DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-beta and cacnb1

DIOPT Version :9

Sequence 1:	NP_001260375.1	Gene:	Ca-beta / 34557	FlyBaseID:	FBgn0259822	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001121430.1	Gene:	cacnb1 / 100158521	XenbaseID:	XB-GENE-995022	Length:	583	Species:	Xenopus tropicalis

Alignment Length:	563	Identity:	302/563 - (53%)
Similarity:	373/563 - (66%)	Gaps:	61/563 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RESRF--GLGYPSYQSGYNKLFTQGSADSNYSQPS-SDLSLDEEKESLRREKERQALSQLDKARS 80
            |:|||  ..|..|..:..|....||||:|..|:|| ||:||:|::|:||:|.||.||:||:||::
Frog    35 RKSRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERHALAQLEKAKT 99

  Fly    81 KPVAFAVRTNVAYDGAIDDDSPVQGGAVSFEIREFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPA 145
            |||||||||||.|..:..||:||||..::|:.::||||||||:|:|||||.|:|||:|||||||.
Frog   100 KPVAFAVRTNVGYSPSPGDDAPVQGMCINFDPKDFLHIKEKYNNDWWIGRAVREGCEVGFIPSPV 164

  Fly   146 KLDNIRM--QNQTRPSRLYGTKGSSSGNLGAGGQAGAEPSRGSTPPTPGDESDSMGPGRHGKTPA 208
            ||:::|:  :.:.|.|||     |||.::|.....|...| |:..|||               ||
Frog   165 KLEHMRLLQEQKMRQSRL-----SSSKSIGNSNSLGDVVS-GTRRPTP---------------PA 208

  Fly   209 AAANKEKRKPFFKKQETASPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIIT 273
            .|..::      |..|...||||||||||::|||||||||||||||||||||||||||:|||.||
Frog   209 TAKQRQ------KSTEHIPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISIT 267

  Fly   274 RVMADISLAKRSIMNNPSKRAIMERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQ 338
            ||.|||||||||::|||||..|||||::||. |.:||.||||||||||:||||.||.||||||:|
Frog   268 RVTADISLAKRSVLNNPSKHNIMERSNTRSS-LAEVQSEIERIFELARTLQLVALDADTINHPAQ 331

  Fly   339 LAKTSLAPTIVYLKISSSKVLQRLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLED 403
            ||||||||.|||:||:|.|||.||||||||||||:|:||||||:|||||||:|||:|||||||||
Frog   332 LAKTSLAPIIVYIKITSPKVLHRLIKSRGKSQAKHLNVQMVAADKLAQCPPEMFDIILDENQLED 396

  Fly   404 ACEHIAEYLETYWKATHPDIRAVPPIARPLP---------QEASPSADPARLGPTPPVDGEEFVD 459
            ||||:|||||.|||||||     |.|..|.|         ..||..|..:.|..:..|.||...|
Frog   397 ACEHLAEYLEAYWKATHP-----PSINPPNPLLNRTLATAALASSPAPVSNLQGSYLVHGELRPD 456

  Fly   460 EQDPRMGMSGGD----REGSRERDR-DSRERERERERERDYWDREFNRDRSSKDRERDLEWERER 519
            ..| :|||..|.    :.|||...| |:.|.|.:..|:..|.:    ...|..|.|.| .:|...
Frog   457 GAD-QMGMYEGQLRRGQMGSRILSRHDTLESETQGSRDSAYTE----PGDSCMDIETD-PYEDPE 515

  Fly   520 AREWERERERDWDREFDWDQGGTSYQH--SRRQPTSVRHQERG 560
            .:....|..| ..|:..|::.|...::  .||:..|.|.|.:|
Frog   516 PKSQGGETRR-LQRQGSWEELGPDQENLLQRRRRESPRPQGKG 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:288872	24/40 (60%)
		SH3_CACNB	85..146	CDD:212797	40/60 (67%)
		Guanylate_kin	234..415	CDD:279019	149/180 (83%)
		NK	244..416	CDD:302627	141/171 (82%)
cacnb1	NP_001121430.1	VGCC_beta4Aa_N	59..100	CDD:371868	24/40 (60%)
		SH3_CACNB1	100..167	CDD:212974	45/66 (68%)
		Guanylate_kin	228..408	CDD:366206	149/180 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1406
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	535	1.000	Inparanoid score	I1175
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000994
OrthoInspector	1	1.000	-	-		otm47649
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1029
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050