DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and GLR5

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_565744.1	Gene:	GLR5 / 817801	AraportID:	AT2G32400	Length:	921	Species:	Arabidopsis thaliana

Alignment Length:	520	Identity:	104/520 - (20%)
Similarity:	197/520 - (37%)	Gaps:	134/520 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PCASAAAFSCILVLLLLGCQRSNPLAAGATVSSMRRLTDTINIGFLAEYSQM--RVTLGGLPLAI 66
            |..:..|...:::::.:.|||                ...:|||.:..:..:  |.....|..|:
plant     7 PSVAITALIVVILVVPMDCQR----------------PQLVNIGAVFAFDSVIGRAAKVALEAAV 55

  Fly    67 EDVNKNPNLLPGKKLAFKPVDIGHKMSAYRV-KPLRAMTQMREAGVTAFIGPDESCTTEAL--LA 128
            .|||.:.:.|...:|.....|     ||..| :......::.|..|.|.|||..|.....:  :|
plant    56 SDVNNDKSFLKETELRLLMED-----SACNVFRGSFGAFELLEKEVVAMIGPISSSVAHTISDIA 115

  Fly   129 SAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWGSD 193
            ...:.|::||..:||.:| ...|..|.||....:....:::.|:|.:.|.:...|.|...:..:.
plant   116 KGLHFPLVSFAATDPTLS-ALQFPFFLRTTPNDAHQMSALVDLINFYGWKEVISVYSDDELGRNG 179

  Fly   194 VARAIQELAEAR---NFTI-----SHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEHIA 250
            |:....||.:.|   ::.:     |..|::::.:..:|::.            .|:|:.   |..
plant   180 VSALDDELYKKRSRISYKVPLSVHSDEKFLTNALNKSKSIG------------PRVYIL---HFG 229

  Fly   251 MVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKE-KSKSLDKISFRSVI 314
            ....:|                     |:|..:::.:|...|:  ::..: .|.:||.:|.:..:
plant   230 PDPLLR---------------------IFDIAQKLQMMTHEYV--WLATDWLSVTLDSLSDKGTL 271

  Fly   315 K-------ISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVR 372
            |       :....|::..:.....|::                 .|.|:..|.||.||:|.:...
plant   272 KRLEGVVGLRQHIPESVKMEHFTHKLQ-----------------SNRSMNAYALHAYDTVWMIAH 319

  Fly   373 AITEVLRLGGDI---YDGNLVMSHIFNRSYHSIQGFDVYIDSNGD------AEGNYTVITLQNDV 428
            .|.|:|..|.:|   |...|:.:.........|:.|     ::|:      .:.|:|.|..|...
plant   320 GIEELLNEGINITFSYSEKLLHARGTKLHLEKIKFF-----NSGELLLEKLLKVNFTGIAGQVQF 379

  Fly   429 GSGAS-IG------SLAKMSMQPVGFFAYDKNS----VIPEFR-------YIKNDR--PIQWLNG 473
            |||.: ||      ::.|..:..|||  :.||.    |.|:.|       ::.:::  .|.|..|
plant   380 GSGRNVIGCDYEIINVNKTDVHTVGF--WSKNGGFSVVAPKTRHSQKKTSFVSDEKLGDITWPGG 442

Fly 474 473
plant 443 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	90/440 (20%)
		ANF_receptor	59..427	CDD:279440	78/395 (20%)
		PHA02988	534..826	CDD:165291
		PK_GC-A_B	550..832	CDD:270944
		HNOBA	<847..886	CDD:285003
		CYCc	865..1057	CDD:214485
		Guanylate_cyc	892..1076	CDD:278633
GLR5	NP_565744.1	PBP1_GABAb_receptor	32..416	CDD:107361	93/451 (21%)
		ANF_receptor	46..396	CDD:279440	83/415 (20%)
		GluR_Plant	458..800	CDD:270404
		Lig_chan	581..832	CDD:278489
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000