Protein Alignment Gyc32E and adcy1b

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: XP_073776301.1
• Gene: adcy1b / 569499
• ZFINID: ZDB-GENE-100805-1
• Length: 1121
• Species: Danio rerio
• Alignment Length: 1125
• Identity: 233/1125 - (20%)
• Similarity: 385/1125 - (34%)
• Gaps: 368/1125 - (32%)

  Fly   219 IPTTKTLSQIDKIIEETYATTRIYV-----FIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEI 278
            :|...||.....:.:.|....|..|     |.|.:::.: |||.|..|
Zfish   169 LPLAHTLITASALPDNTQRLWRSLVANTLLFTGVNVSGL-FVRILTER----------------- 215

  Fly   279 YDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFL 343
              :.|:..:..||.::..:|.|......:....|::.           |::..::|:...|.|
Zfish   216 --AQRKAFLQARNCIEERLRMEDENEKQERLLMSLLP-----------RNVAMEMKEDFLKPP-- 265

  Fly   344 VPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLV--MSHIFNRSYHSIQGFD 406
                :|:|..|.:     ..:|:|.|....|.....|........||  ::.:|.:       ||
Zfish   266 ----ERIFHKIYI-----QRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGK-------FD 314

  Fly   407 VYIDSN--------GDAEGNYTVITLQNDVGSGASIGSLAKMSMQP----------VGFFAYDKN 453
            .....|        ||.  .|.|        ||.:         ||          :|....|..
Zfish   315 ELATENHCRRIKILGDC--YYCV--------SGLT---------QPKTDHAHCCVEMGLDMIDTI 360

  Fly   454 SVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAIALLIK 518
            :.:.|...:..:..:....||     .|||..|   .||   |:|.|
Zfish   361 TSVAEATEVDLNMRVGLHTGR-----VLCGVLG---LRK---WQYDV------------------ 396

  Fly   519 HYRYEQTLA------GLLWKVDMKDVTVINL-GEY----NNPTNKNIFQICR--QSILVVGEPNK 570
             :..:.|||      ||..||.:...|:..| |:|    .|...::.|.:..  ::..:|....:
Zfish   397 -WSNDVTLANMMEAGGLPGKVHITRSTLECLNGDYEVEPGNGRERHAFLLKHDIETFFIVPSHRR 460

  Fly   571 RSFTNIALFRGNIVAMKKIHKKSV-----------------------------DITRSIRKELKL 606
            :.|..:.|  .:|...||:..|:|                             |..|.:|...:.
Zfish   461 KIFPGLIL--SDIKPAKKMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMNCEDGDKRRVLRSAPEK 523

  Fly   607 MRE--------------VRHENIINFI--GASTDHGSV-IIFTTYCARGSLEDVLANE--DLHLD 652
            :|.              .|....||.:  ...|:..:. :.:.|...|.|..:...::  |.:..
Zfish   524 LRNRTPTTASAPQSSPGTRVNRYINRLIEARQTESDTADLNYLTLMYRDSERERRYHQLNDEYFT 588

  Fly   653 HMFISSLVSDILKGMIYLHDSEIISHGN-----LRSSNCLIDSRWVCQISDFGLHELKAGQEEPN 712
            ...:.||:..:|.|.:||   .||..|.     |....|.:   .||.:.   ||..:. |..|.
Zfish   589 GAVVLSLLLVVLLGFLYL---LIIPQGTVVLVLLVFCICFL---VVCIMY---LHITRV-QCFPG 643

  Fly   713 KSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRK-----GPWGDTAYSKEEII 772
            ...::::.|||:                      |.:||...:.:.     .||...:.|...|:
Zfish   644 CLTIQIRTALCV----------------------FIVLLIYAVAQACVVGCMPWLWPSNSTRSIV 686

  Fly   773 ----------------------QFVKC----------------PEM-------------LQHGVF 786
                                  .|:.|                |:|             |:...|
Zfish   687 IIDAAAGLNRTMAELPCAGAQYAFLCCMLGTLSMALFLRVSWIPKMILLLLLLVLYITILELSGF 751

  Fly   787 RPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRL------VRMHLKELQAGLKPNIFDNMLSIM 845
            |.|.....|.:..               :.|.:.|      |.:|.::|...|:.:..
Zfish   752 RRASGWALLSVRG---------------LEPLLSLLLFSTAVALHSRQLDLKLRLDFL------- 794

  Fly   846 EKYAYNLEGLVQERTNLLYEEKKKTD--MLLYQMLPRPVAELLKRGDP-----------VEAECF 897
              :|...|   :||..:   ||.|.|  .:|:.:||..||:.....:|           :..:.:
Zfish   795 --WATQAE---EERDGM---EKVKLDNKRILFNLLPVHVAQHFLLSNPRNMVRSSEHQDLYYQSY 851

  Fly   898 DCVTILFSDIVGFT----ELCTTSTPFEVVEMLNDWYTCCDSIISN---YDVYKVETIGDAYMVV 955
            ..|.:||:.|..|.    ||...:...|.:.:||:.....|.::..   .|:.|::|||..||..
Zfish   852 AQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKECYKDIEKIKTIGSTYMSA 916

  Fly   956 SGLPLQNGSR-------HAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQK 1013
            .||....|::       |...||..|:.:.:.:.  :|.::......||:|::.||..|||:|.:
Zfish   917 VGLVPTIGTKAKKSTATHLSTIADFAIEMFDVLD--EINYQSYNDFVLRVGINVGPVVAGVIGAR 979

  Fly  1014 MPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLT- 1077
            .|:|.::|:|||.||||:|||...:|.::|..|:|||  .:|..:.||..|:||||.|.||:|.
Zfish   980 RPQYDIWGNTVNVASRMDSTGVPGKIQVTEDVYRLLQ--NNYDLMCRGNVSVKGKGQMLTYFLEG 1042

  Fly  1078 KRQQPELTPDLISTVDTLDTYCSGPRES--MEVSVHQYCSPASNNYRLGSCNCDTKCLYSRRS-D 1139
            |.|.|.:               ..|..:  :|..||.....:|...:.||.:..|..|..|.. .
Zfish  1043 KAQDPGI---------------RAPHHTGGLERRVHAIARTSSTQTKAGSVSSATSGLAVRVGLS 1092

  Fly  1140 DNVTNSHG---TSEFPKVSE 1156
            .:....||   |:..|.|.|
Zfish  1093 SSFHGPHGHSNTTNVPTVGE 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	46/253 (18%)
		PK_GC-A_B	550..832	CDD:270944	62/398 (16%)
		CYCc	865..1057	CDD:214485	65/218 (30%)
adcy1b	XP_073776301.1	None