DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ab and Btbd18

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	XP_002729248.1	Gene:	Btbd18 / 100363270	RGDID:	2323370	Length:	724	Species:	Rattus norvegicus

Alignment Length:	719	Identity:	144/719 - (20%)
Similarity:	220/719 - (30%)	Gaps:	281/719 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SPATP------PPSLNLSHQQQQHQQHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFT 115
            |||:|      |..|.::..|..|||         ||.:            |.|..|..:..:..
  Rat     3 SPASPKILYRNPRFLRVAFLQLHHQQ---------QSGV------------FCDALLQAEGEAVP 46

  Fly   116 AHKVVLSACSPYF-RRLLKANPCEHPIVILR--DVRCDDVENLLSFMYNGEVNVSHEQLPDFLKT 177
            ||..:||||||:| .||.:..|.:...|:|.  .::...:..|:.|:|..|:.||.|:..|.|..
  Rat    47 AHCCILSACSPFFTERLERERPVQGRKVVLELGGLKIQTLRKLVDFLYTSEMEVSQEEAQDVLSA 111

  Fly   178 AHLLQIRGL--ADVNGGY-----------------PYSKALSAAL-------------------- 203
            |..|::..|  ..:.||.                 |.:..:||.:
  Rat   112 ARQLRVSELETLQLEGGKLVKAPQGRRLNRECLQPPSAAPISARVVVPRSRPRTPLPVTQTPSPL 176

  Fly   204 -------------SHNSSN------------------------NNNNNSSSNNSLSNNNNNNNNN 231
                         :|..||                        .:::.||.......|.:|..:.
  Rat   177 GAVKLKSLGEEEGAHKKSNLPNADNLSDTLLLKKKARVCLTQERSSSPSSQREGPKENKSNPGST 241

  Fly   232 AESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNNSSSNNISGSLNSSLNSPFSAPQIP-- 294
            |..|.:..:...|.|.:...         |.:..|.|..:|..      :|.|:.|.|.|..|
  Rat   242 ALPSLYPSVDEQLLPRKIRL---------SRSKPSPHVYTSKP------SSMLSGPSSMPTAPGR 291

  Fly   295 -------------------------------PPVTASSAAAAAAAAASLTAAVAAAAAATAASAG 328
                                           ||....:......:..|              .|.
  Rat   292 RLWRQRTVSEATQGVDKQKPGEVSTLQSTPDPPDVGKTGGKKQPSPES--------------RAP 342

  Fly   329 SSSSAASGQ---------TSGT--PAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRK 382
            :|:|...||         .:||  ..:||       .|:||...:|....||   |..|..|:..
  Rat   343 ASNSVEEGQVGRVKLRKIVNGTCWEVVQE-------PPIRNTQDSPQILESS---DADEPPGTLL 397

  Fly   383 SHLT-------------PPPQKRIKSADLFRAQHGISPERLLLDREFPVAGQHPLTRNRSGRDTS 434
            |.:.             .|...|::.. |..|.|  ||:..::..||   |..|:.       |.
  Rat   398 SSVNEQEIPARIQLCHDSPENSRLQDI-LLSASH--SPDHPVVKSEF---GSSPML-------TG 449

  Fly   435 KDRERNLELRE------SLLGQALENSNGQ--QANPKHELGQSAGEDSNSSDTEPSDRGDGQHDG 491
            |:.|.|::.||      :||.|..|....:  .|....||.:........||.||.       .|
  Rat   450 KEPELNIDCREPYTFDTTLLSQPCEAEQYRITSAAATSELEEILDFMLCGSDVEPP-------VG 507

  Fly   492 TLD--GIDNQRSHSF-----------------PNAFLGLQGIPGLLPGPSGINSDFVSRRSLEMR 537
            :|:  |.:..|:.|:                 |:..|..:.:.||...|.|.|.:.|.
  Rat   508 SLESPGAEGCRTPSYHLSETGKNWIEGEEWCLPDMELWPRDLTGLEKEPVGENKEPVE------- 565

  Fly   538 VRATDPRPCPKCGKIYRSAHTLRTHLEDKHTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTK 602
                     |....:.||        |:..::.|....|:...|::...||        ||..|.
  Rat   566 ---------PFSPLVMRS--------ENTESIEPLSPLVMPSEVSREELSL--------RGSWTP 605

  Fly   603 DLPV 606
            ||.:
  Rat   606 DLEI 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	29/100 (29%)
		BTB	104..189	CDD:197585	28/89 (31%)
		zf-Di19	545..597	CDD:283297	9/51 (18%)
		C2H2 Zn finger	546..567	CDD:275371	4/20 (20%)
		C2H2 Zn finger	575..596	CDD:275371	4/20 (20%)
Btbd18	XP_002729248.1	BTB	24..123	CDD:279045	34/119 (29%)
Btbd18	XP_002729248.1	BTB	35..123	CDD:197585	28/87 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910