DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and ACXE

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster

Alignment Length:	1078	Identity:	204/1078 - (18%)
Similarity:	356/1078 - (33%)	Gaps:	377/1078 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 VFDNISVPIYGLH--------LYDSVMIYVRAITEVLRLGGDIY--------DGNLVMSHIFNRS 398
            ||.:::..||..:        .||:.:||:            ||        .|.::::.:.:..
  Fly   122 VFADLTESIYHTYAHSWILGTFYDTYIIYM------------IYMFLPIHFISGAVLLALLVSGL 174

  Fly   399 YHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFF------------AYD 451
            |  |..|.::|     |:|.....:....|| |.|:..:..:.:..||.|            ..|
  Fly   175 Y--ILYFVIFI-----AQGFAQFASALFSVG-GMSVDIVHYLCLNLVGIFYRVMNDTVVRSSFLD 231

  Fly   452 KNSVIPEFRYIKNDR-----------------PIQW-LNGRPPLAEPLCGFHG----------EL 488
            ::..|.|..:::|.|                 |:|. :.||..:|:.  |.|.          ::
  Fly   232 RHQYIKEKIWLRNARLQEKQLLDSILPPQISLPLQKDIQGRIVMAKQ--GIHSWTAMERTMAIQI 294

  Fly   489 CPRKKLDWRYLVSGPLCALVVVVAIALLIK--HYRYEQ-TLAGLLWKVDMKDVTVINLGEYNNPT 550
            .|...:.:..:|:  ...|...:.:.:|:|  |..|.: .||...:||.    .:..||:
  Fly   295 HPDVSILYADVVN--YTHLTTTLTVEMLVKVLHDLYGRFDLAAYRYKVQ----RIKFLGD----- 348

  Fly   551 NKNIFQICRQSILVVGEPNKRSFTNIALFR----GNIVAMKKIHKKSVDITRSIRK--------- 602
                   |...:..:.:|:.....|..:..    .:|:.::.||...:::...:..
  Fly   349 -------CYYCVAGLSDPDPDHANNCVILGLSMINHIMEVRDIHGLDINMRIGVHSGNLFAGVIG 406

  Fly   603 ELKLM-----REVRHENI---------INFIGASTDHGSVIIFTTYCARGSLED----------- 642
            |.||.     .:|...|:         ::..||:.::..|       .|..:||
  Fly   407 EAKLQFDIWGLDVTIANVLESTGVPGCVHISGATLNNLDV-------NRFDIEDGPEEARDHPLL 464

  Fly   643 -------VLANEDLHLD----HMFISSLVSDILKGM---IYLHDS-----EIISHGNLRSSNCLI 688
                   .:..:|||:|    ..|:..|.|..|..|   ..:.||     ..:.|..||.
  Fly   465 KKYRIRSYIIRQDLHMDDEDSDEFLGDLHSISLCNMGAQPRISDSANQSLRALFHEELRE----- 524

  Fly   689 DSRWVCQISDF------GLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSF 747
            :.|.: .:|.|      |:.....|:|.|....|.:  .|.....:|..||.    .|...:|.:
  Fly   525 EFRKM-PVSAFSPKRLLGICRFNTGKEVPAHQNLNI--CLTFTDPILERAYL----KQTDYMYKY 582

  Fly   748 GILLYEMIG--------------------------------------RKGPWGDTAYSKEEI--- 771
            .|:|...:|                                      :|..|  |.|.:..:
  Fly   583 SIILSASVGCSLVYIELMDTQMICSSCFVLPASVATIQCILALIAWYKKYCW--TRYGRNNVPHH 645

  Fly   772 IQFVKCPEMLQHGVFRPAL-----THTHLDIPDYIRKCL--CQCWDEDPEVRPDIRLVRMHLKEL 829
            .....|.....|.....:|     .:..|.|..:...||  ..|..|:.|:......:..:.:|.
  Fly   646 YNGFSCFIFRIHDKILNSLPIRICIYLFLMISSFFVMCLIVMSCQREEFEMAYIEERLFHYEQEA 710

  Fly   830 QAGLKPNIFDNMLSIM------------------------------------------------- 845
            .....|.:..||||:|
  Fly   711 HICFHPWVTTNMLSLMICLTFTFAHIPIMVKTAVAILETLAYLLLIFFQFDFVFHHSVTTNPYFK 775

  Fly   846 EKYAYN-------LEGLVQER----TNL--------LYEEKKKTDM-------LLYQMLPRPVAE 884
            .:||:.       |...|:||    ||.        |.:|:....:       :|..:||..:.:
  Fly   776 SEYAHALLICITFLIMFVKERQIEFTNKVNFNWRVDLRKEENAASLTNHSIIIILNNILPSHIVD 840

  Fly   885 LLKRG---DPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSII----SNYDV 942
            :....   ..:..|.:..|:::|:.::.| |:...|     :.:||:.....|:::    ..|.|
  Fly   841 VYLNSLAKHELYFENYRMVSVMFAMLINF-EMDLRS-----LRVLNEIIAEFDTLLLFYKEYYTV 899

  Fly   943 YKVETIGDAYMVVSGLPL-----------------------------QNGSRHAGEI----ASLA 974
            .|::.:|..||...||.|                             |..:....|:    .|.|
  Fly   900 EKIKIVGCTYMAACGLDLNFAGSTSTNRKESIPPTEFNEEQSRRILFQQSNEDLDEVVFVMTSYA 964

  Fly   975 LHLLETVGNLKIRHKPTETVQ------------LRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTA 1027
            |.::.|:.      |..|..|            :.||:.||...||:||...|.|.::|:.||.|
  Fly   965 LDMMRTLA------KSNEAYQSIAGDRNITDGTIAIGISSGEVMAGIVGASQPHYDIWGNPVNMA 1023

  Fly  1028 SRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKRQQPELTPDLISTV 1092
            |||||||....||::|.|.::||..| ..|..||:|.:||:|.:.||.:...:.....|...:
  Fly  1024 SRMESTGLPGHIHVTEETSEILQQFG-ITCSYRGMTFVKGRGKIPTYLVGIDENLNFIPQKAT-- 1085

  Fly  1093 DTLDTYCSGPRESMEVSVHQYCSPASNNYRLGSCNCDT 1130
                .:.|....|..:|:....:.|.||..:.|.:..|
  Fly  1086 ----RFPSHQERSTVISLQSTYTHAENNNSIASTSRHT 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	23/113 (20%)
		ANF_receptor	59..427	CDD:279440	17/92 (18%)
		PHA02988	534..826	CDD:165291	64/402 (16%)
		PK_GC-A_B	550..832	CDD:270944	63/392 (16%)
		HNOBA	<847..886	CDD:285003	13/64 (20%)
		CYCc	865..1057	CDD:214485	59/250 (24%)
		Guanylate_cyc	892..1076	CDD:278633	64/232 (28%)
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454	31/169 (18%)
		Nucleotidyl_cyc_III	290..459	CDD:325147	30/193 (16%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147	64/232 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453893
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740