLPGPSGINSDF 528
            |.|.   ||.|..|..:...:|. :....:|.:.:...::|..: |.....|.|.|...|.:.|.
Mouse   312 SGGSGLGDSYSPPTGAASPAEGPLNYEVFEGEEEEEEMAYPPGYGLAQSNEPSLSPEELGSDEDP 376

  Fly   529 V---------------------SRRSLEMRVRATDPRPCPKCGKIYRSAHTLRTHLEDKHTVCPG 572
            :                     .:..|..:.|:..|:.||.|.||...|..|..|:. .||....
Mouse   377 IDPDLMAYLSSLHQDALTPGLDGQDKLVRKRRSQMPQECPVCHKIIHGAGKLPRHMR-THTGEKP 440

  Fly   573 YRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPELASRLLAKAGVKISPAELRAR 637
            :.|.:||......:.|..|| |:|.|......|..|.......:|.:.:....|.:.....|..:
Mouse   441 FACEVCGVRFTRNDKLKIHM-RKHTGERPYSCPHCPARFLHSYDLKNHMHLHTGDRPYECHLCHK 504

  Fly   638 ASPTGGSGSSGGGGGGGSSQAKLD-----LSNASGGPMDDAEDSDDD------PEDLTTGNGLYG 691
            |.                  ||.|     |...:...:.......||      |...||.:...|
Mouse   505 AF------------------AKEDHLQRHLKGQNCLEVRTRRRRKDDVAAPHYPPPSTTTSSPAG 551

  Fly   692 MGGSSSDLSRYHESLLSNFGHARMRNEAAAVAATAAALGQPKD 734
            :..|:..|..:|.||      ||...::|.........|.|::
Mouse   552 LDLSNGHLDTFHLSL------ARFWEQSATTGPPVTTQGPPEE 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	28/116 (24%)
		BTB	104..189	CDD:197585	27/105 (26%)
		zf-Di19	545..597	CDD:283297	17/51 (33%)
		C2H2 Zn finger	546..567	CDD:275371	8/20 (40%)
		C2H2 Zn finger	575..596	CDD:275371	7/20 (35%)
Zbtb7b	NP_001342135.1	BTB	87..207	CDD:306997	29/152 (19%)
		COG5048	412..>491	CDD:227381	23/80 (29%)
		C2H2 Zn finger	415..435	CDD:275368	8/20 (40%)
		zf-H2C2_2	430..452	CDD:316026	6/22 (27%)
		C2H2 Zn finger	443..463	CDD:275368	7/20 (35%)
		C2H2 Zn finger	471..491	CDD:275368	3/19 (16%)
		zf-H2C2_2	483..508	CDD:316026	4/42 (10%)
		C2H2 Zn finger	499..517	CDD:275368	5/35 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000