DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	1133	Identity:	358/1133 - (31%)
Similarity:	549/1133 - (48%)	Gaps:	175/1133 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 INIGFLA------EYSQMRVTLG-GLPLAIEDVNKNPNLLPGKKLAFKPVDIG-------HKMSA 94
            :.:||.|      .:|..|  || ||...::.:|.            :||.:|       :..|.
Mouse    46 LTVGFHAPWNISHPFSVQR--LGAGLQTVVDKLNS------------EPVGLGNVSWEFTYTNST 96

  Fly    95 YRVKPLRA--MTQMREAGVTAFIGP--DESCTTEALLASAWNTPMLSFKCSDPIVSNKSTFHTFA 155
            ...|...|  :.|:::..::|..||  .|:.....||||.||.|:..|......:.:.....|..
Mouse    97 CSAKESLAVFIDQVQKEHISALFGPACPEAAEVIGLLASEWNIPLFDFVGQMAALKDHFWCDTCV 161

  Fly   156 RTLAPASKVSKSVISLLNAFHWNKFSIVVSSK---------PIWGSDVARAIQE-LAEARNFTIS 210
            ..:.|..::|..:...|....|....:...|.         .:||     |::: |....|.|.|
Mouse   162 TLVPPKQEISAVLRESLRYLGWEHIGVFGGSSADSSWEQVDEMWG-----AVEDGLQFHFNITAS 221

  Fly   211 HFKY---ISDYIPT-TKTLSQIDKII------EETYATTRIYVFIGEHIAMVDFVRGLQNRRLLE 265
             .:|   .||.:.. .:.:|.:.::|      |:.....:..|.:|                 |:
Mouse   222 -MRYNSSSSDLLQEGLRNMSYVARVIILICSSEDARRILQAAVDLG-----------------LD 268

  Fly   266 SGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKIS-MTYPQNPHIRDI 329
            :|:::.:.:..           :|.::....:.|:|.....|: :.||..|: ..|.........
Mouse   269 TGEFVFILLQQ-----------LEDSFWKEVLTKDKVIRFPKV-YESVFLIAPSAYGGGIGDDGF 321

  Fly   330 CSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHI 394
            ..::....|:.||    ...:.....|..|..:|:|::::|.:.:.|:.:...|..||..::|.:
Mouse   322 RKQVSQELRRPPF----QSSITSEDQVSPYSAYLHDALLLYAQTVEEMRKAEKDFRDGRQLISTL 382

  Fly   395 FNRSYHSIQGF--DVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDK-NSVI 456
             .....::||.  .|.:||.|....:|:|..||..       |:.:..    :.|..||. ..||
Mouse   383 -RAGQVTLQGITGPVLLDSQGKRHVDYSVYALQES-------GNRSLF----LPFLHYDSFQKVI 435

  Fly   457 PEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVV-AIALLIKHY 520
            ..:|   ||....|.:|..|..:|.||||.:||..|.    ..|:|....:..|: .:..|:  .
Mouse   436 RPWR---NDSNTSWPHGSLPEYKPGCGFHNDLCKTKP----PTVAGMTVTVTAVIPTVTFLV--L 491

  Fly   521 RYEQTLAGLL----------------WKVDMKDVTVI---NLGEYNNP-TNKNIFQI-------- 557
            .....:.||:                |::....:|::   .|.....| :.:|:...
Mouse   492 ASAAAITGLMLWRLRGKVQSHPGDTWWQIRYDSITLLPQHKLSHRGTPVSRRNVSDTSTVKASAD 556

  Fly   558 CRQSILVVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITR--SIRKELKLMREVRHENIINFIG 620
            | .|::...:..:..|..:.|::||.||:..|..::....:  ::|:|:.||.|::||||:.|.|
Mouse   557 C-GSLVKRHQDEELFFAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMCELKHENIVPFFG 620

  Fly   621 ASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSN 685
            ..|:..::.|.|.||.:|||:||:.|.|..:|.:|..|...||:.|:::||.|.:.|||||:.||
Mouse   621 VCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSN 685

  Fly   686 CLIDSRWVCQISDFGLHELKAG-------QEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGD 743
            ||:||....::|.|||.|.|.|       ||..:.|||     ...||||||....|..|:.:||
Mouse   686 CLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSEL-----YWTAPELLRLRESPCSGTPQGD 745

  Fly   744 VYSFGILLYEMIGRK--GPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLD--IPDYIRKC 804
            ||||.|||.::|.::  ||:.|...:.||||..:|.|.  .....||:|.....|  |...:|
Mouse   746 VYSFAILLRDLIHQQAHGPFEDLEAAPEEIISRIKDPR--APVPLRPSLLEDKGDGRIVALVR-- 806

  Fly   805 LCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKK 869
              :||||.||:||....::..|:|.......:|.|:|:..:|.||.:||.:|:|||..|..||:|
Mouse   807 --ECWDESPELRPIFPSIKKTLREASPRGHVSILDSMMGKLETYANHLEEVVEERTRELVAEKRK 869

  Fly   870 TDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCD 934
            .:.||..|||..|.|.|..|..||.|.|:.|||.||||||||:||:.|:|.:||::|||.|:..|
Mouse   870 VEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFD 934

  Fly   935 SIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIG 999
            ..|.::||||||||||||||.||||::||::||.|||::|||||....:.:|.|.|.|.::||||
Mouse   935 HTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVTTHFQIGHMPEERLKLRIG 999

  Fly  1000 VHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTS 1064
            :|:||..|||||..||||||||||||.||||||:...:|||:|::|...|...|.|...:||..|
Mouse  1000 LHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTIS 1064

  Fly  1065 IKGKGDMRTYWLTKRQ-----QPELTPD 1087
            :||||:..|:||..:.     .||.|.:
Mouse  1065 VKGKGEQTTFWLKGKDGFPVPLPEFTEE 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	84/444 (19%)
		ANF_receptor	59..427	CDD:279440	78/402 (19%)
		PHA02988	534..826	CDD:165291	109/316 (34%)
		PK_GC-A_B	550..832	CDD:270944	108/302 (36%)
		HNOBA	<847..886	CDD:285003	19/38 (50%)
		CYCc	865..1057	CDD:214485	111/191 (58%)
		Guanylate_cyc	892..1076	CDD:278633	107/183 (58%)
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595	88/453 (19%)
		PK_GC	555..829	CDD:270894	106/285 (37%)
		CYCc	865..1055	CDD:214485	110/189 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780