Protein Alignment Ca-beta and cacnb4a

DIOPT Version :9

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0259822
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001106991.1
• Gene: cacnb4a / 562422
• ZFINID: ZDB-GENE-080320-2
• Length: 519
• Species: Danio rerio
• Alignment Length: 592
• Identity: 294/592 - (49%)
• Similarity: 371/592 - (62%)
• Gaps: 109/592 - (18%)

  Fly    17 QHRESRFGLG----YPSYQ---SGYNK----------------LFTQGSADSNYSQPS-SDLSLD 57
            :|..:|.|:|    .|.:|   ..|::                :..||||||..|:|| ||:|||
Zfish     3 RHIYTRHGIGDGVQKPIFQVNRGTYSRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLD 67

  Fly    58 EEKESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQGGAVSFEIREFLHIKEKY 122
            ||:.. |:|||:||..||::|::|.|||||||||:|.||:|:|.||.|.|:||:.::||||||||
Zfish    68 EEQGG-RQEKEQQATVQLERAKAKAVAFAVRTNVSYCGALDEDVPVAGTAISFDAKDFLHIKEKY 131

  Fly   123 DNNWWIGRLVKEGCDVGFIPSPAKLDNIRMQNQTRPSRLYG-TKGSSSGNLGAGGQAGAEPSRGS 186
            :|:||||||||||||:||||||.||:|||:|...:..|.:| :.|:||.:||       |...|:
Zfish   132 NNDWWIGRLVKEGCDIGFIPSPLKLENIRLQQDQKRGRFHGKSSGNSSSSLG-------EMVSGT 189

  Fly   187 TPPTPGDESDSMGPGRHGKTPAAAANKEKRKPFFKKQETASPYDVVPSMRPVVLVGPSLKGYEVT 251
            ..|.|                 |:|.|:|:    |..|...||||||||||||||||||||||||
Zfish   190 FKPNP-----------------ASAGKQKQ----KVAEHIPPYDVVPSMRPVVLVGPSLKGYEVT 233

  Fly   252 DMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKRAIMERSSSRSDCLGKVQEEIERI 316
            |||||||||||||||||||.||||.|||||||||::||||||||:|||::||: |.:||.|||||
Zfish   234 DMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSN-LAEVQSEIERI 297

  Fly   317 FELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKVLQRLIKSRGKSQAKNLSVQMVAA 381
            |||||||||||||.||||||:||.||||||.||::|:||.||||||||||||||:|:|:||:|||
Zfish   298 FELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAA 362

  Fly   382 EKLAQCPPDMFDVILDENQLEDACEHIAEYLETYWKATHPDIRAV--PPIARPLPQEASPSADPA 444
            :|||||||:|||:|||||||||||||::||||.||:|||..:...  |.:.|.|...|
Zfish   363 DKLAQCPPEMFDIILDENQLEDACEHLSEYLEAYWRATHTSLSTPLNPLLGRNLGSTA------- 420

  Fly   445 RLGPTP-PVDGEEFVDEQDPRMGMSGGDREGSRERDRDSRERERERERERDYWDREFNRDRSSKD 508
             |.|.| .:.|.:           |..::..:...|....||......:.:|    .|.:|..|.
Zfish   421 -LSPYPTAISGLQ-----------SQRNKNSNHITDNSPMERRSLMTSDENY----HNNERQKKT 469

  Fly   509 RERDLEWERERAREWERERERDWDREFDWDQGGTSYQHSRRQPTSVR-HQERGGGVGAGGGGGGV 572
            ..| |....:::|:.....|.|:...:               |.:.: |:.||.
Zfish   470 HNR-LSSSSQQSRDHYPLVEEDYHDPY---------------PDAYKPHRNRGS----------- 507

  Fly   573 GGGYERD 579
            .|||..|
Zfish   508 PGGYSND 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:288872	24/40 (60%)
		SH3_CACNB	85..146	CDD:212797	45/60 (75%)
		Guanylate_kin	234..415	CDD:279019	151/180 (84%)
		NK	244..416	CDD:302627	141/171 (82%)
cacnb4a	NP_001106991.1	VGCC_beta4Aa_N	50..86	CDD:288872	23/36 (64%)
		SH3	97..157	CDD:302595	43/59 (73%)
		Guanylate_kin	216..396	CDD:279019	151/180 (84%)
		NK	226..397	CDD:302627	141/171 (82%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	298	1.000	Domainoid score	I1418
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20188
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000994
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11824
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1029
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.010