DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and Btbd18

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001138572.1	Gene:	Btbd18 / 100270744	MGIID:	3650217	Length:	723	Species:	Mus musculus

Alignment Length:	690	Identity:	145/690 - (21%)
Similarity:	227/690 - (32%)	Gaps:	224/690 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SPATP------PPSLNLSHQQQQHQQHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFT 115
            |||:.      |..|.::..|..|||         ||.:            |.|..|..:..:..
Mouse     3 SPASSKILYRNPRFLRVAFLQLHHQQ---------QSGV------------FCDALLQAEGEAVP 46

  Fly   116 AHKVVLSACSPYF-RRLLKANPCEHPIVILR--DVRCDDVENLLSFMYNGEVNVSHEQLPDFLKT 177
            ||..:||||||:| .||.:..|.:...|:|.  .::...:..|:.|:|..|:.||.|:..|.|..
Mouse    47 AHCCILSACSPFFTERLERERPVQGRKVVLEMGGLKIQTLRKLVDFLYTSEMEVSQEEAQDVLSA 111

  Fly   178 AHLLQIRGL--ADVNGGY-----------------PYSKALSAAL-------------------- 203
            |..|::..|  ..:.||.                 |.:..:||.:
Mouse   112 ARQLRVSELETLQLEGGKLVKAPQGRRLNRECLQPPAAAPISARVVGPKSRPQTPLPVTQTPSPL 176

  Fly   204 -------------SHNSSNNNNNNSSSNNSLSNNN----NNNNNNAESSNHNKISSYLSPNQTSA 251
                         :|..:|..|.:|.|:..|....    ...:.::.||...      .|.:|.:
Mouse   177 GAVRLKSLGEEEGAHKKTNLPNADSLSDTQLKKKARVCLTQESRSSPSSQRE------GPKETKS 235

  Fly   252 ACNNSSNSNSNNHSS------------SHNNSSSNNISGSLNSSLNSPFSAPQIP-----PPVTA 299
              |....:..:.:.|            |.:..|.:..:.:.:|.|:.|.|.|..|     ...|.
Mouse   236 --NPGPTALPSLYPSVDEQLLPRKIRLSRSKPSPHVYTSTPSSILSGPSSMPTAPGRRLWRQRTV 298

  Fly   300 SSAAAAA-----AAAASLTAAVAAAAAATAAS---------AGSSSSAASGQ---------TSGT 341
            |..|...     .....|.:....:.....|.         |.:|||...||         .:||
Mouse   299 SKEAQGVDKQKPGEVRPLQSTPDPSDVGKPAENKKQSPELRAPTSSSVEEGQVGRVKLRKIVNGT 363

  Fly   342 --PAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLT-------------PPPQK 391
              ..:||       .|:||...:|.....|   |:.|..|:..|.:.             .|...
Mouse   364 CWEVVQE-------PPLRNTQDSPQILEPS---DVEEPSGTLLSSVNEQEIPARIQLCQDSPESP 418

  Fly   392 RIKSADLFRAQHGISPERLLLDREFPVAGQHPLTRNRSGRDTSKDRERNLELRE------SLLGQ 450
            |::.. |..|.|  ||:..::..||   |..|:.       |.|:.:.|::.||      :||||
Mouse   419 RLQDI-LLSASH--SPDHPMVKSEF---GSSPML-------TGKESDLNIDCREPYTFDTTLLGQ 470

  Fly   451 ALENSNGQ--QANPKHELGQSAGEDSNSSDTEPSDRGDGQHDGTLD--GIDNQRSHSFPNAFLGL 511
            ..|....:  .|....||.:........||.||.       .|:|:  |.:..|:.|:..:..|.
Mouse   471 PCEAEQYRITSAAATSELEEIFDFMLCGSDVEPP-------VGSLESPGAEGCRTPSYHLSETGK 528

  Fly   512 QGIPG---LLPGP-------SGINSDFVSRRSLEMRVRATDPRPCPKCGKIYRSAHTLRTHLEDK 566
            ..|.|   .||..       :|:..:.||.....:.         |....:.||.:|     |..
Mouse   529 NWIEGEEWCLPDMELWPRDLTGLEKEPVSENKEPVE---------PFSPLVMRSENT-----ESF 579

  Fly   567 HTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPV 606
            ..:.|   .|:...|::...||        ||..|.||.:
Mouse   580 EPLSP---LVMPSEVSREELSL--------RGSWTPDLEI 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	29/100 (29%)
		BTB	104..189	CDD:197585	28/89 (31%)
		zf-Di19	545..597	CDD:283297	10/51 (20%)
		C2H2 Zn finger	546..567	CDD:275371	5/20 (25%)
		C2H2 Zn finger	575..596	CDD:275371	4/20 (20%)
Btbd18	NP_001138572.1	BTB_POZ_BTBD18	20..138	CDD:349602	37/138 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..176		2/25 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..350		29/169 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..394		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..637		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910