Protein Alignment Gyc32E and GUCY2F

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001513.2
• Gene: GUCY2F / 2986
• HGNCID: 4691
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 1146
• Identity: 384/1146 - (33%)
• Similarity: 574/1146 - (50%)
• Gaps: 188/1146 - (16%)

  Fly     6 ASAAAFSCILVLLLLGCQRSNPLAAGATVSSMRRLTDTI--NIGFLAEYSQMRVTLGGLP----- 63
            |||....|:.:|               :|.|:.:...|:  .||.:..::...:....||
Human    28 ASAKFLWCLCLL---------------SVMSLPQQVWTLPYKIGVVGPWACDSLFSKALPEVAAR 77

  Fly    64 LAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYR-VKPLRAMTQMREAGVTAFIGPDES--CTTEA 125
            ||||.:|::|:.  ....:|:.|.:.......| :....:..||    .:.||||...  |...:
Human    78 LAIERINRDPSF--DLSYSFEYVILNEDCQTSRALSSFISHHQM----ASGFIGPTNPGYCEAAS 136

  Fly   126 LLASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIW 190
            ||.::|:..:.|:.|.:..:.||.::.||:|||....:|   :::::..|.|....::.|.:.||
Human   137 LLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRV---LVTVMKYFQWAHAGVISSDEDIW 198

  Fly   191 ---GSDVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFI-GEHIAM 251
               .:.||.|::          ||...:...:.|.:....:.|.::..:...||.:.| ..|.|:
Human   199 VHTANRVASALR----------SHGLPVGVVLTTGQDSQSMRKALQRIHQADRIRIIIMCMHSAL 253

  Fly   252 VDFVRGLQNRRLLE--------SGDYIVVSVDDEIYD---SNRRVNIMERNYLDPYIRKEKSKSL 305
            :.   |.....|||        .|.|:.|..|..:|.   .:....::..|   |.:|:
Human   254 IG---GETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRNN---PKLRE------ 306

  Fly   306 DKISFRSVIKISMTYPQNPHIR---------DICSKIKDYARKTPFLVPYHQRVFDNISVPIYGL 361
               ::.:|:.|::...:....:         :|..|::                ||.:| |::|.
Human   307 ---AYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLE----------------FDQVS-PLFGT 351

  Fly   362 HLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFD--VYIDSNGDAEGNYTVITL 424
             :|:|:....:|:...::..|.....:|| .|..|..:|   ||:  :..||||:....|.::..
Human   352 -IYNSIYFIAQAMNNAMKENGQAGAASLV-QHSRNMQFH---GFNQLMRTDSNGNGISEYVILDT 411

  Fly   425 QNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGF-HGEL 488
                       :|.:..:...  :..|....:..|    ...||.:..||||.|:..|.| .|::
Human   412 -----------NLKEWELHST--YTVDMEMELLRF----GGTPIHFPGGRPPRADAKCWFAEGKI 459

  Fly   489 CPRKKLDWRYLVSGPLCALVV--VVAIALL-IKHYRY--------EQTLAG---LLWKVDMKDVT 539
            | ...:|       |..|::|  .:.|||| |..:.|        .|.:.|   :|  :.::|||
Human   460 C-HGGID-------PAFAMMVCLTLLIALLSINGFAYFIRRRINKIQLIKGPNRIL--LTLEDVT 514

  Fly   540 VIN--LGEYNNPTNKNIFQICRQSILVVGEPNKRSF------------TNIALFRGNIVAMKKIH 590
            .||  .|..........|||  .|.:..|...:.||            :|||::.|:.|.:||..
Human   515 FINPHFGSKRGSRASVSFQI--TSEVQSGRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFS 577

  Fly   591 KKSVDITRSIRKE----LKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHL 651
            .......:||:..    .::|:::|||||...:|...|.|...|.|.:|:||||||:|.|:|:.|
Human   578 LGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKL 642

  Fly   652 DHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHE----LKAGQEEPN 712
            |.||.|||:.|::|||.|||..|.: ||.|:|.||::|.|:|.:::|:|.::    |:..:||.:
Human   643 DWMFKSSLLLDLIKGMKYLHHREFV-HGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESS 706

  Fly   713 KSELELKRALCMAPELLRDAYRPGR-GSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVK 776
            ..||     |..|||||| |.|..| ||..||||||.|::.|::.|..|:.......:|||..:|
Human   707 MEEL-----LWTAPELLR-APRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINRLK 765

  Fly   777 CPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNM 841
            .|.    .|:||.:...|  .|....:.:.|||.|..|.||....:....|....|.|.||.|:|
Human   766 KPP----PVYRPVVPPEH--APPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSM 824

  Fly   842 LSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSD 906
            |.::|:|:.|||.|::|||..|..||:||:.||.||||..|||.||:|..||.|.||.||:.|||
Human   825 LRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSD 889

  Fly   907 IVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIA 971
            |||||.:...|.|.|||::|||.||..|:||.::||||||||||||||.||||.:||||||.|||
Human   890 IVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIA 954

  Fly   972 SLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDS 1036
            :::|.:|.:||..|:||.|...|::|||:||||..|||||..|||||||||||||||||||||..
Human   955 NMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLP 1019

  Fly  1037 MRIHISEATYQLLQVIGSYVCIE-RGLTSIKGKGDMRTYWL 1076
            .|||:|.:|..:||.:.....:| ||.|.:||||...|:||
Human  1020 YRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWL 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	88/439 (20%)
		PK_GC-A_B	550..832	CDD:270944	108/302 (36%)
		CYCc	865..1057	CDD:214485	120/191 (63%)
GUCY2F	NP_001513.2	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	90/453 (20%)
		Protein Kinases, catalytic domain	545..815	CDD:473864	103/282 (37%)
		HNOBA	<824..869	CDD:462234	25/44 (57%)
		CYCc	848..1040	CDD:214485	120/191 (63%)