DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Phlpp1

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	XP_038946976.1	Gene:	Phlpp1 / 59265	RGDID:	621308	Length:	1718	Species:	Rattus norvegicus

Alignment Length:	890	Identity:	166/890 - (18%)
Similarity:	273/890 - (30%)	Gaps:	300/890 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 WLNGR-----------PPLAEPLCGFHGELCPRKKLD-------------------WRYLVSGPL 504
            |..||           |.|...|   |||...|.:.|                   ||....|
  Rat   416 WTPGRIRETVQKTSSPPSLYVQL---HGETTRRLEADEKPLQIQNDYLFQLGFGELWRVQEEG-- 475

  Fly   505 CALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTN---KNIFQICRQSILV-- 564
                :...|..||:.|..:....|...::.:..:..:..|:...|.|   :....:|...::|
  Rat   476 ----MDSEIGCLIRFYAGKPHSTGSSERIQLSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSS 536

  Fly   565 VGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITRS-------------IRKELKLMREVRHENII 616
            |.:.:......:.|..|.:..:|| |:..:..:.|             ..:.|:.:|:|...
  Rat   537 VKDSSSGKMHVLPLIGGKVEEVKK-HQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKV--- 597

  Fly   617 NFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGN- 680
                ||....||.:  :.|   |||.:.||                    :.|..|   ::|.|
  Rat   598 ----ASQRISSVDL--SCC---SLEHLPAN--------------------LFYSQD---LTHLNL 630

  Fly   681 ----LRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKR--------ALCMAPEL----- 728
                ||.:..|..:|        ||.||   |.......|.|..        |:|..|.|
  Rat   631 KQNFLRQNPSLPAAR--------GLGEL---QRFTKLKSLNLSNNHLGAFPSAVCSIPTLAELNV 684

  Fly   729 ----LRDAYRPGRGSQKGDVYSF---GILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVF 786
                ||:.  |.......::.:|   |..|..:..........:|......:|...||:|:
  Rat   685 SCNALREV--PAAVGAMQNLQTFLLDGNFLQSLPAELENMHQLSYLGLSFNEFTDIPEVLE---- 743

  Fly   787 RPALTHTHLDIPDYIRKCL----CQCWDEDPEVR-PDIR------LVRMHLKELQAGLKPNIFDN 840
                ..|.:|.......|:    .|.....|.:: .|:|      |:...:..||...:.::.||
  Rat   744 ----KLTAVDKLCMAGNCMETLRLQALRRMPHIKHVDLRLNILRKLITDEVDFLQHVTQLDLRDN 804

  Fly   841 MLSIMEKYAY-NLEGLVQERTNL------------LYEEKKKTDMLLYQMLPRPVAELLKRGDPV 892
            .|..::...: |:|.|..||..|            ||....:    |.|:...||...|...| |
  Rat   805 KLGDLDAMIFNNIEVLHCERNQLVTLNICGYFLKALYASSNE----LVQLDVYPVPNYLSYMD-V 864

  Fly   893 EAECFDCVTILFSDI-------VGFTELC------------------------------TTSTPF 920
            ...|.:.|.....:.       :|..::|                              .||...
  Rat   865 SRNCLESVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNRLARLPERLERTSVEV 929

  Fly   921 ------EVVEMLNDWYTCCDSI-ISNYDVYKVETIGDAYM------VVSGLPLQNGSRHAGEIAS 972
                  :::|:..:.....||: ..|....|:||:..|.:      ::..|.|.|.|     :..
  Rat   930 LDVQHNQIIELPPNLLMKADSLRFLNASANKLETLPPATLSEETSSILQELYLTNNS-----LTD 989

  Fly   973 LALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGD-------TVNTASRM 1030
            ..:.||.....|||.|.....:|      |.|.:.....:::....:.|:       |:....||
  Rat   990 KCVPLLTGHPRLKILHMAYNRLQ------SFPASKMAKLEELEEIDISGNKLKAIPTTIMNCRRM 1048

  Fly  1031 EST-GDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKG----------------DMRTYWLTK 1078
            .:. ..|..|.:.....||.:|           .|.:|.|                |:....|::
  Rat  1049 HTVIAHSNCIEVFPEVMQLPEV-----------KSTEGNGSLSRSSFLFPLFHQCVDLSCNELSE 1102

  Fly  1079 RQQPELTPDLISTVDTLDTYCSGPR-----ESMEVSVHQYC----SPASNNYRLGSCNCDTKCLY 1134
            ...||..|..:..:|    ....||     :|:|:..:..|    .|::.:
  Rat  1103 ITLPENLPPKLQELD----LTGNPRLALDHKSLELLNNIRCFKIDQPSAGD-------------- 1149

  Fly  1135 SRRSDDNVTNSHGTSEFPKVSEPAQVNCNQLCVCRLNSSQMFNNR 1179
              .|......|||.:|...|.       |:|||..|:.:...:||
  Rat  1150 --ASGAPAVWSHGYTEASGVK-------NKLCVAALSVNNFRDNR 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	63/345 (18%)
		PK_GC-A_B	550..832	CDD:270944	63/335 (19%)
		HNOBA	<847..886	CDD:285003	12/51 (24%)
		CYCc	865..1057	CDD:214485	43/249 (17%)
		Guanylate_cyc	892..1076	CDD:278633	41/257 (16%)
Phlpp1	XP_038946976.1	Ubiquitin_like_fold	176..>224	CDD:421700
		PHA03247	<237..443	CDD:223021	9/29 (31%)
		RA_PHLPP1	<424..491	CDD:340760	15/75 (20%)
		PH_PHLPP-like	498..594	CDD:270131	14/96 (15%)
		PLN00113	602..>1109	CDD:215061	109/582 (19%)
		leucine-rich repeat	604..624	CDD:275380	9/44 (20%)
		leucine-rich repeat	625..655	CDD:275380	11/40 (28%)
		leucine-rich repeat	679..701	CDD:275380	4/23 (17%)
		leucine-rich repeat	702..724	CDD:275380	3/21 (14%)
		leucine-rich repeat	725..771	CDD:275380	9/53 (17%)
		leucine-rich repeat	772..795	CDD:275380	4/22 (18%)
		leucine-rich repeat	796..816	CDD:275380	3/19 (16%)
		leucine-rich repeat	817..858	CDD:275380	11/44 (25%)
		leucine-rich repeat	859..881	CDD:275380	5/22 (23%)
		leucine-rich repeat	882..904	CDD:275380	2/21 (10%)
		leucine-rich repeat	905..926	CDD:275380	0/20 (0%)
		leucine-rich repeat	927..950	CDD:275380	1/22 (5%)
		leucine-rich repeat	951..974	CDD:275380	5/22 (23%)
		leucine-rich repeat	977..1000	CDD:275380	6/27 (22%)
		leucine-rich repeat	1001..1024	CDD:275380	7/28 (25%)
		leucine-rich repeat	1067..1112	CDD:275380	10/55 (18%)
		PP2Cc	1151..1403	CDD:214625	13/42 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900