DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc32E and GUCY2C

DIOPT Version :9

Sequence 1:NP_001097148.1 Gene:Gyc32E / 34553 FlyBaseID:FBgn0010197 Length:1191 Species:Drosophila melanogaster
Sequence 2:NP_004954.2 Gene:GUCY2C / 2984 HGNCID:4688 Length:1073 Species:Homo sapiens


Alignment Length:1127 Identity:329/1127 - (29%)
Similarity:517/1127 - (45%) Gaps:213/1127 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 ATVSSMRRLTDTINIGFLAEYSQMRVTLGGLPLAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYR 96
            |....::.|.|.:|.|       :.:..|.|..|..:|..|...:....|.....|. ...:...
Human    46 AFAEPLKNLEDAVNEG-------LEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDC-RSSTCEG 102

  Fly    97 VKPLRAMTQMREAGVTAFIGPDESC---TTEALLASAWNTPMLS-----FKCSDPIVSNKSTFHT 153
            :..||.::..:..| ...|||  ||   |.:..|.:..:.||:|     ..|...        .|
Human   103 LDLLRKISNAQRMG-CVLIGP--SCTYSTFQMYLDTELSYPMISAGSFGLSCDYK--------ET 156

  Fly   154 FARTLAPASKVSKSVISL-------LNAFHWNKFSIVVSSKPIWGSDVARAIQELAEARNFTISH 211
            ..|.::||.|:...:::.       ...:.|:. |.|..:    |::.......| .|...::|:
Human   157 LTRLMSPARKLMYFLVNFWKTNDLPFKTYSWST-SYVYKN----GTETEDCFWYL-NALEASVSY 215

  Fly   212 FKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVD- 275
            |.:...:....:...:...|:.:....:.:.:..|.    .:|:..|:..|.: :.|.:::.|| 
Human   216 FSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGG----PEFLYKLKGDRAV-AEDIVIILVDL 275

  Fly   276 --DEIYDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHI-----RDICSKI 333
              |:.::.    |:...:|:                 ::|:.:::: |.|..:     |::....
Human   276 FNDQYFED----NVTAPDYM-----------------KNVLVLTLS-PGNSLLNSSFSRNLSPTK 318

  Fly   334 KDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRS 398
            :|:|                       |...:.::::...:...|..|.:|....  .:|.|...
Human   319 RDFA-----------------------LAYLNGILLFGHMLKIFLENGENITTPK--FAHAFRNL 358

  Fly   399 YHSIQGFD--VYIDSNGDAEGNYTVITLQNDVGS---------GASIGSLAKMSMQPVGFFAYDK 452
              :.:|:|  |.:|..||.:.  |::.|...|.:         ...:.....:.|.|.  |.: |
Human   359 --TFEGYDGPVTLDDWGDVDS--TMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPT--FTW-K 416

  Fly   453 NSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAIALL- 516
            ||.:|      ||     :.||.|....:..|              .::|   |:|:::.:||| 
Human   417 NSKLP------ND-----ITGRGPQILMIAVF--------------TLTG---AVVLLLLVALLM 453

  Fly   517 IKHYRYEQTLAGLLWK-VDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIAL-- 578
            ::.||.:..|....|. :..:::..:...|.|:.:.|.             :.:||..|...|  
Human   454 LRKYRKDYELRQKKWSHIPPENIFPLETNETNHVSLKI-------------DDDKRRDTIQRLRQ 505

  Fly   579 --FRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLE 641
              :....|.:|.:.....:.|...:.||..:.::.:.|:..|.|.......:.....||.||||.
Human   506 CKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLR 570

  Fly   642 DVLAN-----EDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGL 701
            :||.:     :...:|..|..|::.||.|||.|||.|:...||.|:|:||::|||.|.:|:|||.
Human   571 EVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGC 635

  Fly   702 HELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAY 766
            :.:           |..|:.|..|||.||.|    ..||||||||:||:..|:|.||    :|.|
Human   636 NSI-----------LPPKKDLWTAPEHLRQA----NISQKGDVYSYGIIAQEIILRK----ETFY 681

  Fly   767 S------KEEIIQFVKCPEMLQHGVFRPAL---THTHLDIPDYIRKCLCQCWDEDPEVRPDIRLV 822
            :      .|:|.:......|..   |||.|   |....::..|:  .:..||:||||.|||.:.:
Human   682 TLSCRDRNEKIFRVENSNGMKP---FRPDLFLETAEEKELEVYL--LVKNCWEEDPEKRPDFKKI 741

  Fly   823 RMHLKELQAGL-----KPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPV 882
            ...|.:: .||     ..:..|.::..::.|:.|||.||:|||.|...|:.:.|.|.:.:|||.|
Human   742 ETTLAKI-FGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLV 805

  Fly   883 AELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVET 947
            .:.||....||.|.::.|||.||||||||.:|..|||.|||:||||.|...|.|:.::|||||||
Human   806 VKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVET 870

  Fly   948 IGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQ 1012
            |||||||.||||.:||:|||.:||.:||.:|..:|..::.|.|...:.:|||||||||||||||.
Human   871 IGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGI 935

  Fly  1013 KMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIE-RGLTSIKGKGDMRTYWL 1076
            ||||||||||||||||||||||..:|||:|.:|..:|:........| ||.|.:||:|:..||||
Human   936 KMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWL 1000

  Fly  1077 T--KRQQPEL-TPDLISTVDTL 1095
            |  |.|:..| ||..:.....|
Human  1001 TGMKDQKFNLPTPPTVENQQRL 1022

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc32ENP_001097148.1 PBP1_Speract_GC_like 44..448 CDD:107365 70/437 (16%)
ANF_receptor 59..427 CDD:279440 65/392 (17%)
PHA02988 534..826 CDD:165291 92/309 (30%)
PK_GC-A_B 550..832 CDD:270944 91/299 (30%)
HNOBA <847..886 CDD:285003 17/38 (45%)
CYCc 865..1057 CDD:214485 111/191 (58%)
Guanylate_cyc 892..1076 CDD:278633 111/184 (60%)
GUCY2CNP_004954.2 PBP1_GC_C_enterotoxin_receptor 35..415 CDD:107364 74/451 (16%)
PK_GC-C 480..750 CDD:270946 93/307 (30%)
Pkinase_Tyr 502..745 CDD:285015 86/266 (32%)
CYCc 788..979 CDD:214485 111/190 (58%)
Guanylate_cyc 815..1002 CDD:278633 113/186 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D123766at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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