DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Gucy1a1

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001343916.1	Gene:	Gucy1a1 / 60596	MGIID:	1926562	Length:	691	Species:	Mus musculus

Alignment Length:	690	Identity:	174/690 - (25%)
Similarity:	279/690 - (40%)	Gaps:	212/690 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 YEQTLAGLLWKVDMKDVTVINLG----------EYNNPTN--KNIFQICRQSILVVGEPNKRSFT 574
            |..|||..:.|:...:...:||.          |.|..::  :::.:|..:..:..|.|
Mouse    70 YLHTLAESICKLIFPECERLNLALQRTLAKHKIEENRKSSEKEDLEKIIAEEAIAAGAP------ 128

  Fly   575 NIALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGAS-----TDHGSVIIFTTY 634
                    :.|:|.          |:.:||..:.....|:|:..:|.:     ....:::..:::
Mouse   129 --------VEALKD----------SLGEELFKICYEEDEHILGVVGGTLKDFLNSFSTLLKQSSH 175

  Fly   635 C----ARGSLED---VLANED---LHLDHMFISSLVSDILKGMI-----YLHDSEI--------- 675
            |    .||.|||   :..::|   |::.:.|.....:.:|.|:|     .|::|.:
Mouse   176 CQEAERRGRLEDASILCLDKDQDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCF 240

  Fly   676 -------------------------ISHGNLRSSNCLIDSRWVCQISDF---------------G 700
                                     :|.|..:|| .:|.:...|:...|               |
Mouse   241 RSDCTEFVNQPYLLYSVHVKSTKPSLSPGKPQSS-LVIPASLFCKTFPFHFMLDRDLAILQLGNG 304

  Fly   701 LHEL---KAGQEEPNKSE-LELKRALCMAPELLRDAYRPGRGSQKGDVYSFGI---LLYEMIGRK 758
            :..|   :..|.:||..| .|:     :.|::             ...:| ||   |..:.:.|.
Mouse   305 IRRLVNKRDFQGKPNFEEFFEI-----LTPKI-------------NQTFS-GIMTMLNMQFVIRV 350

  Fly   759 GPWGDTAYS-------KEEIIQFVK----------CPEMLQ----HGVFRPALTHTHLDIPDYIR 802
            ..|.::...       |.::|..|:          |.:.|:    .|::..       |||  |.
Mouse   351 RRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLS-------DIP--IH 406

  Fly   803 KCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEK 867
            ..|           .|:.|:....: .|.|||            |....|:..::.....|.|||
Mouse   407 NAL-----------RDVVLIGEQAR-AQDGLK------------KRLGKLKATLEHAHQALEEEK 447

  Fly   868 KKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTC 932
            |:|..||..:.|..||:.|.:|..|:|:.|..||:|||||||||.:|:..:|.:|:.|||..||.
Mouse   448 KRTVDLLCSIFPSEVAQQLWQGQIVQAKKFSEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTR 512

  Fly   933 CDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLR 997
            .|......||||||||||||.|..||..::.: ||.:||.:||.::|....:...|  .|.:::|
Mouse   513 FDQQCGELDVYKVETIGDAYCVAGGLHRESDT-HAVQIALMALKMMELSNEVMSPH--GEPIKMR 574

  Fly   998 IGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGL 1062
            ||:|||...|||||.|||||||||:.|..|::.||.....:|::|..||:||:
Mouse   575 IGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLK------------ 627

  Fly  1063 TSIKGKGDMRTYWLTKRQQPELTPDLISTV----DTLDTY 1098
                   |...:..|.|.:.||.|:..|.:    ..||.|
Mouse   628 -------DCPGFVFTPRSREELPPNFPSDIPGICHFLDAY 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	63/400 (16%)
		PK_GC-A_B	550..832	CDD:270944	60/380 (16%)
		HNOBA	<847..886	CDD:285003	13/38 (34%)
		CYCc	865..1057	CDD:214485	89/191 (47%)
		Guanylate_cyc	892..1076	CDD:278633	78/183 (43%)
Gucy1a1	NP_001343916.1	HNOBA	277..466	CDD:311573	47/240 (20%)
Gucy1a1	NP_001343916.1	Guanylate_cyc	472..643	CDD:306677	81/192 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810