DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_076446.1	Gene:	Gucy1a2 / 66012	RGDID:	621655	Length:	730	Species:	Rattus norvegicus

Alignment Length:	286	Identity:	118/286 - (41%)
Similarity:	154/286 - (53%)	Gaps:	38/286 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   776 KCPEMLQHGVFRPALTHTHL-DIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFD 839
            |..|::..|:        || |||.:             :...|:.||....| .|.|||..: |
  Rat   427 KLDELIGRGL--------HLSDIPIH-------------DATRDVILVGEQAK-AQDGLKKRM-D 468

  Fly   840 NMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILF 904
            .:.:.:||....||           ||||||..|||.:.|..||:.|.:...|:|..||.||:||
  Rat   469 KLKATLEKTHQALE-----------EEKKKTVDLLYSIFPGDVAQQLWQRQQVQARKFDDVTMLF 522

  Fly   905 SDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGE 969
            |||||||.:|...||.:|:.|||:.||..|......|:||||||||||.|.|||. :....||..
  Rat   523 SDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLH-RKSLCHAKP 586

  Fly   970 IASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTG 1034
            ||.:||.::|.  :.::.......:|:|||:|||...|||||.:||||||||:.|..||:.||..
  Rat   587 IALMALKMMEL--SEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGS 649

  Fly  1035 DSMRIHISEATYQLLQVIGSYVCIER 1060
            ...||:||..|||||:...|:..|.|
  Rat   650 HPRRINISPTTYQLLKREDSFTFIPR 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	11/50 (22%)
		PK_GC-A_B	550..832	CDD:270944	13/56 (23%)
		HNOBA	<847..886	CDD:285003	15/38 (39%)
		CYCc	865..1057	CDD:214485	95/191 (50%)
		Guanylate_cyc	892..1076	CDD:278633	84/169 (50%)
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	31/107 (29%)
		CYCc	483..672	CDD:214485	95/191 (50%)
		Guanylate_cyc	512..696	CDD:278633	83/167 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810