DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Gucy2d

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_077356.1	Gene:	Gucy2d / 79222	RGDID:	620438	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1161	Identity:	366/1161 - (31%)
Similarity:	563/1161 - (48%)	Gaps:	193/1161 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PGP----------CASAAAFSCILVLLLLGCQRSNPLAAGATVSSMRRL-TDTINIGFLAEYSQM 55
            |||          ..|.:|||.:..:.:||....:|:.|.|......|| ||.:|         .
  Rat    34 PGPGLPGLLLLLLLPSPSAFSAVFKVGVLGPWACDPIFARARPDLAARLATDRLN---------R 89

  Fly    56 RVTLGGLPLAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGP--D 118
            .:.|.|.|.....:...|.|.||        .:|...|        |:|:     |:..:||  .
  Rat    90 DLALDGGPWFEVTLLPEPCLTPG--------SLGAVSS--------ALTR-----VSGLVGPVNP 133

  Fly   119 ESCTTEALLASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPA-SKVSKSVISLLNAFHWNKFSI 182
            .:|....|||......::.:.|...         ..|.|.||| :..:.::..||.||.|.:.::
  Rat   134 AACRPAELLAQEAGVALVPWGCPGT---------RAAGTTAPAVTPAADALYVLLKAFRWARVAL 189

  Fly   183 VVSSKPIWGSDVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGE 247
            :.:.:.:| .:..||:.....||...::   .::..:|:  .||...:.:.......|:.|.|
  Rat   190 ITAPQDLW-VEAGRALSTALRARGLPVA---LVTSMVPS--DLSGAREALRRIRDGPRVRVVI-- 246

  Fly   248 HIAMV---DFVRGLQNRRLLESGDYIVVSVDDEI----YDSNRRVNIMERNYLDPYIRKEKSKSL 305
               ||   ..:.|.:.|.|||:.:.:.:: |..:    :|:...........|..::...|.:.
  Rat   247 ---MVMHSVLLGGEEQRYLLEAAEELGLT-DGSLVFLPFDTLHYALSPGPEALAAFVNSSKLRR- 306

  Fly   306 DKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIY 370
               :..:|:.::...|....::|...:.::: ::.|..:...|     :| |::|. :||:|.:.
  Rat   307 ---AHDAVLTLTRRCPPGGSVQDSLRRAQEH-QELPLDLDLKQ-----VS-PLFGT-IYDAVFLL 360

  Fly   371 VRAITEV-LRLGGDIYDGNLVMSHIFNRSYHSIQGFD-------------VYIDSNGDAEGNYTV 421
            ...:|.. ..:||....|..|.     |.....|.|.             |.:|::...|..:|.
  Rat   361 AGGVTRARAAVGGGWVSGASVA-----RQMREAQVFGFCGILGRTEEPSFVLLDTDAAGERLFTT 420

  Fly   422 ITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRP-PLAEPLCGFH 485
            ..|...:||..|.|:                              |:.:..|.| |..:|.|.|.
  Rat   421 HLLDPVLGSLRSAGT------------------------------PVHFPRGAPAPGPDPSCWFD 455

  Fly   486 GELCPRKKLDWRYLVSGPLCALVVVVAIALLIKHYRYE----QTLAG---LLWKVDMKDVTVINL 543
            .::.....::...:..|.|..:||.:..|.|..:.|:.    |.::|   ::  :.::|||.::
  Rat   456 PDVICNGGVEPGLVFVGFLLVIVVGLTGAFLAHYLRHRLLHMQMVSGPNKII--LTLEDVTFLH- 517

  Fly   544 GEYNNPTNKNIFQICRQSILVVGEPNKRSF-------TNIALFRGNIVAMKKI-HKKSVDITRSI 600
              ....:::.:.|..|.|:......:.||.       |||.|:.|:.|.:||. .:..:.|..:.
  Rat   518 --PQGGSSRKVAQGSRSSLATRSTSDIRSVPSQPQESTNIGLYEGDWVWLKKFPGEHHMAIRPAT 580

  Fly   601 RKELKLMREVRHENIINFIG----------ASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMF 655
            :.....:||:||||:..::|          |:...|.:.:.:.:||||||.|:||..|:.||.||
  Rat   581 KMAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQRDIKLDWMF 645

  Fly   656 ISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQE---EPNKSELE 717
            .|||:.|::|||.|||... ::||.|:|.||::|.|:|.:::|.|...|...|.   ||..:|.:
  Rat   646 KSSLLLDLIKGMRYLHHRG-VAHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSAEDQ 709

  Fly   718 LKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQ 782
                |..|||||||.....||:..|||:|.||::.|::.|..|:.....:.||:||.|:.|
  Rat   710 ----LWTAPELLRDPALERRGTLAGDVFSLGIIMQEVVCRSTPYAMLELTPEEVIQRVRSP---- 766

  Fly   783 HGVFRPALTHTHLDIPDYIRKC---LCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSI 844
                 |.|....:.:.....:|   :.|||.|.||:||.:.|.....|.:..|.|.||.|:||.:
  Rat   767 -----PPLCRPLVSMDQAPMECIQLMAQCWAEHPELRPSMDLTFDLFKGINKGRKTNIIDSMLRM 826

  Fly   845 MEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVG 909
            :|:|:.|||.|::|||..|.:||:|||.||.||||..|||.||.|..||.|.|:.||:.||||||
  Rat   827 LEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVG 891

  Fly   910 FTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLA 974
            ||.:...|.|.|||::|||.||..|:||.::||||||||||||||.||||.:||.|||.|||:::
  Rat   892 FTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMS 956

  Fly   975 LHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRI 1039
            |.:|..||:.::||.|...|::|||:|||||.|||||..|||||||||||||||||||||...||
  Rat   957 LDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRI 1021

  Fly  1040 HISEATYQLLQVIGSYVCIE-RGLTSIKGKGDMRTYWLTKR--------QQPELTP 1086
            |::.:|.::|:.:.....:| ||.|.:||||...||||..|        :.|:|.|
  Rat  1022 HVNMSTVRILRALDQGFQMECRGRTELKGKGVEDTYWLVGRVGFNKPIPKPPDLQP 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	80/427 (19%)
		ANF_receptor	59..427	CDD:279440	75/391 (19%)
		PHA02988	534..826	CDD:165291	103/315 (33%)
		PK_GC-A_B	550..832	CDD:270944	101/305 (33%)
		HNOBA	<847..886	CDD:285003	23/38 (61%)
		CYCc	865..1057	CDD:214485	117/191 (61%)
		Guanylate_cyc	892..1076	CDD:278633	110/184 (60%)
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594	88/443 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..552		5/31 (16%)
		PK_GC-2D	540..814	CDD:270945	98/287 (34%)
		HNOBA	<823..868	CDD:400168	26/44 (59%)
		CYCc	848..1039	CDD:214485	117/190 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1069..1108		3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820