DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and Adcy4

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_062158.2	Gene:	Adcy4 / 54223	RGDID:	2034	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	361	Identity:	102/361 - (28%)
Similarity:	168/361 - (46%)	Gaps:	79/361 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   771 IIQFVKCPEMLQHGVFRPAL--------------THTHLDIPDYIRKCL-CQCWDEDPEVRPDIR 820
            ::.|:.| .:..|..|...|              .|:|..:.|    || .:.:......||.:
  Rat   723 VLGFLSC-SLFLHMSFELKLLLLLLWLVASCSLFLHSHAWLSD----CLIARLYQGSLGSRPGV- 781

  Fly   821 LVRMHLKE--LQAGLKPNIFDNMLSIM---EKYAYNLEGLVQERTNLLYEEKKKTD-------ML 873
                 |||  |...:...||...|.::   .:|...|:.|.:::   |.:|:::|:       :|
  Rat   782 -----LKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKK---LRQEREETETMENLTRLL 838

  Fly   874 LYQMLPRPVAELL----KRGDPVEAECFDCVTILFSDIVGFTELCTTST----PFEVVEMLNDWY 930
            |..:||..||...    :|.:.:..:.::||.:||:.|..|.|..:.|.    ..|.:.:||:
  Rat   839 LENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASIPDFKEFYSESNINHEGLECLRLLNE-- 901

  Fly   931 TCCDSIISNYD----------VYKVETIGDAYMVVSGLPLQNGS----------RHAGEIASLAL 975
                 ||:::|          |.|::|||..||..:||....|.          .|.|.:...|:
  Rat   902 -----IIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATPGQDTQQDAERSCSHLGTMVEFAV 961

  Fly   976 HLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIH 1040
            .|...:|.:. :|. ....:||:|::.||..|||:|.:.|:|.::|:|||.||||||||...:|.
  Rat   962 ALGSKLGVIN-KHS-FNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQ 1024

  Fly  1041 ISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWL 1076
            ::|.|.:.||.:| |.|..||:..:||||.:.||:|
  Rat  1025 VTEETARALQSLG-YTCYSRGVIKVKGKGQLCTYFL 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	12/69 (17%)
		PK_GC-A_B	550..832	CDD:270944	16/77 (21%)
		HNOBA	<847..886	CDD:285003	12/45 (27%)
		CYCc	865..1057	CDD:214485	69/226 (31%)
		Guanylate_cyc	892..1076	CDD:278633	69/207 (33%)
Adcy4	NP_062158.2	AC_N	<115..246	CDD:292831
		CYCc	219..422	CDD:214485
		Guanylate_cyc	264..430	CDD:278633
		DUF1053	479..580	CDD:283888
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..523
		CYCc	824..1039	CDD:214485	68/224 (30%)
		Guanylate_cyc	861..1060	CDD:278633	70/209 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810