Protein Alignment Gyc32E and gucy2ca

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: XP_073799927.1
• Gene: gucy2ca / 572052
• ZFINID: ZDB-GENE-091118-67
• Length: 1071
• Species: Danio rerio
• Alignment Length: 1195
• Identity: 362/1195 - (30%)
• Similarity: 544/1195 - (45%)
• Gaps: 265/1195 - (22%)

  Fly    10 AFSCILVLLLLGCQRSNPLAAGATVSSMRRLTDTINIGFLAEYS---QMRVTLGGLPLAIEDVNK 71
            |..|...:.|||       .:|..|.|.|..:.|:|:..|.:.:   .::.....:..|:||.|
Zfish     5 ALLCFCWVSLLG-------VSGFNVLSCRNSSVTLNVVLLEDENSPWSLKFVKDVVETAVEDQN- 61

  Fly    72 NPNLLPGKKLAFKPVDIGHKMSAYR-----------VKPLRAMTQMREAGVTAFIGPDESCTTEA 125
            |.|...|.....|.:..|...:.||           |:.|:::....|.| ...:||  |||
Zfish    62 NKNHAEGLDFHIKVLFSGFNTTHYRRRGCGSSTCEAVEILKSLHNNSELG-CVMLGP--SCT--- 120

  Fly   126 LLASAWNTPMLSFKCSD---------PIVSNKSTF-------HTFARTLAPASKVSKSVISLLNA 174
                     ..:|:..|         ||:| ..:|       ....|.|.||.|:::..
Zfish   121 ---------YATFQLVDQEVGLTLTIPIIS-AGSFGLSCDYKQKLTRLLPPARKIAEFF------ 169

  Fly   175 FH-WNKFSIVVSSKPIWGSDVARAIQELAEARNFTISHFKYISDY-IPTTKTLSQIDK--IIEET 235
            || |:  :.|.:.||.|.:      ..:.:..|:|...|.||:.. .|:....|.|.:  :..|:
Zfish   170 FHFWH--TSVKNLKPAWKT------AYVYKKDNYTEECFWYINALEAPSALFSSNISREMLRSES 226

  Fly   236 YATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRR-------VNIMERNYL 293
            ..:|.:                  .|:...|...::....|:||...:.       |.|:...|.
Zfish   227 ELSTAL------------------KRKDRHSNIIVMCGTPDDIYTIKKNNTVPSQVVFILIDLYN 273

  Fly   294 DPYIRKEKSKSLDKISFRSVIKISM----TYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNI 354
            :.|...|.|.:    ..|:|:.::|    .|..|...|:..:.:.||      :|.||
Zfish   274 EGYRTNESSPA----HMRNVLVLTMHSFRNYSSNSVWRNNTTALNDY------VVGYH------- 321

  Fly   355 SVPIYGLHLYDSVMIYVRAITEVL-RLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGN 418
                      |:|:::..|:...| |:.......:.:.....|.|::.|.|: ..:||:||.:.|
Zfish   322 ----------DAVVLFGNAMRNNLQRIKQQQGLSDNIDPPFRNMSFYGIGGY-YKLDSSGDRDLN 375

  Fly   419 YTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRP-IQWLNGRPPLAEPLC 482
            .:|:         .:.||....::     |::|.:.   ....:|:..| :.|  .|..|
Zfish   376 LSVV---------YTTGSYKYRTL-----FSFDTSQ---NRTKVKDSSPDLPW--DRSQL----- 416

  Fly   483 GFHGELCPRKK------LDWRYLVSGPLCALVVVVAIALLIKHYR-------YEQTLAGLLWKVD 534
                   ||.|      .:...:|.|....|..|:|..|..::.|       :....:.|:..:|
Zfish   417 -------PRDKHTGMEIQEIMMIVLGLSVVLATVIAFILYRQNRRVRFDQKKWSHISSSLITPLD 474

  Fly   535 MKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITRS 599
            .|:...|:|....:....|      .|::..|..:|:.           |.:|::.....:.|..
Zfish   475 DKERNYISLTIDEDKKGDN------SSLIRKGRYDKKP-----------VILKELRNTDGNFTDD 522

  Fly   600 IRKELKLMREVRHENIINFIG-ASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFIS-----S 658
            .|.||..:..:.:.|:..|.| ...|.|...:| .:|.||||..||.::..:.|..|:.     |
Zfish   523 QRIELNALLRIDYYNLTKFYGTVRFDCGVFGVF-EFCERGSLRYVLDDKISYPDASFMDLEFRIS 586

  Fly   659 LVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALC 723
            ::.||.|||.|||.|.:..||.|:|:||::|:|.|.:|:|||.:.:.:    |.|.       |.
Zfish   587 VMYDIAKGMSYLHSSNVGVHGRLKSTNCVVDNRMVVKITDFGCNTILS----PGKD-------LW 640

  Fly   724 MAPELLRDAYRPGRG-SQKGDVYSFGILLYEMIGRKGPWGDTAYS----KEEIIQFVKCPEMLQH 783
            .|||.:|     ..| |||||||||.|:..|:|.||.|:..:..|    |..::|:.:.|
Zfish   641 TAPEHMR-----VEGISQKGDVYSFAIISQEIILRKSPFHTSCCSDMAEKLYLVQYPRGP----- 695

  Fly   784 GVFRPALT-----HTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGL----KPNIFD 839
            .||||.|:     .|..::...|:    .||:||||.|||.:.:...|.::.:.|    ..:..|
Zfish   696 NVFRPDLSFEGVGETEAELFVLIK----SCWEEDPEKRPDFKRIEGALGKIFSNLHNQANASYMD 756

  Fly   840 NMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILF 904
            |::..::.|:.|||.||:|||.|...|:.:.|.|.:.:||.||...||....||.|.:|.|||.|
Zfish   757 NLIRRLQMYSRNLEHLVEERTALYKAERDRADQLNFMLLPGPVVRSLKETGRVEPELYDEVTIYF 821

  Fly   905 SDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGE 969
            |||||||.:|..|||.|||:||||.|...|||:.::||||||||||||||.||||..||:|||.:
Zfish   822 SDIVGFTTICHHSTPMEVVDMLNDIYKNFDSILDHHDVYKVETIGDAYMVASGLPRCNGNRHAVD 886

  Fly   970 IASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTG 1034
            |..:||.:||.:|..::||.|...:.:|||:|||||||||||.||||||||||||||||||||||
Zfish   887 ICLMALDILEFMGTFQLRHLPGIPLWIRIGIHSGPCAAGVVGNKMPRYCLFGDTVNTASRMESTG 951

  Fly  1035 DSMRIHISEATYQLLQVIG-SYVCIERGLTSIKGKGDMRTYWLT------------------KRQ 1080
            ..:|||:||:|.::||... .:.|..||.|.:||||...|||||                  :|.
Zfish   952 LPLRIHVSESTIKILQRTDCEFECERRGETFLKGKGKEMTYWLTGVTGQKYSLPTPPTVENFQRL 1016

  Fly  1081 QPELTPDLISTVD--------TLDT 1097
            |.:|...::||::        ||.|
Zfish  1017 QQDLAERIVSTLNKRGNERRKTLST 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	89/449 (20%)
		PK_GC-A_B	550..832	CDD:270944	92/297 (31%)
		CYCc	865..1057	CDD:214485	115/192 (60%)
gucy2ca	XP_073799927.1	None