DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-beta and CACNB3

DIOPT Version :9

Sequence 1:	NP_001260375.1	Gene:	Ca-beta / 34557	FlyBaseID:	FBgn0259822	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_000716.2	Gene:	CACNB3 / 784	HGNCID:	1403	Length:	484	Species:	Homo sapiens

Alignment Length:	535	Identity:	276/535 - (51%)
Similarity:	338/535 - (63%)	Gaps:	94/535 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SYQSGYNKLFTQGSADSNYSQPS--SDLSLDEEKESLRREKERQALSQLDKARSKPVAFAVRTNV 91
            ||..|:.. ...|||||..|:||  ||:||:|::||.|||.|.||..||::|:.|||||||||||
Human     5 SYVPGFED-SEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNV 68

  Fly    92 AYDGAIDDDSPVQGGAVSFEIREFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDNIRMQNQT 156
            :|.|.:|::.||||..|:||.::||||||||.|:||||||||||.|:.|||||.:|::||::.:.
Human    69 SYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQ 133

  Fly   157 RPSRLYGTKGSSSGNLGAGGQAGAEPSRGSTPPTPGDESDSMGPGRHGKTPAAAANKEKRKPFFK 221
            :..|        |||                   |...|| :| .|....|:.|..|:      |
Human   134 KARR--------SGN-------------------PSSLSD-IG-NRRSPPPSLAKQKQ------K 163

  Fly   222 KQETASPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSI 286
            :.|...|||||||||||||||||||||||||||||||||||||||:|||.||||.||:||||||:
Human   164 QAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSV 228

  Fly   287 MNNPSKRAIMERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYL 351
            :|||.||.|:||||:||. :.:||.|||||||||:||||||||.||||||:|||||||||.||::
Human   229 LNNPGKRTIIERSSARSS-IAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFV 292

  Fly   352 KISSSKVLQRLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEYLETYW 416
            |:||.|||||||:||||||.|:|:|||:|.:||.||||:.||||||||||||||||:|||||.||
Human   293 KVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYW 357

  Fly   417 KATHPDIRAVPPIARPLPQEASPSADPARLGPTPPVDG-------EEFVDEQDP--RMGMSGGDR 472
            :|||                 .|:..|..|||...:.|       .|..:|..|  |..:...|.
Human   358 RATH-----------------HPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDE 405

  Fly   473 --EGSRERDRDSRERERERERERDYWD---------REFN-----------RDR----SSKDRER 511
              |.||:....|.:|. .|..|.||.|         |:..           :||    .|:....
Human   406 ASESSRQAWTGSSQRS-SRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHS 469

  Fly   512 DLEWERERAREWERE 526
            |..|:|.  |.|.::
Human   470 DRNWQRN--RPWPKD 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:288872	24/41 (59%)
		SH3_CACNB	85..146	CDD:212797	42/60 (70%)
		Guanylate_kin	234..415	CDD:279019	145/180 (81%)
		NK	244..416	CDD:302627	135/171 (79%)
CACNB3	NP_000716.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		24/47 (51%)
		VGCC_beta4Aa_N	16..58	CDD:314861	24/41 (59%)
		SH3_CACNB3	58..125	CDD:212975	46/66 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..170		14/75 (19%)
		Guanylate_kin	176..356	CDD:331880	145/180 (81%)
		Mediates interaction with the alpha subunit. /evidence=ECO:0000250\|UniProtKB:P54287	195..345		116/150 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..484		24/99 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1433
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000994
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11824
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.010