DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and gucy1b2

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	XP_685297.5	Gene:	gucy1b2 / 557191	ZFINID:	ZDB-GENE-130530-664	Length:	757	Species:	Danio rerio

Alignment Length:	906	Identity:	213/906 - (23%)
Similarity:	329/906 - (36%)	Gaps:	325/906 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 IDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNY 292
            |::..|||:...|:             :.|:|.           ..:..||||....:.:::
Zfish    14 IERFGEETWENLRL-------------MAGVQE-----------TFMTYEIYDDIITLRLVQ--- 51

  Fly   293 LDPYIRKEKSKSLDKISFRSVIKISMTY--------PQNPHIRDICSKIKDYARKTPFLVPYHQR 349
                   |..|.|| :|...|:|:...|        ..:..:|.:...:.::......|..|...
Zfish    52 -------EACKMLD-VSSEVVLKLFGEYFFSFCKMSGYDTMLRTLGGNLVEFIENLDALHSYLAL 108

  Fly   350 VFDNISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRS--YHSIQGF------D 406
            .::.::.|.:.:...|                    ||.:::.:..:|.  ||.:.|.      |
Zfish   109 SYEAMNAPSFRVERMD--------------------DGRILLHYYSDRKGLYHIVPGIIEAVAKD 153

  Fly   407 VYIDSNGDAEGNYTVIT-LQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVI------------PE 458
            .:     |:|...|::. .:.|..:|         ..:.|.|....|..|.            .|
Zfish   154 FF-----DSEVTMTILNQSEEDERTG---------KKEHVVFHMVQKEKVTKRKAQTRQNNSEEE 204

  Fly   459 FRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAIALLIKHYRYE 523
            ...:|.|:.......:...|      :.:|||||:..|..:
Zfish   205 ILEVKKDKEETMRRMKARYA------NLQLCPRKRSPWELV------------------------ 239

  Fly   524 QTLAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALFRGNIVAMKK 588
                                                :||:::|:.|.|.
Zfish   240 ------------------------------------RSIVMLGQGNLRQ---------------- 252

  Fly   589 IHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDH 653
                  ..|.|..|.|.:..:.       |..|...|   |:|              :.||.:.|
Zfish   253 ------SFTPSYPKTLWIEEQA-------FCNAFPFH---IVF--------------DSDLVVKH 287

  Fly   654 --MFISSLVSDILKGMIYLHDSEIISHG----NLRSSNCLIDSRWVCQISDFGLHELKAGQE--- 709
              :.|...|..:....|.|.:...|.|.    |::|....|:|::|          ||..:|
Zfish   288 TGVNIQKFVPGLQTAGIRLDEYFTIVHPEVIFNIQSIKKFINSQFV----------LKTRREMLP 342

  Fly   710 --EPNKSELELKRAL-------CM----APELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPW 761
              :.|:..|:|:..:       ||    :|:|........||....|:
Zfish   343 EVQQNQPTLKLRGQMMWMESLNCMIYLCSPKLRSLQELEERGLHLADI----------------- 390

  Fly   762 GDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHL 826
                               .||...|        |:                     |.|.:..|
Zfish   391 -------------------AQHDTTR--------DL---------------------ILLNQQRL 407

  Fly   827 KELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDP 891
            .|::...:.......|.|:.:   |||           .||:|::.|||.|||..||..||.|..
Zfish   408 AEIELSNQLERKKEELRILSR---NLE-----------IEKQKSEKLLYAMLPTHVANQLKEGKR 458

  Fly   892 VEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVS 956
            |||..|...||||||:|.||.:|....|.::|.|||..|:..|.:.|.::||||||||||||||.
Zfish   459 VEAGEFKVCTILFSDVVTFTNICAACEPIQIVNMLNAMYSRFDRLTSIHNVYKVETIGDAYMVVG 523

  Fly   957 GLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPT-ETVQLRIGVHSGPCAAGVVGQKMPRYCLF 1020
            |:|:...: ||..:|:.||.:  .:...::.:..| :.:|:|:|:|:||..|||||:||||||||
Zfish   524 GVPVPTNT-HAERVANFALGM--RIAAREVTNPITGQPIQIRVGLHTGPVLAGVVGEKMPRYCLF 585

  Fly  1021 GDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKRQQ 1081
            ||||||||||||.|....||:|..|:.:::..|.:...|||...:||||.||||:|.|..|
Zfish   586 GDTVNTASRMESHGVPDHIHVSPFTFSVIKDKGIFEMAERGEIEVKGKGLMRTYFLLKNLQ 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	37/236 (16%)
		ANF_receptor	59..427	CDD:279440	34/215 (16%)
		PHA02988	534..826	CDD:165291	47/313 (15%)
		PK_GC-A_B	550..832	CDD:270944	49/303 (16%)
		HNOBA	<847..886	CDD:285003	14/38 (37%)
		CYCc	865..1057	CDD:214485	95/192 (49%)
		Guanylate_cyc	892..1076	CDD:278633	92/184 (50%)
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002	33/208 (16%)
		CAF-1_p150	<166..277	CDD:288454	28/217 (13%)
		HNOBA	269..453	CDD:285003	56/289 (19%)
		CYCc	432..618	CDD:214485	94/188 (50%)
		Guanylate_cyc	459..642	CDD:278633	92/185 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810