Protein Alignment Ca-beta and Cacnb3

DIOPT Version :10

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0287724
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_017450162.1
• Gene: Cacnb3 / 25297
• RGDID: 2248
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 529
• Identity: 273/529 - (51%)
• Similarity: 337/529 - (63%)
• Gaps: 95/529 - (17%)

  Fly    40 QGSADSNYSQPS--SDLSLDEEKESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSP 102
            :|||||..|:||  ||:||:|::||.|||.|.||..||::|:.|||||||||||:|.|.:|::.|
  Rat    26 EGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECP 90

  Fly   103 VQGGAVSFEIREFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDNIRMQNQTRPSRLYGTKGS 167
            |||..|:||.::||||||||.|:||||||||||.|:.|||||.:|::||::.:.:..|
  Rat    91 VQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARR------- 148

  Fly   168 SSGNLGAGGQAGAEPSRGSTPPTPGDESDSMGPGRHGKTPAAAANKEKRKPFFKKQETASPYDVV 232
             |||                   |...|| :| .|....|:.|..|:      |:.|...|||||
  Rat   149 -SGN-------------------PSSLSD-IG-NRRSPPPSLAKQKQ------KQAEHVPPYDVV 185

  Fly   233 PSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKRAIME 297
            ||||||||||||||||||||||||||||||||||:|||.||||.||:||||||::|||.||.|:|
  Rat   186 PSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIE 250

  Fly   298 RSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKVLQRL 362
            |||:||. :.:||.|||||||||:||||||||.||||||:|||||||||.||::|:||.||||||
  Rat   251 RSSARSS-IAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRL 314

  Fly   363 IKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEYLETYWKATHPDIRAVP 427
            |:||||||.|:|:|||:|.:||.||||:.||||||||||:|||||:|||||.||:|||
  Rat   315 IRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLDDACEHLAEYLEVYWRATH------- 372

  Fly   428 PIARPLPQEASPSADPARLGPTPPVDG-------EEFVDEQDP--RMGMSGGDR--EGSRERDRD 481
                      .|:..|..|||...:.|       .|..:|..|  |..:...|.  |.||:....
  Rat   373 ----------HPAPGPGMLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTG 427

  Fly   482 SRERERERERERDYWDR-----EFNRDRSS----------------KDRERDLEWERERAREWER 525
            |.:|. .|..|.||.|.     :.:|..:|                :|.|.|     ...|.|
  Rat   428 SSQRS-SRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHD-----HNDRNW-- 484

  Fly   526 ERERDWDRE 534
            :|.|.|.::
  Rat   485 QRNRPWPKD 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:463445	24/41 (59%)
		SH3_CACNB	85..146	CDD:212797	42/60 (70%)
		Guanylate_kin	234..415	CDD:395500	144/180 (80%)
Cacnb3	XP_017450162.1	VGCC_beta4Aa_N	27..69	CDD:463445	24/41 (59%)
		SH3_CACNB3	69..136	CDD:212975	46/66 (70%)
		Guanylate_kin	187..367	CDD:395500	144/180 (80%)