DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and si:dkey-37g12.1

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	XP_021333677.1	Gene:	si:dkey-37g12.1 / 796669	ZFINID:	ZDB-GENE-090312-145	Length:	882	Species:	Danio rerio

Alignment Length:	911	Identity:	331/911 - (36%)
Similarity:	497/911 - (54%)	Gaps:	91/911 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 VARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGL 258
            ||:..|  ||..|.|::.::.|...:....| |...:::.|.....||.| |..|..:|..:...
Zfish    30 VAQTYQ--AEHNNITVAKYQDIHSSLSQGST-SNWSRVLNEMAQVARIIV-ISAHGKVVRSLLIE 90

  Fly   259 QNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRK--------EKSKSLD---KISFRS 312
            .:::.|.:||::...                   .:||.:|        |:..|.|   |.::::
Zfish    91 AHKKGLTNGDFVFFC-------------------FEPYKQKVLFGSFDWEQGDSYDSMAKQAYQA 136

  Fly   313 VIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEV 377
            :..:|:..|.:...:.....:...: |..|...|.|.  :.:||.....|  |:|.:|..|:.|.
Zfish   137 LFFLSLYKPSDKRYQAFSENVISRS-KIDFGYTYAQT--EKVSVLAAIAH--DTVWLYAHALNET 196

  Fly   378 LRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSM 442
            |...|:.|||..|...::||:...||| ||.||::||.|.||.:..::   ||......:|
Zfish   197 LAENGNPYDGLAVTRRMWNRTIKGIQG-DVTIDASGDRELNYMMKQIR---GSNNQCQVVA---- 253

  Fly   443 QPVGFFAYDKNSVIPEFRYIKNDRPIQWLNG--RPPLAEPLCGFHGELCPRKKLDWRYLVS-GPL 504
               .:|.        .::.:|..: |.|..|  .||...|.|||.||||  ..|:.::|:: |.:
Zfish   254 ---NYFG--------TYKAVKGVQ-ILWPGGLTSPPKDSPDCGFRGELC--INLERKFLIALGII 304

  Fly   505 CALVV--VVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPT------NKNIFQICRQS 561
            ..|:.  .:||.:|.:.|:..:..:.:||.::..||.::   |:::.|      .....|...:|
Zfish   305 AGLMAAGTLAICVLYRKYKLPEEASKMLWTINANDVIMM---EHHSSTVPEKSHRSKPLQASLES 366

  Fly   562 ILVVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHG 626
            | :....:|.|....|:::|.|.::..::.:|..:...:..|||..|::.|.|:..||||:.:..
Zfish   367 I-ICSMQDKPSAHRTAVYKGTICSVSFVNLRSTHLNSELLAELKQFRDLTHYNLCKFIGAALETS 430

  Fly   627 SVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSR 691
            ...|.|.||.:|||:|:|.||.:.||..|..||:.||:|||.|||.|.:..||:|.||:|::|||
Zfish   431 QPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSSCVVDSR 495

  Fly   692 WVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIG 756
            :|.:::||||:.::....|.:.........|..||||||.:. |..|:||||||||.|:..|::.
Zfish   496 FVLKVTDFGLNSVRRLDTEQSPGSDPWTALLWRAPELLRQSI-PANGTQKGDVYSFAIIAQEVVY 559

  Fly   757 RKGPW--GDTAYSKEEIIQFVK---CPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVR 816
            |:||:  .::.:|..||::.|:   |...      ||.:...  :..:.:...:..||.|.|..|
Zfish   560 RRGPFYIPNSHFSPREIVERVRAGGCSPS------RPYIDRA--ECVEELESLVVSCWRETPAER 616

  Fly   817 PDIRLVRMHLKELQA-GLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPR 880
            ||...:|..:|:... |:..||.|::||.||:||.|||.:|.|||..|.||||:.:.||.|||||
Zfish   617 PDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPR 681

  Fly   881 PVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKV 945
            .||..|..|..|.||.:|||||.||||.|||.:..:.||.:||.:|||.||..|:||..::||||
Zfish   682 SVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKV 746

  Fly   946 ETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVV 1010
            ||||||||||||||::||..||.|||.::|.:::.:.:....|.|.:.:::|||||||||.||||
Zfish   747 ETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVV 811

  Fly  1011 GQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYW 1075
            |.||||||||||||||||||||.|..::||:|.:|..||....::.|..||...|||||.:||:|
Zfish   812 GLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIKGKGWVRTFW 876

  Fly  1076 L 1076
            |
Zfish   877 L 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	64/264 (24%)
		ANF_receptor	59..427	CDD:279440	61/243 (25%)
		PHA02988	534..826	CDD:165291	100/302 (33%)
		PK_GC-A_B	550..832	CDD:270944	98/293 (33%)
		HNOBA	<847..886	CDD:285003	23/38 (61%)
		CYCc	865..1057	CDD:214485	111/191 (58%)
		Guanylate_cyc	892..1076	CDD:278633	106/183 (58%)
si:dkey-37g12.1	XP_021333677.1	Periplasmic_Binding_Protein_Type_1	<59..258	CDD:324556	56/242 (23%)
		PKc_like	355..628	CDD:328722	96/282 (34%)
		HNOBA	<641..687	CDD:311573	27/45 (60%)
		CYCc	666..850	CDD:214485	109/183 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820