DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and CG3216

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster

Alignment Length:	1147	Identity:	382/1147 - (33%)
Similarity:	576/1147 - (50%)	Gaps:	147/1147 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RSNPLAAGATVSSMRRLTDTINIGFL-AEYSQMRVTL----GGLPLAIEDVNK------NPNLLP 77
            :|..|:....|..|.......|:|.| |.:......|    ..:.||::::||      |..||
  Fly    69 KSTQLSRYTEVGEMGSTMRVYNVGVLMASHLDSPFDLERCGPAVDLALDEINKVFLKPHNITLL- 132

  Fly    78 GKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDESCTTE--ALLASAWNTPMLSFKC 140
             ||....|     ..|..|...|.|....:: .|.|||||..:...|  |.||:.||.|:::...
  Fly   133 -KKKGSYP-----SCSGARAPGLAADMYFQD-DVIAFIGPACAFALEPVARLAAYWNKPIITGMG 190

  Fly   141 SDP--------------------------IVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNK 179
            ..|                          :..:||.:.|..|......::.....|::..|:||.
  Fly   191 DQPPSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNH 255

  Fly   180 FSIVVSSKPIWGSDVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVF 244
            .:::|....::...|.:.: |....:...:|..|.::         ...:::.|.......:|..
  Fly   256 VALLVDRSELFSWTVGKNL-EYGLRQEGLLSFVKELN---------GNEEEVYENYLKDASMYAR 310

  Fly   245 IGEHIAMVDFVRGLQNRRL--------LESGDYIVVSVDDEIYDSNRRVNIMERNYLDP--YIRK 299
            :     ::..|||:..|:.        :.:|:::.:.|:           |.:..|...  :..|
  Fly   311 V-----VILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVE-----------IFQSEYWGDKGWEMK 359

  Fly   300 EKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLY 364
            ::..:..:.::.:::::|:..|.:|..:|....:::.|     |..|:....:...|..:....|
  Fly   360 DEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENA-----LYDYNYTFGEGEEVNFFIGAFY 419

  Fly   365 DSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVG 429
            |.|.:...|:.|.|..||||.||..:...::||::..|.| .|.||.|||.:.:|:::.|
  Fly   420 DGVYLLGMALNETLTEGGDIRDGVNITRRMWNRTFEGITG-HVRIDDNGDRDADYSILDL----- 478

  Fly   430 SGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIK------NDRPIQWLNGR--PPLAEPLCGFHG 486
                         .|:.    .|.||:..:..:.      :.:.|.|..||  ||...|.|||.|
  Fly   479 -------------DPIN----GKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLG 526

  Fly   487 EL--CPRKKLDWRYLVSGPLCAL-VVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNN 548
            ..  |........|.|.|.|..| :|.:.|.||.|..:..:.|..:.|:|...||.:...|.:.:
  Fly   527 NSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGS 591

  Fly   549 PTNKNIFQICRQSILVVGEPNKRS------------FTNIALFRGNIVAMKKIHKKSVDITRSIR 601
            ........:...|:...|..:.|:            :|.|..|:|..||:||::.|.||:|..:.
  Fly   592 KGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLL 656

  Fly   602 KELKLMREVRHENIINFIGASTD--HGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDIL 664
            .|:|..|:|.|||.:.|:||..|  ..:|:|.|.||:||||:|||.||.:.||..|..||:.||:
  Fly   657 WEIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIV 721

  Fly   665 KGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELL 729
            |||.|||:|::.:||.|||.|||||.|:|.:||||||..|....:........|| .|.:|||||
  Fly   722 KGMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQNYYLK-LLWIAPELL 785

  Fly   730 RDAYRPG--RGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTH 792
            .....||  ..:|:||||||||:|.|::.|.||:.:   :::::.......::.|...|||.:..
  Fly   786 PLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQE---ARQQMDVHTILHKVRQCNGFRPLIRE 847

  Fly   793 THLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQ 857
            .  :.|..:.:.:.:||.::.|.||....:|.:::.:..|...|:.|::|:.||:||.|||.||:
  Fly   848 R--ECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVE 910

  Fly   858 ERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEV 922
            |:|..|..||::|:.||||:||||||:.|..||.||.|.|..|||.|||||||||||..|:|.:|
  Fly   911 EKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDV 975

  Fly   923 VEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIR 987
            |..|||.|:..|.||..|||||||||||||:||||||..||.:||.|||.:||.:|..|.:..:|
  Fly   976 VNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLR 1040

  Fly   988 HKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVI 1052
            |||...:|:|||:|||...|||||:|||.||||||||||||||||||...:||:|.||..:|...
  Fly  1041 HKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKF 1105

  Fly  1053 GSYVCIERGLTSIKGKGDMRTYWLTKRQQPEL---TPDLIST 1091
            |::...:||...:||||.:.||||....:.|.   ||.:::|
  Fly  1106 GTFQMEQRGDVELKGKGTVTTYWLNSTSEGEARPPTPQILTT 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	90/452 (20%)
		ANF_receptor	59..427	CDD:279440	85/415 (20%)
		PHA02988	534..826	CDD:165291	111/307 (36%)
		PK_GC-A_B	550..832	CDD:270944	108/297 (36%)
		HNOBA	<847..886	CDD:285003	23/38 (61%)
		CYCc	865..1057	CDD:214485	119/191 (62%)
		Guanylate_cyc	892..1076	CDD:278633	111/183 (61%)
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	93/467 (20%)
		ANF_receptor	107..479	CDD:279440	84/429 (20%)
		PKc_like	616..885	CDD:304357	105/274 (38%)
		TyrKc	627..877	CDD:197581	104/255 (41%)
		HNOBA	<882..939	CDD:285003	29/56 (52%)
		CYCc	918..1109	CDD:214485	119/190 (63%)
		Guanylate_cyc	945..1131	CDD:278633	113/185 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	P	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.820