Protein Alignment Ca-beta and Cacnb1

DIOPT Version :9

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0259822
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_006247471.1
• Gene: Cacnb1 / 50688
• RGDID: 68382
• Length: 642
• Species: Rattus norvegicus
• Alignment Length: 658
• Identity: 322/658 - (48%)
• Similarity: 401/658 - (60%)
• Gaps: 105/658 - (15%)

  Fly     1 MVQRASSSDA--------------PSVQGG-QHRESRF--GLGYPSYQSGYNKLFTQGSADSNYS 48
            |||::..|..              ||.||. ..|:.||  ..|..|..:..|....||||:|..|
  Rat     1 MVQKSGMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTS 65

  Fly    49 QPS-SDLSLDEEKESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQGGAVSFEI 112
            :|| ||:||:|::|:||:|.|||||:||:||::|||||||||||.|:.:..|:.||||.|::||.
  Rat    66 RPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEP 130

  Fly   113 REFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDNIR-MQNQT-RPSRLYGTK-----GSSSG 170
            ::||||||||:|:|||||||||||:|||||||.|||::| :|.|| |.:||..:|     .||.|
  Rat   131 KDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQTLRQNRLSSSKSGDNSSSSLG 195

  Fly   171 NLGAGGQAGAEPSRGSTPPTPGDESDS----MGP----------GRHG---KTPAAAANKE---- 214
            ::..|       :|..|||..|:|..:    :.|          |.||   ||..::....
  Rat   196 DVVTG-------TRRPTPPASGNEMTNFAFELDPLELEEEEAELGEHGGSAKTSVSSVTTPPPHG 253

  Fly   215 KRKPFFKKQETASPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADI 279
            ||.|||||.|...||||||||||::|||||||||||||||||||||||||||:|||.||||.|||
  Rat   254 KRIPFFKKTEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADI 318

  Fly   280 SLAKRSIMNNPSKRAIMERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSL 344
            ||||||::|||||..|:|||::||. |.:||.||||||||||:||||.||.||||||:||:||||
  Rat   319 SLAKRSVLNNPSKHIIIERSNTRSS-LAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSL 382

  Fly   345 APTIVYLKISSSKVLQRLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIA 409
            ||.|||:||:|.||||||||||||||:|:|:||:.|:||||||||:|||:|||||||||||||:|
  Rat   383 APIIVYIKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLA 447

  Fly   410 EYLETYWKATHPDIRAVP-PIARPLPQEASPSADPARL----GP-----TPPVD---GEE-FVDE 460
            ||||.|||||||.....| |:.......|:.:|.||.:    ||     ..|:|   ||. .|.|
  Rat   448 EYLEAYWKATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLDRATGEHASVHE 512

  Fly   461 QDPRMGMSGGDREGSRERDRDSRERERERERERDYWDREFNRDRSSKDRER-----DLEWERER- 519
            ....:|...|....:....|....|...|:   |.:|.:....|:|...|.     |:|.:...
  Rat   513 YPGELGQPPGLYPSNHPPGRAGTLRALSRQ---DTFDADTPGSRNSAYTEPGDSCVDMETDPSEG 574

  Fly   520 -------------AREWERERERDWDREFDWDQGGTSYQHSRRQPTSVRHQERGGGVGAG----- 566
                         ||:...|.|.|::.|..        .:..|.....|:...|||...|
  Rat   575 PGPGDPAGGGTPPARQGSWEEEEDYEEEMT--------DNRNRGRNKARYCAEGGGPVLGRNKNE 631

  Fly   567 --GGGGGV 572
              |.|.||
  Rat   632 LEGWGQGV 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:288872	25/40 (63%)
		SH3_CACNB	85..146	CDD:212797	43/60 (72%)
		Guanylate_kin	234..415	CDD:279019	145/180 (81%)
		NK	244..416	CDD:302627	137/171 (80%)
Cacnb1	XP_006247471.1	VGCC_beta4Aa_N	58..99	CDD:403316	25/40 (63%)
		SH3	99..166	CDD:418401	48/66 (73%)
		Guanylate_kin	273..453	CDD:395500	145/180 (81%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340131
Domainoid	1	1.000	296	1.000	Domainoid score	I1418
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	528	1.000	Inparanoid score	I1187
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000994
OrthoInspector	1	1.000	-	-		otm44615
orthoMCL	1	0.900	-	-		OOG6_105007
Panther	1	1.100	-	-	O	PTHR11824
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1029
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.890