DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Adcy5

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_072122.2	Gene:	Adcy5 / 64532	RGDID:	71014	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	874	Identity:	179/874 - (20%)
Similarity:	309/874 - (35%)	Gaps:	317/874 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 GLHLYDSVMIYVRAITEV---LRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTV 421
            |:.:.:::.: ||.:|.|   :|:|  |:.|.:....:..|.:.    |||:  ||.
  Rat   542 GMDMIEAISL-VREVTGVNVNMRVG--IHSGRVHCGVLGLRKWQ----FDVW--SND-------- 589

  Fly   422 ITLQNDVGSGASIG--SLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGF 484
            :||.|.:.:|...|  .:.|.::                 .|:..|..:          ||.||
  Rat   590 VTLANHMEAGGKAGRIHITKATL-----------------NYLNGDYEV----------EPGCG- 626

  Fly   485 HGE----------------LCPRKKLDWRYLVS------------GPLCALVVVVAIALLIKHYR 521
             ||                .|.:|:.:.:.:::            .|              .|:.
  Rat   627 -GERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNP--------------PHWG 676

  Fly   522 YEQT----LAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALFRGN 582
            .|:.    |.|.....:||     .:| :.:|.:||            .:.:......:..|.|
  Rat   677 AERPFYNHLGGNQVSKEMK-----RMG-FEDPKDKN------------AQESANPEDEVDEFLG- 722

  Fly   583 IVAMKKIHKKSVDITRS--IRKELKLMRE------------------------------------ 609
                :.|..:|:|..||  :||.|...||
  Rat   723 ----RAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITI 783

  Fly   610 VRHE--------------NIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLV 660
            |.|.              .::.||  |..:..|.:|.|.....|.:.|.:.::        |:||
  Rat   784 VPHSLFMLSFYLSCFLLLALVVFI--SVIYACVKLFPTPLQTLSRKIVRSKKN--------STLV 838

  Fly   661 SDILKGMIYLHDSEIISHGNLRSSN---CLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRAL 722
            ......:::|  |..::.....|.|   ||.:.           |.:...|..
  Rat   839 GVFTITLVFL--SAFVNMFMCNSKNLVGCLAEE-----------HNITVNQVN------------ 878

  Fly   723 CMAPELLRDAYRPGRGSQKG------------DVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFV 775
              |..::..|:....|.::|            :.:::.:||                     ..:
  Rat   879 --ACHVMESAFNYSLGDEQGFCGSPQSNCNFPEYFTYSVLL---------------------SLL 920

  Fly   776 KCPEMLQHG-----VFRPALTHTH---LDIP-----------------DYIRKCLCQCWDEDPEV 815
            .|...||..     |...|:...:   :::|                 |:......||    ||
  Rat   921 ACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQC----PE- 980

  Fly   816 RPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLY-----EEKKKTD---- 871
                ...::.||.    :.|.|....:..:..:|..:|...  |.:.|:     |||::.:
  Rat   981 ----HATKVALKV----VTPIIISVFVLALYLHAQQVESTA--RLDFLWKLQATEEKEEMEELQA 1035

  Fly   872 ---MLLYQMLPRPVAELL----KRGDPVEAECFDCVTILFSDIVGFT----ELCTTSTPFEVVEM 925
               .||:.:||:.||...    :|.|.:..:..:||.::|:.|..|:    ||...:...|.:.:
  Rat  1036 YNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRL 1100

  Fly   926 LNDWYTCCDSIISN---YDVYKVETIGDAYMVVSGLPLQN----GSRHAGEIASLALHLLETVGN 983
            ||:.....|.|||.   ..:.|::|||..||..|||....    |..|...:|..|:.|::   .
  Rat  1101 LNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTHIKALADFAMKLMD---Q 1162

  Fly   984 LK-IRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQ 1047
            :| |........|::||::.||..|||:|.:.|:|.::|:|||.||||:|||...||.::...||
  Rat  1163 MKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQ 1227

  Fly  1048 LLQVIGSYVCIERGLTSIKGKGDMRTYWL 1076
            :| ...:|....||:..:||||:|.||:|
  Rat  1228 VL-AANTYQLECRGVVKVKGKGEMMTYFL 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	21/92 (23%)
		ANF_receptor	59..427	CDD:279440	17/69 (25%)
		PHA02988	534..826	CDD:165291	56/383 (15%)
		PK_GC-A_B	550..832	CDD:270944	54/373 (14%)
		HNOBA	<847..886	CDD:285003	13/50 (26%)
		CYCc	865..1057	CDD:214485	69/214 (32%)
		Guanylate_cyc	892..1076	CDD:278633	67/195 (34%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..196
		Guanylate_cyc	461..634	CDD:306677	29/137 (21%)
		DUF1053	669..761	CDD:399378	23/128 (18%)
		Guanylate_cyc	1063..1257	CDD:306677	68/197 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810