DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and Zbtb7a

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	XP_006513342.3	Gene:	Zbtb7a / 16969	MGIID:	1335091	Length:	725	Species:	Mus musculus

Alignment Length:	730	Identity:	154/730 - (21%)
Similarity:	238/730 - (32%)	Gaps:	225/730 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AGVVKMEPPPPATSSVSVSAAAAAHALSSLSSLTMAATGSALSPATPPPSLNLSHQQQQHQQHYA 79
            |..|:..||    ||..:|....:....||.|..||  |....|...|
Mouse   127 AAPVRAGPP----SSADISRPCKSSPGGSLVSRKMA--GGVDGPIGIP----------------- 168

  Fly    80 LKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPC--EHPIV 142
              :.|..|.|||.....|.:....||.:..:.|.|..|:.||:|||.||::|..:...  :..:.
Mouse   169 --FPDHSSDILSGLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVY 231

  Fly   143 ILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKALSAALSHNS 207
            .:..|..:.:..|:.|.|...:.||...:.|.|..|.||:|..::.|.......:.|:|
Mouse   232 EIDFVSAEALTALMDFAYTATLTVSTANVGDILSAARLLEIPAVSHVCADLLERQILAA------ 290

  Fly   208 SNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNNSS 272
              ::..::|..:.....:..|...|:        .||          ....||..|
Mouse   291 --DDVGDASQPDGAGPTDQRNLLRAK--------EYL----------EFFRSNPMN--------- 326

  Fly   273 SNNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSSAASGQ 337
                               .:||  ||...:...|....|.|...|.|||.||       .|:|.
Mouse   327 -------------------SLPP--TAFPWSGFGAPDDDLDATKEAVAAAVAA-------VAAGD 363

  Fly   338 TSGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTPPPQKRIKSADLFRAQ 402
            .:|.             ....|.| |:....:...|.|:.        ||
Mouse   364 CNGL-------------DFYGPGP-PADRPPAGDGDEGDS--------TP--------------- 391

  Fly   403 HGISPERLLLDREFPVAGQHP-------LTRN----RSGRDTSKDRERNL-----ELRES--LLG 449
             |:.|||   |.:.|..|..|       .|:|    |:|..|.::....|     |..:|  .|.
Mouse   392 -GLWPER---DEDAPPGGLFPPPTAPPATTQNGHYGRAGAGTGEEEAAALSEAAPEPGDSPGFLS 452

  Fly   450 QALENSNGQQANPK--------HELGQSAGEDSNS-SDTEPSDRG---------DGQHDGTL--- 493
            .|.|..:|..|:..        .::..|.|...:| .::...|:|         .|.|:|.:
Mouse   453 GAAEGEDGDAADVDGLAASTLLQQMMSSVGRAGDSDEESRTDDKGVMDYYLKYFSGAHEGDVYPA 517

  Fly   494 ---DGIDNQRSHSFPNAFLGLQGIPGLLPGPSGINSD--------------FVSRRSLEMRVRA- 540
               .|....|:.:|....:..:.|.|....|..|.:.              |..:..|::.:|.
Mouse   518 WSQKGEKKIRAKAFQKCPICEKVIQGAGKLPRHIRTHTGEKPYECNICKVRFTRQDKLKVHMRKH 582

  Fly   541 TDPRP--CPKCGKIYRSAHTLRTHLEDKHTVCPGYRCVLCGTVAKSRNSLHSHM---------SR 594
            |..:|  |.:||..:...:.|:.|:. .||....|:|..|.......:.||.|:         ||
Mouse   583 TGEKPYLCQQCGAAFAHNYDLKNHMR-VHTGLRPYQCDSCCKTFVRSDHLHRHLKKDGCNGVPSR 646

  Fly   595 QHRGISTKDLPVLPMPSAFDPELASRLLAKAGVKISP-----------AELRARASPTGG----- 643
            :.|....:.:|         |::.:...|..|:..:|           .|....|||.|.
Mouse   647 RGRKPRVRGVP---------PDVPAGAGAPPGLPDAPRNGQEKHFKDEEEDEEEASPDGSGRLNV 702

  Fly   644 SGSSGGGGGGGSSQA 658
            :||.|..|.||.:.|
Mouse   703 AGSGGDDGAGGPAVA 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	26/97 (27%)
		BTB	104..189	CDD:197585	25/86 (29%)
		zf-Di19	545..597	CDD:283297	16/62 (26%)
		C2H2 Zn finger	546..567	CDD:275371	5/20 (25%)
		C2H2 Zn finger	575..596	CDD:275371	7/29 (24%)
Zbtb7a	XP_006513342.3	BTB_POZ_ZBTB7A	165..284	CDD:349635	33/137 (24%)
		C2H2 Zn finger	534..554	CDD:275368	4/19 (21%)
		zf-H2C2_2	549..571	CDD:404364	2/21 (10%)
		C2H2 Zn finger	562..582	CDD:275368	3/19 (16%)
		zf-H2C2_2	575..599	CDD:404364	7/23 (30%)
		C2H2 Zn finger	590..610	CDD:275368	5/20 (25%)
		zf-H2C2_2	602..627	CDD:404364	7/25 (28%)
		C2H2 Zn finger	618..636	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000