DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Ac3

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster

Alignment Length:	1206	Identity:	244/1206 - (20%)
Similarity:	436/1206 - (36%)	Gaps:	367/1206 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 DESCTTEA-----LLASAWNTPMLSF-KCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFH 176
            |:|..|..     |||....|.:|.. :.||.....:  ||.....:.|.:      :.||:..|
  Fly    90 DQSAPTRVINCCMLLAYLALTALLHIGRRSDKPALRR--FHQILLIIVPRA------LWLLSILH 146

  Fly   177 WNKFSIVVSSKPIWGSDVARAIQELAEARNF------------------TISHFKYISDYIPTTK 223
               |::.|..:|   |...|.:...|...||                  .|::|..:|  :|.
  Fly   147 ---FTVYVILQP---SFSPRDLLGWAILLNFLVYVTLPLQLIFLGLSIGCITYFICLS--LPV-- 201

  Fly   224 TLSQIDKIIEETYATTRI-----------YVFIGE--------------HIAMVDFVRGLQNRRL 263
            ..|..|.::....|...:           |.|:||              .:.||...:..:..||
  Fly   202 GYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERL 266

  Fly   264 LES--GDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKSL---DKISFRSVIKISMTYPQN 323
            |.|  ..::.:.:.:::..|:...      :...|:.:.::.|:   |.:.|.:   ||.||
  Fly   267 LLSVLPKHVAIKMREDLGSSSSEA------FKKIYMSRHENVSILYADIVGFTA---ISSTY--- 319

  Fly   324 PHIRDICSKIKD-YARKTPFLVPYHQRVFDNISVPIYGLHLY----------DSVMI-------Y 370
             ..:|:...:.: :||.......|.|     :.:.|.|...|          |..::       .
  Fly   320 -SAQDLVKMLNELFARFDRLAEKYQQ-----LRIKILGDCYYCISGAPDERPDHAVLCVHMGLSM 378

  Fly   371 VRAITEV---------LRLGGDIYDGNLVMSHIFNRSYHSIQGFDVY---------IDSNGDAE- 416
            |:||..|         :|:|  |:.|.::...:..|.:.    ||||         ::|:|.|.
  Fly   379 VKAIKYVQQKANSPVDMRVG--IHTGAVLAGILGQRQWQ----FDVYSKDVELANKMESSGKAGR 437

  Fly   417 ---GNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLA 478
               .:.|:..|..:....|:.|...:..::..|...|....|:..|              ..|.|
  Fly   438 VHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAF--------------ASPCA 488

  Fly   479 EPLCGFHGELC-PRKK----------------LDWRYLV------SGPLCALVVVVAIALLIKHY 520
            :.:.....|:. |...                ||...|:      :|....:.|.......:|..
  Fly   489 KKINETQAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLE 553

  Fly   521 RYEQTLAGLLWKVD-----MKDVTVINLGEYNNPTNKNIFQICRQ-------------------- 560
            .::|.|...|...|     .||..:..  .:.||..:.::.:.|:
  Fly   554 NFKQRLKDELVTRDGHENLTKDTNIFL--RFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLY 616

  Fly   561 SILVVGEPNKRS---FTNIAL----------------FRGNIVAMKKIHKKSVDITRSIRKELKL 606
            |.||:    .||   |.|||.                |.|      .:.|..||:::.. .::..
  Fly   617 SYLVL----PRSTLHFINIAAPLVPIAMLVVISLAESFSG------MLPKFFVDVSKRF-NDITF 670

  Fly   607 MREVRHENIINFIGASTDHGSVI---IFTTYCARGSLEDVLANEDLHLDHMFISSLVSDI---LK 665
            :||:....|...||.|    :||   .|.|:.   ..|.:::..:.::    .:||.|||   ::
  Fly   671 VRELAAIIIALTIGFS----NVIDMFFFVTFV---RTEHIVSESEFNV----TASLESDINLVVE 724

  Fly   666 GMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLR 730
            ||:              ::..|:.:.:|                                 |.:|
  Fly   725 GMV--------------TAEHLLPASFV---------------------------------EQMR 742

  Fly   731 DAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHL 795
            ||....|......:.:||:|:...|.             .|.|.....::|.  :...|..|.:.
  Fly   743 DAVPTERVLYPSYLSNFGVLILIAIA-------------VIAQLTHLTKILL--LLSIAALHCYF 792

  Fly   796 DIPDYIRKCLCQCWDEDPEVRPDI--RLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQE 858
            :|  :|.:.| ...::|.|.:|.|  |.....|. |.|.|..:.....:...::..:..:..|.|
  Fly   793 NI--FIMQDL-YALEDDFEHQPIISTRYAASGLL-LVAALALSTLARHMDHEDRVIFKWKTEVAE 853

  Fly   859 RTNLLYEEKKKTDMLLYQMLPRPVAELLKRG-----DPVEAECFDCVTILFSDIVGFTELCTTST 918
            :.....:.:::.:.|:|.:||..|||...:.     |.:.::.:..|.:||:.:..|::..:..|
  Fly   854 QKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEET 918

  Fly   919 ----PFEVVEMLNDWYTCCDSII---SNYDVYKVETIGDAYMVVSGLPLQNGSR----------H 966
                ..|.:..||:..:..|:::   ...|:.|::|||..||..||:.:|...|          |
  Fly   919 VNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSH 983

  Fly   967 AGEIASLAL---HLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTAS 1028
            ...:...||   |.|:::......|     ..|::|::.||..|||:|.:.|.|.::|:|||.||
  Fly   984 LAILVEFALELKHALQSINEQSFNH-----FVLKMGINHGPITAGVIGARKPHYDIWGNTVNVAS 1043

  Fly  1029 RMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKRQQPELTP------- 1086
            ||||||.:..|.::|.|..:|::.| |..::|||.::||||.:.|::|..:.|....|
  Fly  1044 RMESTGKAGAIQVTEETCNILRLFG-YTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVASGVVV 1107

  Fly  1087 ----DLISTVDTLDTYCS----------GPRESMEV 1108
                |..:...|.:...|          ||.:|:|:
  Fly  1108 LNGQDSSAVESTSELEASDIKMPLLKMNGPEQSLEI 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	80/423 (19%)
		ANF_receptor	59..427	CDD:279440	77/402 (19%)
		PHA02988	534..826	CDD:165291	62/343 (18%)
		PK_GC-A_B	550..832	CDD:270944	59/328 (18%)
		HNOBA	<847..886	CDD:285003	9/38 (24%)
		CYCc	865..1057	CDD:214485	62/216 (29%)
		Guanylate_cyc	892..1076	CDD:278633	62/203 (31%)
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	31/173 (18%)
		CYCc	256..453	CDD:214485	40/220 (18%)
		Guanylate_cyc	294..476	CDD:278633	39/199 (20%)
		CYCc	860..1071	CDD:214485	62/216 (29%)
		Guanylate_cyc	892..1092	CDD:278633	63/205 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453896
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740