Protein Alignment Gyc32E and NPR1

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_000897.3
• Gene: NPR1 / 4881
• HGNCID: 7943
• Length: 1061
• Species: Homo sapiens
• Alignment Length: 1154
• Identity: 399/1154 - (34%)
• Similarity: 591/1154 - (51%)
• Gaps: 181/1154 - (15%)

  Fly     1 MPGPCASAAAFSCILVLLLLGCQRSNPL--------AAGATVSSMRRLTDTINIGFLAEYSQMRV 57
            ||||...|.:...:|:||||     .||        |...||:.:..|.:|       .|.....
Human     1 MPGPRRPAGSRLRLLLLLLL-----PPLLLLLRGSHAGNLTVAVVLPLANT-------SYPWSWA 53

  Fly    58 TLG-GLPLAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYRV-----KPLRAMTQMREAGVTAFIG 116
            .:| .:.||:..|...|:||||..:.   ..:|...:|..|     .||.|:....|.....|:|
Human    54 RVGPAVELALAQVKARPDLLPGWTVR---TVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLG 115

  Fly   117 PDESCTTEAL----LASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHW 177
            |  .|...|.    ..:.|..|:|:..........|..:....|.....:|:...|.:|.....|
Human   116 P--GCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGW 178

  Fly   178 NKFSIVV-SSKPIWGSD------VARAIQELAEARNFTISHFKY----ISDYIPTTKTLSQIDKI 231
            .:.:::: :.:|  |.:      |......:.:..|.|:.|.::    :|.|....:|:.:..::
Human   179 ERQALMLYAYRP--GDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRV 241

  Fly   232 I-----EETYATTRI-----------YVFIGEHIAMVDFVRGLQN------RRLLESGDYIVVSV 274
            |     .:.:.|..:           |||.  |:.:  |.:.||.      ||..|.||...||.
Human   242 IYICSSPDAFRTLMLLALEAGLCGEDYVFF--HLDI--FGQSLQGGQGPAPRRPWERGDGQDVSA 302

  Fly   275 DDEIYDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARK 339
                                            :.:|::...|:...|.||...:...::|..|
Human   303 --------------------------------RQAFQAAKIITYKDPDNPEYLEFLKQLKHLA-- 333

  Fly   340 TPFLVPYHQRVF---DNI--SVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSY 399
                  |.|..|   |.:  ::|   ...:|.:::|::|:||.|..||.:.||..:...::|||:
Human   334 ------YEQFNFTMEDGLVNTIP---ASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSF 389

  Fly   400 HSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKN 464
            ..:.|: :.|||:||.|.::::..:..:.|:                            ||.:.|
Human   390 QGVTGY-LKIDSSGDRETDFSLWDMDPENGA----------------------------FRVVLN 425

  Fly   465 ------------DRPIQWLNGRPPLAEPLCGFHGE--LCPRKKLDWRYLVS--GPLCALVVVVAI 513
                        .|.:.|..|.||...|.|||..|  .|.:..|....:::  |.|..|.:::..
Human   426 YNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVS 490

  Fly   514 ALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQS---ILVVGEPNKRSFTN 575
            ..:.:..:.|:.||..||:|..:||...:|..:.......:....|.|   .|:..|...:.|..
Human   491 FFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAK 555

  Fly   576 IALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSL 640
            .|.::||:||:|::::|.:::||.:..|||.||:|::|::..|:||.||..::.|.|.||.||||
Human   556 TAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSL 620

  Fly   641 EDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELK 705
            :|:|.||.:.||.||..||.:||:|||::||:..|.|||||:||||::|.|:|.:|:|:||...:
Human   621 QDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR 685

  Fly   706 AGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPW--GDTAYSK 768
              ..:|.:......:.|..||||||.|..|.||||.||||||||:|.|:..|.|.:  .....|.
Human   686 --DLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSP 748

  Fly   769 EEIIQFVKCPEMLQHGVFRPALT-HTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAG 832
            :|||:.|...|   ...|||:|. .:||   :.:...:.:||.|||:.||..:.:|:.|::....
Human   749 KEIIERVTRGE---QPPFRPSLALQSHL---EELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRE 807

  Fly   833 LKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECF 897
            ...||.||:||.||:||.|||.||:|||....|||:|.:.||||:||..|||.||||:.|:||.|
Human   808 NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAF 872

  Fly   898 DCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQN 962
            |.|||.||||||||.|...|||.:||.:|||.|||.|::|.|:|||||||||||||||||||::|
Human   873 DSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRN 937

  Fly   963 GSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTA 1027
            |..||.|:|.:||.||:.|.:.:|||:|.|.::||||:|:||..|||||.|||||||||||||||
Human   938 GRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTA 1002

  Fly  1028 SRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWL 1076
            |||||.|::::||:|..|..:|:..|.:....||...:||||.:|||||
Human  1003 SRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWL 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	89/451 (20%)
		PK_GC-A_B	550..832	CDD:270944	115/287 (40%)
		CYCc	865..1057	CDD:214485	122/191 (64%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:380608	97/496 (20%)
		PK_GC-A_B	534..807	CDD:270944	115/280 (41%)
		HNOBA	<813..861	CDD:462234	29/47 (62%)
		CYCc	840..1032	CDD:214485	122/191 (64%)