DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_037302.1	Gene:	Gucy2c / 25711	RGDID:	2771	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	1080	Identity:	333/1080 - (30%)
Similarity:	498/1080 - (46%)	Gaps:	217/1080 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LRAMTQMREAGVTAFIGPDESC---TTEALLASAWNTPMLS-----FKCSDPIVSNKSTFHTFAR 156
            ||.:|:.|:.| ...:||  ||   |.:..|.:..|.||:|     ..|...        .|..|
  Rat   105 LREITRDRKMG-CVLMGP--SCTYSTFQMYLDTELNYPMISAGSFGLSCDYK--------ETLTR 158

  Fly   157 TLAPASKVSKSVISL-------LNAFHWNKFSIVVS-SKP---IWGSDVARAIQELAEARNFTIS 210
            .|.||.|:...::..       ...|.||...:..: |:|   .|..:...|          .:|
  Rat   159 ILPPARKLMYFLVDFWKVNNAPFKTFSWNSSYVYKNGSEPEDCFWYLNALEA----------GVS 213

  Fly   211 HFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVD 275
            :|..:..:....:...|..:|:......:.:.|..|......: |:|    .|..:.|.:|:.||
  Rat   214 YFSEVLSFKDVLRRSEQFQEILMGRNRKSNVIVMCGTPETFYN-VKG----DLKVADDTVVILVD 273

  Fly   276 DEIYDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKT 340
                       :...:|.:...|  ..:.:|.:       :.:|.|....|.:.....:..:.::
  Rat   274 -----------LFSNHYFEDDTR--APEYMDNV-------LVLTLPPEKFIANASVSGRFPSERS 318

  Fly   341 PFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSI--Q 403
            .|.:.|.:...      ::| |:..:.                :.:|..|.:..|.|::.::  |
  Rat   319 DFSLAYLEGTL------LFG-HMLQTF----------------LENGESVTTPKFARAFRNLTFQ 360

  Fly   404 GFD--VYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYD--KNSVIPEFRYIKN 464
            |.:  |.:|.:||.:....::.:..|...       .|:.|      |||  ||..||    :..
  Rat   361 GLEGPVTLDDSGDIDNIMCLLYVSLDTRK-------YKVLM------AYDTHKNQTIP----VAT 408

  Fly   465 DRPIQWLNGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAIALLI-KHYRYEQTLAG 528
            .....|.|.|.|...|..|      |:..:...:.::|   .:||::.||||: :.||.:..|..
  Rat   409 SPNFIWKNHRLPNDVPGLG------PQILMIAVFTLTG---IVVVLLLIALLVLRKYRRDHELRQ 464

  Fly   529 LLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIAL----FRGNI--VAMK 587
            ..|               ::..::|||.:         |.|:.:..::.:    .|..|  |...
  Rat   465 KKW---------------SHIPSENIFPL---------ETNETNHVSLKIDDDRRRDTIQRVRQC 505

  Fly   588 KIHKKSV----------DITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLED 642
            |..||.|          :.:...:.||..:.:..:.|:..|.|.......:.....||.||||.:
  Rat   506 KYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLRE 570

  Fly   643 VLAN-----EDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLH 702
            ||.:     :...:|..|..|:::||.|||.|||.|:|..||.|:|:||::|||.|.:|:|||.:
  Rat   571 VLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCN 635

  Fly   703 ELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYS 767
            .:           |..|:.|..|||.||.|    ..|||||||||.|:..|:|.||    :|.|:
  Rat   636 SI-----------LPPKKDLWTAPEHLRQA----TISQKGDVYSFSIIAQEIILRK----ETFYT 681

  Fly   768 ------KEEIIQFVKCPEMLQHGV--FRPAL---THTHLDIPDYIRKCLCQCWDEDPEVRPDIRL 821
                  .|:|.:...     .:|.  |||.|   |....::..|:  .:..||:||||.|||.:.
  Rat   682 LSCRDQNEKIFRVEN-----SYGTKPFRPDLFLETADEKELEVYL--LVKSCWEEDPEKRPDFKK 739

  Fly   822 VRMHLKELQAGL-----KPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRP 881
            :...|.:: .||     ..:..|.::..::.|:.|||.||:|||.|...|:.:.|.|.:.:|||.
  Rat   740 IESTLAKI-FGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRL 803

  Fly   882 VAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVE 946
            |.:.||....||.|.::.|||.||||||||.:|..|||.|||:||||.|...|.|:.::||||||
  Rat   804 VVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVE 868

  Fly   947 TIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVG 1011
            ||||||:|.||||::||:|||.:|:.:||.:|..:|..::.|.|...|.:|||||||||||||||
  Rat   869 TIGDAYVVASGLPMRNGNRHAVDISKMALDILSFMGTFELEHLPGLPVWIRIGVHSGPCAAGVVG 933

  Fly  1012 QKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIE-RGLTSIKGKGDMRTYW 1075
            .||||||||||||||||||||||..:|||:|.:|..:|:........| ||.|.:||:|...|||
  Rat   934 IKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQFLYEVRGETYLKGRGTETTYW 998

  Fly  1076 LT--KRQQPEL-TPDLISTVDTLDTYCSGPRESMEVSVHQ 1112
            ||  |.|:..| ||..:.....|.|..|    .|.||..|
  Rat   999 LTGMKDQEYNLPTPPTVENQQRLQTEFS----DMIVSALQ 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	65/370 (18%)
		ANF_receptor	59..427	CDD:279440	62/349 (18%)
		PHA02988	534..826	CDD:165291	95/323 (29%)
		PK_GC-A_B	550..832	CDD:270944	96/313 (31%)
		HNOBA	<847..886	CDD:285003	17/38 (45%)
		CYCc	865..1057	CDD:214485	110/191 (58%)
		Guanylate_cyc	892..1076	CDD:278633	110/184 (60%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141	72/394 (18%)
		PKc_like	479..749	CDD:304357	93/296 (31%)
		STYKc	501..744	CDD:214568	88/268 (33%)
		CYCc	787..978	CDD:214485	110/190 (58%)
		Guanylate_cyc	814..1001	CDD:278633	112/186 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820