Protein Alignment Gyc32E and Adcy1

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001100709.1
• Gene: Adcy1 / 305509
• RGDID: 1309318
• Length: 967
• Species: Rattus norvegicus
• Alignment Length: 999
• Identity: 206/999 - (20%)
• Similarity: 361/999 - (36%)
• Gaps: 323/999 - (32%)

  Fly   243 VFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKSLDK 307
            :|.|.::..| |||.|..|                   |.|:..:..||.::..:|.|......:
  Rat    67 LFFGVNMYGV-FVRILTER-------------------SQRKAFLQARNCIEDRLRLEDENEKQE 111

  Fly   308 ISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVR 372
            ....|::.           |::..::|:...|.|      :|:|..|.:     ..:|:|.|...
  Rat   112 RLLMSLLP-----------RNVAMEMKEDFLKPP------ERIFHKIYI-----QRHDNVSILFA 154

  Fly   373 AITEVLRLGGDIYDGNLV--MSHIFNRSYHSIQGFDVYIDSN--------GDAEGNYTVITLQND 427
            .|.....|........||  ::.:|.:       ||.....|        ||.  .|.|
  Rat   155 DIVGFTGLASQCTAQELVKLLNELFGK-------FDELATENHCRRIKILGDC--YYCV------ 204

  Fly   428 VGSGASIGSLAKMSMQP----------VGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLC 482
              ||.:         ||          :|....|..:.:.|...:..:..:....||     .||
  Rat   205 --SGLT---------QPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGR-----VLC 253

  Fly   483 GFHGELCPRKKLDWRYLV-SGPLCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINL-GE 545
            |..|   .||   |:|.| |..:....|:.|              |||..||.:...|:..| |:
  Rat   254 GVLG---LRK---WQYDVWSNDVTLANVMEA--------------AGLPGKVHITKTTLACLNGD 298

  Fly   546 Y----NNPTNKNIF-----------------QICRQSILVVGEPNKR-SFTNIALFRGNIVAMKK 588
            |    .:...:|.|                 :|....||...:|.|| .|..:......::..:|
  Rat   299 YEVEPGHGHERNTFLRTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRK 363

  Fly   589 IHKKSVDITRSI-------RKELKLMREVRHENIINFIGASTDHGSVIIFTT-------YCAR-- 637
            :.|..:..:..:       |:.|:    ...|.:.|....||:    :::||       |.:|
  Rat   364 MFKAEIPFSNVMTCEDDDKRRALR----TASEKLRNRSSFSTN----VVYTTPGTRVNRYISRLL 420

  Fly   638 GSLEDVLANEDLHL------------------DHMFISSLVSDI----LKGMIYLHDSEIISHGN 680
            .:.:..|...||:.                  |..|.|::|..:    |.|:|||    ::...:
  Rat   421 EARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILATLFGLIYL----LVIPQS 481

  Fly   681 LRSSNCLIDSRWVCQISDFGLH-ELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDV 744
            :.....|:.|  :|.:....|: .:...|..|....::::.|||:
  Rat   482 VAVLLLLVFS--ICFLVACTLYLHITRVQCFPGCLTIQIRTALCV-------------------- 524

  Fly   745 YSFGILLYEMIGRKG------PWGDTAYS-----------KEEIIQFVKCPEMLQHG-------- 784
             ...:|:|.:  .:|      ||..:::|           :..::..:.| |...||
  Rat   525 -FIVVLIYSV--AQGCVVSCLPWAWSSHSNSSLVVLAAGGRRTVLPALPC-ESAHHGLLCCLVGT 585

  Fly   785 ---------------VFRPALTHTH---LDIPDYIRK----------------CLCQCWDEDPEV 815
                           :....||.::   |::..|.:.                .|..|
  Rat   586 LPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPIMAILLFSC------- 643

  Fly   816 RPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTD--MLLYQML 878
                 .:.:|.:::...|:.:..         :|...|   :||.::   |:.|.|  .:|:.:|
  Rat   644 -----TLALHARQVDVRLRLDYL---------WAAQAE---EERDDM---ERVKLDNKRILFNLL 688

  Fly   879 PRPVAELLKRGDP----VEAECFDCVTILFSDIVGFT----ELCTTSTPFEVVEMLNDWYTCCDS 935
            |..||:.....:|    :..:.:..|.::|:.|..|.    ||...:...|.:.:||:.....|.
  Rat   689 PAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDE 753

  Fly   936 IISN---YDVYKVETIGDAYMVVSGLPLQNGSR-------HAGEIASLALHLLETVGNLKIRHKP 990
            ::..   .|:.|::|||..||...||....|:|       |...:|..|:.:.:.:.  :|.::.
  Rat   754 LMDKDFYKDLEKIKTIGSTYMAAVGLAPTAGTRAKKSISSHLSTLADFAIDMFDVLD--EINYQS 816

  Fly   991 TETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSY 1055
            .....||:|::.||..|||:|.:.|:|.::|:|||.||||:|||...||.::|..::||... ||
  Rat   817 YNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLNRC-SY 880

  Fly  1056 VCIERGLTSIKGKGDMRTYWLTKR 1079
            ..:.||..|:||||:|.||:|..|
  Rat   881 QFVCRGKVSVKGKGEMLTYFLEGR 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	42/224 (19%)
		PK_GC-A_B	550..832	CDD:270944	59/397 (15%)
		CYCc	865..1057	CDD:214485	63/211 (30%)
Adcy1	NP_001100709.1	AC_N	<6..139	CDD:318454	20/108 (19%)
		Guanylate_cyc	141..323	CDD:425528	48/237 (20%)
		Guanylate_cyc	706..903	CDD:425528	65/199 (33%)