DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and NPR3

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001191304.1	Gene:	NPR3 / 4883	HGNCID:	7945	Length:	541	Species:	Homo sapiens

Alignment Length:	478	Identity:	109/478 - (22%)
Similarity:	204/478 - (42%)	Gaps:	68/478 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AIEDVNKNPN----LLPGKK--LAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGP--DESC 121
            |:..|..|..    |.||.:  :|::..|.|::.....|..:.|   .|.|.....:||  :.:.
Human    79 ALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRVAA---ARGAKPDLILGPVCEYAA 140

  Fly   122 TTEALLASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPA-SKVSKSVISLLNAFHWNKFSIVVS 185
            ...|.|||.|:.||||.........:|.:.::....:||| :|:.:.:::|....||::.::|.|
Human   141 APVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYS 205

  Fly   186 SKPIWGS--DVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEH 248
            ...:..:  .....:.|:.:......|.:.:     ..||.| .::.|:....|:.|:.:.
Human   206 DDKLERNCYFTLEGVHEVFQEEGLHTSIYSF-----DETKDL-DLEDIVRNIQASERVVIM---- 260

  Fly   249 IAMVDFVRGLQ---NRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLD-PYIRKEKSKSLDKIS 309
            .|..|.:|.:.   :|..:.||||...::  |:::|:        :|.| .:.|.:|.....|.:
Human   261 CASSDTIRSIMLVAHRHGMTSGDYAFFNI--ELFNSS--------SYGDGSWKRGDKHDFEAKQA 315

  Fly   310 FRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAI 374
            :.|:..:::.....|.......::|....|...      .:.|.:::.:.|.|  |::::||.|:
Human   316 YSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGL------NMEDYVNMFVEGFH--DAILLYVLAL 372

  Fly   375 TEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGAS------ 433
            .||||.|....||..::...:||::..|.| .|.||:|||..|:::||.: .||.:|..
Human   373 HEVLRAGYSKKDGGKIIQQTWNRTFEGIAG-QVSIDANGDRYGDFSVIAM-TDVEAGTQEVIGDY 435

  Fly   434 IGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLDWRY 498
            .|...:..|:|...:.:.     |....|..:|.::..|..|      |...|.|   ::.....
Human   436 FGKEGRFEMRPNVKYPWG-----PLKLRIDENRIVEHTNSSP------CKSSGGL---EESAVTG 486

  Fly   499 LVSGPLCALVVVVAIALLIKHYR 521
            :|.|.|....:::|.....|.||
Human   487 IVVGALLGAGLLMAFYFFRKKYR 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	94/403 (23%)
		ANF_receptor	59..427	CDD:279440	88/376 (23%)
		PHA02988	534..826	CDD:165291
		PK_GC-A_B	550..832	CDD:270944
		HNOBA	<847..886	CDD:285003
		CYCc	865..1057	CDD:214485
		Guanylate_cyc	892..1076	CDD:278633
NPR3	NP_001191304.1	PBP1_NPR_C_like	54..446	CDD:107381	93/399 (23%)
		ANF_receptor	71..422	CDD:279440	88/375 (23%)
		TM_EphA1	476..507	CDD:214014	6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810