Protein Alignment Ca-beta and CACNB2

DIOPT Version :10

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0287724
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_963890.2
• Gene: CACNB2 / 783
• HGNCID: 1402
• Length: 660
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 324/631 - (51%)
• Similarity: 403/631 - (63%)
• Gaps: 118/631 - (18%)

  Fly     5 ASSSDAPSVQGGQHRESRF--GLGYPSYQSGYNKLFTQGSADSNYSQPS-SDLSLDEEKESLRRE 66
            |..:.|.|...|..|::||  ..|..|..:..|....||||||..|:|| ||:||:|::|::|||
Human    34 ALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRRE 98

  Fly    67 KERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQGGAVSFEIREFLHIKEKYDNNWWIGRL 131
            .||||.:||:||::|||||||||||:|..|.:||.||.|.|:|||.::|||:|||::|:||||||
Human    99 AERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRL 163

  Fly   132 VKEGCDVGFIPSPAKLDNIRMQNQTR--PSRLYGTK--GSSSGNLGAGGQAGAEP-SRGSTPPTP 191
            |||||::||||||.||:|:|:|::.|  ..:.|.:|  |:||.:||     ...| ||.||||:.
Human   164 VKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLG-----DIVPSSRKSTPPSS 223

  Fly   192 GDESDSMG--------PGRHGKTPAAAAN-------KEKRKPFFKKQETASPYDVVPSMRPVVLV 241
            ..:.|:.|        |..| ::|..:||       ||||.|||||.|...||||||||||||||
Human   224 AIDIDATGLDAEENDIPANH-RSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLV 287

  Fly   242 GPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKRAIMERSSSRSDCL 306
            |||||||||||||||||||||||||||||.||||.|||||||||::|||||.||:|||::||. |
Human   288 GPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSS-L 351

  Fly   307 GKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKVLQRLIKSRGKSQA 371
            .:||.||||||||||:|||||||.||||||:||:||||||.|||:||||.|||||||||||||||
Human   352 AEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQA 416

  Fly   372 KNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEYLETYWKATHPDIRAVP--------- 427
            |:|:||||||:|||||||::||||||||||||||||:|:|||.|||||||...::|
Human   417 KHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLA 481

  Fly   428 ---------------------------PIARPLPQEASPSADPA----------------RLGPT 449
                                       ||......|..||.:|.                |.|.:
Human   482 TSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSSAPHHNHRSGTS 546

  Fly   450 PPVDGEEFVDEQ----------DPRMGMS---------------GGDREGSRE-RDRDSRERERE 488
            ..:..:|..|.:          :|:...|               ..:..||.: |.|:||.|.|:
Human   547 RGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETHGSSDHRHRESRHRSRD 611

  Fly   489 RERERDYWDREFNRDRS---SKDR--ERD---LEWERERAREWERE 526
            .:||:|:  .|.|:.||   ||||  |:|   :..:|..|.||.|:
Human   612 VDREQDH--NECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRD 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:463445	25/40 (63%)
		SH3_CACNB	85..146	CDD:212797	42/60 (70%)
		Guanylate_kin	234..415	CDD:395500	153/180 (85%)
CACNB2	NP_963890.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..101		27/61 (44%)
		VGCC_beta4Aa_N	72..113	CDD:463445	25/40 (63%)
		SH3_CACNB2	112..180	CDD:212973	47/67 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..261		22/76 (29%)
		Guanylate_kin	280..460	CDD:395500	153/180 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	486..641		33/156 (21%)