DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Npr3

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	XP_006232107.1	Gene:	Npr3 / 25339	RGDID:	3196	Length:	652	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	119/547 - (21%)
Similarity:	224/547 - (40%)	Gaps:	90/547 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SCILVLLLLGCQRSNPLAAGAT-------VSSMRRLTDTI-------------NIGFLAEYSQMR 56
            :|:|:...|       ||.||:       ..:.||..:.:             :..:|...:::|
  Rat   127 ACVLLARAL-------LAGGASSGGGDTGPGNRRREREALAAQKIEVLVLLPRDDSYLFSLARVR 184

  Fly    57 VTLGGLPLAIEDVNKNPNLL-PGKK--LAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGP- 117
            ..:.....::|.......|| ||.:  :|::..|.|::.....|..:.|   .|.|.....:||
  Rat   185 PAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAA---ARGAKPDLILGPV 246

  Fly   118 -DESCTTEALLASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPA-SKVSKSVISLLNAFHWNKF 180
             :.:....|.|||.|:.||||.........:|.|.::....:||| :|:.:.:::|....||::.
  Rat   247 CEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRA 311

  Fly   181 SIVVSSKPIWGS--DVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYV 243
            :::.|...:..:  .....:.|:.:......|.:.:     ..||.| .:|.|:.....:.|:.:
  Rat   312 ALLYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNF-----DETKDL-DLDDIVRYIQGSERVVI 370

  Fly   244 FIGEHIAMVDFVRGLQ---NRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLD-PYIRKEKSKS 304
            .    .|..|.:|.:.   :|..:.||||...::  |:::|:        :|.| .:.|.:|...
  Rat   371 M----CASGDTIRRIMLAVHRHGMTSGDYAFFNI--ELFNSS--------SYGDGSWKRGDKHDF 421

  Fly   305 LDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMI 369
            ..|.::.|:..:::.....|.......::|....|...      ...|.:::.:.|.|  |::::
  Rat   422 EAKQAYSSLQTVTLLRTAKPEFEKFSMEVKSSVEKQGL------NEEDYVNMFVEGFH--DAILL 478

  Fly   370 YVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITL-QNDVGSGAS 433
            ||.|:.||||.|....||..::...:||::..|.| .|.||:|||..|:::|:.: ..:.|:...
  Rat   479 YVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAG-QVSIDANGDRYGDFSVVAMTDTEAGTQEV 542

  Fly   434 IGSLAKMSMQPVGFFAYDKNSVIP----EFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKL 494
            ||..    ....|.|....|...|    :.| |...|.::..|..|      |...|.|   ::.
  Rat   543 IGDY----FGKEGRFKMRSNVKYPWGSLKLR-IDETRIVEHTNSSP------CKSSGGL---EES 593

  Fly   495 DWRYLVSGPLCALVVVVAIALLIKHYR 521
            ....:|.|.|....:::|.....|.||
  Rat   594 AVTGIVVGALLGAGLLMAFYFFRKKYR 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	92/429 (21%)
		ANF_receptor	59..427	CDD:279440	86/380 (23%)
		PHA02988	534..826	CDD:165291
		PK_GC-A_B	550..832	CDD:270944
		HNOBA	<847..886	CDD:285003
		CYCc	865..1057	CDD:214485
		Guanylate_cyc	892..1076	CDD:278633
Npr3	XP_006232107.1	PBP1_NPR_C_like	165..556	CDD:107381	93/426 (22%)
		ANF_receptor	182..535	CDD:279440	87/384 (23%)
		TM_EphA1	587..618	CDD:214014	6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810