DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and CG43373

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster

Alignment Length:	922	Identity:	204/922 - (22%)
Similarity:	319/922 - (34%)	Gaps:	303/922 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   489 CPRKKL--DWRYLVSG--------PLCA----LVVVVAIALL-------------IKHYRYEQTL 526
            |.|.||  |..|.|||        ..||    |.::.||||:             |...|....:
  Fly   772 CLRIKLLGDCYYCVSGLPEPRPDHAHCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGV 836

  Fly   527 AGLL-WKVDM--KDVTVINLGEYNNPTNKNIFQICRQSI--------LVVGEPNKRS-------F 573
            .||: |:.|:  .|||:.|..|......:  ..|.::::        :.||:.|:|:       .
  Fly   837 LGLVKWQFDVWSNDVTLANHMESGGIPGR--VHITKETLKCLDGDYEVEVGKGNERNSYLKDHQI 899

  Fly   574 TNIALFRGNIVAMKKIHKKS---VDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYC 635
            ....:..|:|.   :.||||   :.:..:|.|||::|                .||:....|:..
  Fly   900 ETYLIVPGDIY---RPHKKSRNRLQVNGNISKELRMM----------------GHGTAQKHTSKF 945

  Fly   636 ARG-SLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDF 699
            ..| |.|.....||          .|::.|...|   |:..|.|  ||:.:|  .|..:| ..|.
  Fly   946 GFGDSSESAKDPED----------EVNEYLMRAI---DARSIDH--LRAEHC--QSLLLC-FKDN 992

  Fly   700 GLHELKAGQEEPNKS-------------ELELKRALCMAPELLRDAYRPGRGSQKG--------- 742
            .|....|  .||::.             ...:.|.:.....||..|...|.....|
  Fly   993 VLERKYA--SEPDRMLCVYFYCSLLVLLGTSIMRLVVFQSSLLTLALSTGALLLLGFLVFLVACH 1055

  Fly   743 --------DVYSFGILLY---------------------------------EMIGRKGPWGDT-- 764
                    |:..|.:.::                                 |::.|:..|.|.
  Fly  1056 KINFQLPSDIKRFSLRIHSNRRISQLFAFASVALIVLTTLLAMFQESGRQMELLQRRRFWLDVNG 1120

  Fly   765 ------------AYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRP 817
                        .|..||    ..|...|.:..|   |..|.|.:..      |..:
  Fly  1121 SISLNDTELNTKMYDAEE----PDCDFYLAYNTF---LLLTLLSMMS------CATY-------- 1164

  Fly   818 DIRLVRMHLKEL--------QAGLKPNIFDNMLSIMEKYAYNLEGLVQ----------------- 857
              :::|:.||.|        ......|::.....:.::.| |.|.|::
  Fly  1165 --QVLRILLKLLLLLLASGSYMACSSNLYSRSREMSQELA-NEEALLRYIIDSIFLFAFMLALIF 1226

  Fly   858 --ERTNLLYE---------EKKKTDM---------LLYQMLPRPVAELL----KRGDPVEAECFD 898
              .:|...|.         .::|.||         ||..:||..|||..    |..|.:..|..|
  Fly  1227 HSHQTEATYRLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCD 1291

  Fly   899 CVTILFSDIVGFT----ELCTTSTPFEVVEMLNDWYTCCDSIISNYD----------VYKVETIG 949
            .|.|||:.|..|:    ||...:...|.:.:||:       ||:::|          :.|:::.|
  Fly  1292 SVCILFASIPNFSEFYVELEGNNEGVECLRLLNE-------IIADFDELLSEERFRCIEKIKSTG 1349

  Fly   950 DAYMVVSGLPLQNGSR----HAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVV 1010
            ..||..|||......|    |...:|..||.|.:.:..:.:.  .....::|||::.||..|||:
  Fly  1350 ATYMAASGLTANTCDRVNFSHVTAMADYALQLFDKIEEVNMH--SFNNFRMRIGINIGPVVAGVI 1412

  Fly  1011 GQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIG-SYVCIERGLTSIKGKGDMRTY 1074
            |...|:|.::|:.||.||||:|||....|.:::...|:|:..| ...|  ||...:||||.|.||
  Fly  1413 GACKPQYDIWGNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGFELTC--RGSVDVKGKGSMITY 1475

  Fly  1075 WLTKRQ--------------QPELTPDLISTVDTLDTYCSG-PRESMEVSVHQYCSPASNNYRLG 1124
            :|..|:              :|..|..|....:.||   || ..|.....|.:..|....:..|.
  Fly  1476 FLKGRRPIDAKELELAKTEVEPPKTLTLAKEPEKLD---SGTATEKQREQVKEQGSTEQEDDLLP 1537

  Fly  1125 S----CNCDTKCLYSRR-----SDDNVTNSHGTSE------FPKVSEPAQVNCNQLCVCRLNSSQ 1174
            |    .|.:.:.|.::|     ...|:::|.||:.      .|.:|..:.|.........|....
  Fly  1538 SPDIDMNSNMQNLTAQRRKSLCRQHNISSSFGTTVSSSTGITPSISNSSSVVTIGALPAILRGGN 1602

  Fly  1175 MFNNRGPRSAPS 1186
            ..:|..|.:..|
  Fly  1603 PLSNANPNATDS 1614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	69/389 (18%)
		PK_GC-A_B	550..832	CDD:270944	66/385 (17%)
		HNOBA	<847..886	CDD:285003	16/75 (21%)
		CYCc	865..1057	CDD:214485	66/232 (28%)
		Guanylate_cyc	892..1076	CDD:278633	64/202 (32%)
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485	28/110 (25%)
		Guanylate_cyc	722..895	CDD:278633	32/124 (26%)
		DUF1053	<949..1005	CDD:283888	20/75 (27%)
		CYCc	1259..1455	CDD:214485	62/204 (30%)
		Guanylate_cyc	1285..1479	CDD:278633	65/204 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740