Protein Alignment Ca-beta and CACNB4

DIOPT Version :9

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0259822
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_000717.2
• Gene: CACNB4 / 785
• HGNCID: 1404
• Length: 520
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 287/549 - (52%)
• Similarity: 358/549 - (65%)
• Gaps: 85/549 - (15%)

  Fly    37 LFTQGSADSNYSQPS-SDLSLDEEKESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDD 100
            :..||||||..|:|| ||:||:|::|::|:|:|:||..||::|:||||||||:|||:|.||:|:|
Human    46 ILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDED 110

  Fly   101 SPVQGGAVSFEIREFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDNIRMQNQTRPSRLYGTK 165
            .||...|:||:.::||||||||:|:|||||||||||::||||||.:|:|||:|.:.:..|.:|
Human   111 VPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHG-- 173

  Fly   166 GSSSGNLGAGGQAGAEPSRGSTPPTPGDESDSMG---PGRHGKTPAAAANKEKRKPFFKKQETAS 227
            |.||||                      .|.|:|   .|....||.:.| |:|:    |..|...
Human   174 GKSSGN----------------------SSSSLGEMVSGTFRATPTSTA-KQKQ----KVTEHIP 211

  Fly   228 PYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSK 292
            |||||||||||||||||||||||||||||||||||||||:|||.||||.|||||||||::|||||
Human   212 PYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSK 276

  Fly   293 RAIMERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSK 357
            |||:|||::||. |.:||.||||||||||||||||||.||||||:||.||||||.||::|:||.|
Human   277 RAIIERSNTRSS-LAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPK 340

  Fly   358 VLQRLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEYLETYWKATH-- 420
            |||||||||||||:|:|:||:|||:|||||||:|||||||||||||||||:.||||.||:|||
Human   341 VLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTT 405

  Fly   421 PDIRAVPPIARPLPQEASPSADPARLGPTPPVDGEEFVDEQDPRMGMSGGDREGSRERDRDSRER 485
            ......|.:.|.|...|        |.|.|              ..:||...:..|..:..:...
Human   406 SSTPMTPLLGRNLGSTA--------LSPYP--------------TAISGLQSQRMRHSNHSTENS 448

  Fly   486 ERERERERDYWDREFNRDRSSKDRERDLEWERERAREWERERERDWDREFDWDQGGTSYQHSRRQ 550
            ..|| |.....|..::.:|:.|.|.| |....:.:|:.....|.|:.         .|||.:.:.
Human   449 PIER-RSLMTSDENYHNERARKSRNR-LSSSSQHSRDHYPLVEEDYP---------DSYQDTYKP 502

  Fly   551 PTSVRHQERGGGVGAGGGGGGVGGGYERD 579
                 |:.||.           .|||..|
Human   503 -----HRNRGS-----------PGGYSHD 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:288872	22/40 (55%)
		SH3_CACNB	85..146	CDD:212797	42/60 (70%)
		Guanylate_kin	234..415	CDD:279019	151/180 (84%)
		NK	244..416	CDD:302627	141/171 (82%)
CACNB4	NP_000717.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		14/24 (58%)
		VGCC_beta4Aa_N	50..91	CDD:371868	22/40 (55%)
		SH3_CACNB4	91..158	CDD:212976	46/66 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..185		9/42 (21%)
		Guanylate_kin	218..398	CDD:366206	151/180 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..520		27/132 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1433
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20188
Inparanoid	1	1.050	537	1.000	Inparanoid score	I1199
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000994
OrthoInspector	1	1.000	-	-		otm40473
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11824
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1029
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.060