DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Adcy1

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_033752.1	Gene:	Adcy1 / 432530	MGIID:	99677	Length:	1118	Species:	Mus musculus

Alignment Length:	1234	Identity:	255/1234 - (20%)
Similarity:	435/1234 - (35%)	Gaps:	394/1234 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CQRSNPLAAGATVSSMRRLTDTINIGFLAEYSQMRVTLGGLPLAIEDVNKNPNLLPGKKLAFKPV 86
            |.....|..|.|:    ||.....:..||..|    .|.| .||:.::...|...||......||
Mouse    41 CPELEALFRGYTL----RLEQAATLKALAVLS----LLAG-ALALAELLGAPGPAPGLAKGSHPV 96

  Fly    87 DIGHKMSAYRVKPLRAM--TQMREAGVTAFI---------------GPDESCTTEALLAS----- 129
            .....::.:.|..:|::  :|:::.|..|..               ||..|....|:.::
Mouse    97 HCILFLALFVVTNVRSLQVSQLQQVGQLALFFSLTFALLCCPFALGGPARSSAGGAMGSTVAEQG 161

  Fly   130 AWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWGSDV 194
            .|...::             ||.::|  |.|.    :|::::       .|.:||::
Mouse   162 VWQLLLV-------------TFVSYA--LLPV----RSLLAI-------GFGLVVAA-------- 192

  Fly   195 ARAIQELAEARNFTISHFKYISDYIPTT-----KTLSQIDKIIEETYATTRIYVFIGEHIAMVDF 254
                           ||....:..:|..     :||.            ....:|.|.::..| |
Mouse   193 ---------------SHLLVTAALVPAKRPRLWRTLG------------ANALLFFGVNMYGV-F 229

  Fly   255 VRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMT 319
            ||.|..|                   |.|:..:..||.::..:|.|......:....|::.
Mouse   230 VRILTER-------------------SQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLP---- 271

  Fly   320 YPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEVLRLGGDI 384
                   |::..::|:...|.|      :|:|..|.:     ..:|:|.|....|.....|....
Mouse   272 -------RNVAMEMKEDFLKPP------ERIFHKIYI-----QRHDNVSILFADIVGFTGLASQC 318

  Fly   385 YDGNLV--MSHIFNRSYHSIQGFDVYIDSN--------GDAEGNYTVITLQNDVGSGASIGSLAK 439
            ....||  ::.:|.:       ||.....|        ||.  .|.|        ||.:
Mouse   319 TAQELVKLLNELFGK-------FDELATENHCRRIKILGDC--YYCV--------SGLT------ 360

  Fly   440 MSMQP----------VGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKL 494
               ||          :|....|..:.:.|...:..:..:....||     .|||..|   .||
Mouse   361 ---QPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGR-----VLCGVLG---LRK-- 412

  Fly   495 DWRYLV-SGPLCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINL-GEY----NNPTNKN 553
             |:|.| |..:....|:.|              |||..||.:...|:..| |:|    .:...:|
Mouse   413 -WQYDVWSNDVTLANVMEA--------------AGLPGKVHITKTTLACLNGDYEVEPGHGHERN 462

  Fly   554 IF-----------------QICRQSILVVGEPNKR-SFTNIALFRGNIVAMKKIHKKSVDITRSI 600
            .|                 :|....||...:|.|| .|..:......::..:|:.|..:..:..:
Mouse   463 TFLRTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVM 527

  Fly   601 -------RKELKLMREVRHENIINFIGASTDHGSVIIFTT-------YCAR--GSLEDVLANEDL 649
                   |:.|:    ...|.:.|....||:    :::||       |.:|  .:.:..|...||
Mouse   528 TCEDDDKRRALR----TASEKLRNRSSFSTN----VVYTTPGTRVNRYISRLLEARQTELEMADL 584

  Fly   650 HL------------------DHMFISSLVSDI----LKGMIYLHDSEIISHGNLRSSNCLIDSRW 692
            :.                  |..|.|::|..:    |.|:|||    ::...::.....|:.|
Mouse   585 NFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILAALFGLIYL----LVIPQSVAVLLLLVFS-- 643

  Fly   693 VCQISDFGLH-ELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIG 756
            :|.:....|: .:...|..|....::::.|||:...:|  .|...:|...|.:
Mouse   644 ICFLVACTLYLHITRVQCFPGCLTIQIRTALCVFIVVL--IYSVAQGCVVGCL------------ 694

  Fly   757 RKGPWGDTAYSKEEIIQFVKCPEMLQHGVFR---PAL----THTHLDIPDYIRKCLCQCWDEDPE 814
               ||..::.|...::       :|..|..|   |||    .|..|         || |......
Mouse   695 ---PWAWSSQSNSSLV-------VLAAGGRRTVLPALPCESAHHAL---------LC-CLVGTLP 739

  Fly   815 VRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEG------------------------- 854
            :...:|:..:....|.:||.    .:.:.::|...|...|
Mouse   740 LAIFLRVSSLPKMILLSGLT----TSYILVLELSGYTKVGGGALSGRSYEPIMAILLFSCTLALH 800

  Fly   855 --LVQERTNLLY-----EEKKKTDM---------LLYQMLPRPVAELLKRGDP----VEAECFDC 899
              .|..|..|.|     .|:::.||         :|:.:||..||:.....:|    :..:.:..
Mouse   801 ARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQ 865

  Fly   900 VTILFSDIVGFT----ELCTTSTPFEVVEMLNDWYTCCDSIISN---YDVYKVETIGDAYMVVSG 957
            |.::|:.|..|.    ||...:...|.:.:||:.....|.::..   .|:.|::|||..||...|
Mouse   866 VGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVG 930

  Fly   958 LPLQNGSR-------HAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMP 1015
            |....|:|       |...:|..|:.:.:.:.  :|.::......||:|::.||..|||:|.:.|
Mouse   931 LAPTAGTRAKKSISSHLCTLADFAIDMFDVLD--EINYQSYNDFVLRVGINVGPVVAGVIGARRP 993

  Fly  1016 RYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKR 1079
            :|.::|:|||.||||:|||...||.::|..::||:.. ||..:.||..|:||||:|.||:|..|
Mouse   994 QYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLKRC-SYQFVCRGKVSVKGKGEMLTYFLEGR 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	78/450 (17%)
		ANF_receptor	59..427	CDD:279440	70/404 (17%)
		PHA02988	534..826	CDD:165291	65/360 (18%)
		PK_GC-A_B	550..832	CDD:270944	62/345 (18%)
		HNOBA	<847..886	CDD:285003	14/79 (18%)
		CYCc	865..1057	CDD:214485	63/218 (29%)
		Guanylate_cyc	892..1076	CDD:278633	64/197 (32%)
Adcy1	NP_033752.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		AC_N	<158..291	CDD:292831	35/230 (15%)
		CYCc	257..452	CDD:214485	52/267 (19%)
		Guanylate_cyc	293..475	CDD:278633	48/237 (20%)
		Interaction with calmodulin. /evidence=ECO:0000250	492..519		5/26 (19%)
		CYCc	825..1036	CDD:214485	61/213 (29%)
		Guanylate_cyc	858..1055	CDD:278633	65/199 (33%)
		Interaction with calmodulin. /evidence=ECO:0000250	1023..1046		9/23 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810