Protein Alignment Ca-beta and cacnb2a

DIOPT Version :9

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0259822
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001077037.1
• Gene: cacnb2a / 795492
• ZFINID: ZDB-GENE-080808-7
• Length: 598
• Species: Danio rerio
• Alignment Length: 619
• Identity: 294/619 - (47%)
• Similarity: 356/619 - (57%)
• Gaps: 135/619 - (21%)

  Fly    41 GSADSNYSQPS-SDLSLDEEKESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQ 104
            |||||..|:|| ||:||:|:||:||||.||||.:|||||:||||||||||||.|..:.:||.||.
Zfish    23 GSADSYTSRPSDSDVSLEEDKETLRREAERQAQAQLDKAKSKPVAFAVRTNVGYSASSEDDVPVP 87

  Fly   105 GGAVSFEIREFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDN--IRMQNQTRPSRLYGTK-- 165
            |..:||:.::|||:|||::|:||||||||||||:||||||.||::  :|.:.:.:..|.|.:|
Zfish    88 GTGISFDPKDFLHVKEKFNNDWWIGRLVKEGCDIGFIPSPVKLESSRLRQEQRAKQGRFYSSKSG 152

  Fly   166 GSSSGNLGAGGQAGAEPSRGSTPPTPGDESDSMGPGRHGKTPAAAANKEKRKPFFKKQETASPYD 230
            .:||.:||    .....||.||||:                        ..|.:.|..|.|.|||
Zfish   153 ANSSSSLG----DIVSNSRKSTPPS------------------------SAKQWQKSTEHAPPYD 189

  Fly   231 VVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKRAI 295
            ||||||||||||||||||||||||||||||||||||||||.||||.|||||||||::|||||.||
Zfish   190 VVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRITITRVAADISLAKRSVLNNPSKHAI 254

  Fly   296 MERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKVLQ 360
            :|||::||: |.:||.||||||||||:|||||||.|||||||||.||.|||.|||:||:|.||||
Zfish   255 IERSNTRSN-LAEVQSEIERIFELARTLQLVVLDADTINHPSQLGKTCLAPIIVYIKITSPKVLQ 318

  Fly   361 RLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEYLETYWKATHPDIRA 425
            ||||||||||||:|:||||||:||||||.::||:|||||||||||||:|:|||.|||:|||
Zfish   319 RLIKSRGKSQAKHLNVQMVAADKLAQCPSELFDIILDENQLEDACEHMADYLELYWKSTHP---- 379

  Fly   426 VPPIARPLPQEASPSADPARLGPTPPVD------------GEEFVDEQ------DPRMGMSGGDR 472
                         ||..|:    ||.:|            .|:..:.|      |.....:..||
Zfish   380 -------------PSGAPS----TPLLDKLSAVTAAAVACKEQLTNTQPKGTGSDQHADRAAADR 427

  Fly   473 ---------------------------EGSRERDRDSRERERERERERDYWDREFNRDRSSKDRE 510
                                       |...|.|.|..|...||...||..|...|:..||...|
Zfish   428 TSFYEDYHHHHHPQQQHYQTQKQESFEEEEEEEDDDEEENTDERHDNRDQQDHHKNQHSSSTRTE 492

  Fly   511 RDLEWERERAREWER-------------------ERERDWDREFDWDQGGTSYQHSRRQPTSVRH 556
            |.............|                   |.:.....:.:.:|......|.|......||
Zfish   493 RHHHHRHHHHHHHHRHHHSRTGRTLSKQETLESTETQTHSQPQQEEEQESVQPNHHRHHHHHHRH 557

  Fly   557 QERGGGVGAGGGGGGVGGGYERDRERERYERRER 590
            ..|.                |:::|.:..||..|
Zfish   558 HHRN----------------EKEKEHDHNERNSR 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:288872	28/40 (70%)
		SH3_CACNB	85..146	CDD:212797	40/60 (67%)
		Guanylate_kin	234..415	CDD:279019	150/180 (83%)
		NK	244..416	CDD:302627	140/171 (82%)
cacnb2a	NP_001077037.1	SH3_CACNB2	63..131	CDD:212973	46/67 (69%)
		Guanylate_kin	193..373	CDD:279019	150/180 (83%)
		NK	203..374	CDD:302627	140/171 (82%)
		VGCC_beta4Aa_N	23..64	CDD:288872	28/40 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579981
Domainoid	1	1.000	298	1.000	Domainoid score	I1418
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1258
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24806
orthoMCL	1	0.900	-	-		OOG6_105007
Panther	1	1.100	-	-	LDO	PTHR11824
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1029
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.890