DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and gucy2cb

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	XP_021329920.1	Gene:	gucy2cb / 568219	ZFINID:	ZDB-GENE-130531-31	Length:	1071	Species:	Danio rerio

Alignment Length:	1043	Identity:	324/1043 - (31%)
Similarity:	483/1043 - (46%)	Gaps:	210/1043 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 VKPLRAMTQMREAGVTAFIGPDESCTTEALLASAWNTPMLSFKCSD---------PIVSNKS--- 149
            |:.|..:....|.| .|.:||  :||            ..:|:.:|         ||:|..|
Zfish    97 VEILNDLANAGEEG-CALLGP--TCT------------YATFQMADLEIGLNLNMPIISAGSFGL 146

  Fly   150 ---TFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWGSDVARAIQELAEARNFTISH 211
               ......|.|.||.|:|...|:.     | ||...|  ||.|.:      ..|.:..:.|...
Zfish   147 SCDLKRDLTRLLPPARKISSFFINF-----W-KFHDPV--KPKWET------AYLYKKPDNTEDC 197

  Fly   212 FKYIS-------DYIPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDY 269
            |.||:       .:.|:.:.:..|....:.|.|..:                  .||   ||..:
Zfish   198 FWYINALEVSNGGFSPSLQEIEVIRNKEDLTKAMAK------------------HNR---ESNLF 241

  Fly   270 IVVSVDDEI---------YDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPH 325
            |:....|:|         |||.....:::. |.|.|.:.:.:..:     |:|:.::|     |:
Zfish   242 ILCGTPDDIMDLKNGTTDYDSEIAFLLIDL-YNDIYYKGQSNTFM-----RNVLVLTM-----PN 295

  Fly   326 IRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEVLRLGG-DIYDGNL 389
            .|..............::..||                 |:|:::.:.:..:.:.|. ||.|...
Zfish   296 TRKYTIDTSGNNTMNDYIAAYH-----------------DAVLLFGQVMRNIQKSGSLDIQDMES 343

  Fly   390 V-MSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKN 453
            | |::..|.|:..|.| :..:|.:||.:..:::|...|:                       ::.
Zfish   344 VSMNYFRNVSFTGIAG-EYQLDQHGDRDLMFSLIYTNNN-----------------------NQY 384

  Fly   454 SVIPEFRYIKNDRPIQ-------WLNGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVV 511
            :::.:|....|...::       |.:..|           ...|.|.|....::...||.::.::
Zfish   385 NILYQFNTSNNKTGLKDSSPSFIWQSRLP-----------NDSPSKGLSVIEIIVIVLCTVIGIM 438

  Fly   512 AIALLI-----KHYRYEQTLAGLLWK-VDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNK 570
            .....|     ::|.:.|.    .|. :..:.:|.:.|.|:|            ...|.:.|.:.
Zfish   439 GTLAFIFYWQNRYYHHMQK----RWSHISSQLITPLELNEWN------------MISLKIEEDST 487

  Fly   571 RSFTNI---ALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFT 632
            .:.|.|   |.:...||.:|:........|...|.||..:.::.:.|:..|.|............
Zfish   488 ENSTYILRRARYDKKIVILKEFRLTDGSFTEKQRIELNTLLKIDYCNLTKFYGTVKFDNEYFGVF 552

  Fly   633 TYCARGSLEDVLAN-----EDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRW 692
            .|..||||..||.:     |:..:|..|..|::.||.|||.|||.|.|..||.|:|:||::|:|.
Zfish   553 EYGERGSLRYVLDDKISYPEETFMDWQFKISVMYDIAKGMSYLHTSNIAVHGRLKSTNCVVDNRM 617

  Fly   693 VCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGR 757
            |.:|:|||.:.:.:..|:           |..|||.||   :||. |||||||||.|:..|::.|
Zfish   618 VVKIADFGFNTIVSPSED-----------LWTAPEHLR---KPGI-SQKGDVYSFAIISQEIMMR 667

  Fly   758 KGP-WGDTAYSKEEIIQFVKCPEMLQHGVFRPALT-HTHLDIPDYIRKCLCQCWDEDPEVRPDIR 820
            |.. :.:|...:.|.:..|:.|...  ..|||.|. .:..:..:.:...:..||||||:.|||.:
Zfish   668 KCTFYTNTCSDRAEKLARVQYPSTT--SFFRPDLNFESTSESEEEVCMLIRNCWDEDPDRRPDFK 730

  Fly   821 LVRMHLKELQAGLKPN-----IFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPR 880
            .:.:.|.::.:  :.|     ..:|::..::.|:.|||.||:|||.|...|:.:.|.|.:.:||.
Zfish   731 KIEIALWKIVS--RDNQEHESYMENLIRRLQMYSRNLERLVEERTALYKAERDRADCLNFMLLPG 793

  Fly   881 PVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKV 945
            ||...||....||.|.||.|||.||||||||.||..|||.|||:||||.|...|||:.|:|||||
Zfish   794 PVVRSLKETGKVEPELFDEVTIYFSDIVGFTTLCHFSTPMEVVDMLNDIYKNFDSILDNHDVYKV 858

  Fly   946 ETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVV 1010
            ||||||||||||||.:||:|||.:|..:||.:|..:|.:::.|.|...|.:||||||||||||||
Zfish   859 ETIGDAYMVVSGLPRRNGNRHAKDICLMALDILAFMGTIQLSHLPGIPVWIRIGVHSGPCAAGVV 923

  Fly  1011 GQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIG-SYVCIERGLTSIKGKGDMRTY 1074
            |.||||||||||||||||||||||..:|||:|::|..:||... .:...|||.|.:||||...||
Zfish   924 GIKMPRYCLFGDTVNTASRMESTGLPLRIHVSQSTINILQRTDCKFEYEERGETFLKGKGKEMTY 988

  Fly  1075 WLT 1077
            |||
Zfish   989 WLT 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	75/383 (20%)
		ANF_receptor	59..427	CDD:279440	74/362 (20%)
		PHA02988	534..826	CDD:165291	92/301 (31%)
		PK_GC-A_B	550..832	CDD:270944	89/291 (31%)
		HNOBA	<847..886	CDD:285003	17/38 (45%)
		CYCc	865..1057	CDD:214485	118/192 (61%)
		Guanylate_cyc	892..1076	CDD:278633	119/184 (65%)
gucy2cb	XP_021329920.1	Periplasmic_Binding_Protein_Type_1	33..408	CDD:324556	77/412 (19%)
		PKc_like	471..741	CDD:328722	92/298 (31%)
		CYCc	778..970	CDD:214485	118/191 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920