DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001257640.1	Gene:	Gucy1b2 / 25206	RGDID:	2770	Length:	742	Species:	Rattus norvegicus

Alignment Length:	730	Identity:	201/730 - (27%)
Similarity:	298/730 - (40%)	Gaps:	202/730 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   596 ITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLAN---------EDLHL 651
            ||..:.:|...:.:|..|.|:...|.        .|..:|.....:.:|..         |:|..
  Rat    45 ITIKLIQEACKVLDVSMEAILKLFGE--------YFFKFCKMSGYDRMLRTLGGNLTEFIENLDA 101

  Fly   652 DHMFI----------SSLVSDILKGMIYLH---DSEIISH---GNLRS-SNCLIDSRWVCQISDF 699
            .|.::          |..|.:...|.:.||   |...:.|   |.:.: :....|:.....|.|.
  Rat   102 LHSYLALSYQEMNAPSFRVEEGADGAMLLHYYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSILDM 166

  Fly   700 GLHELKAGQEE------PNKSELELKRALCMAPE---------------LLRDAYR-------PG 736
            .....:.|::|      ..|:..:::.|....|:               |||...|       ||
  Rat   167 NEEVERTGKKEHVVFLVVQKAHRQIRGAKASRPQGSEDSQADQEALQGTLLRMKERYLNIPVCPG 231

  Fly   737 RGSQKGDVYSFGILLYEMIGRKGPWGDT--------AYSKEEIIQFVKCPEMLQHGVFRPAL--T 791
            ..|     :|..:....:.| |||..||        .:.:||:.    |.....|.||..||  .
  Rat   232 EKS-----HSTAVRASVLFG-KGPLRDTFQPVYPERLWVEEEVF----CDAFPFHIVFDEALRVK 286

  Fly   792 HTHLDIPDYIRKCLCQ----------------------C-------------------------- 808
            ...::|..|:...|.|                      |
  Rat   287 QAGVNIQKYVPGILTQKFALDEYFSIIHPQVTFNISSICKFINSQFVLKTRKEMMPKARKSQPML 351

  Fly   809 -------WDE---------DPEVR--PDIRLVRMHLKELQAGLKPN------IFDNMLSIME-KY 848
                   |.|         .|::|  .::...:|||.:    :.|:      |..|...:.| :.
  Rat   352 KLRGQMIWMESLRCMIFMCSPKLRSLQELEESKMHLSD----IAPHDTTRDLILLNQQRLAEMEL 412

  Fly   849 AYNLEGLVQE---RTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGF 910
            :..||...:|   .:|.|..|||||:.|||.|||..||..||.|..|.|..|:..||||||:|.|
  Rat   413 SCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVANQLKEGRKVAAGEFETCTILFSDVVTF 477

  Fly   911 TELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLAL 975
            |.:|....|.::|.|||..|:..|.:.|.:|||||||||||||||.|:|:...| ||..:|:.||
  Rat   478 TNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIGDAYMVVGGVPVPVES-HAQRVANFAL 541

  Fly   976 HLLETVGNLKIRHKPT-ETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRI 1039
            .:  .:...::.:..| |.:|:|:|:|:||..|||||.||||||||||||||||||||.|...::
  Rat   542 GM--RISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKV 604

  Fly  1040 HISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKRQQPELTPDLISTVDTLDTYCSGPRE 1104
            |:|...::.|:..| :..:.||...:||||.|.||:|.:        :|.:|.|.:....|.|.:
  Rat   605 HLSPTAHRALKNKG-FEIVRRGEIEVKGKGKMTTYFLIQ--------NLNATEDEIMGRPSAPAD 660

  Fly  1105 SMEVSVHQYCSPASNNYRLGSCNCDTKCLYSRRSDDNVTNSHGTSEFPKVSEPAQVNCNQLC--- 1166
            ..||     |:|.:.               .|:|.....|:....:..| .:||..: |::.
  Rat   661 GKEV-----CTPGNQ---------------VRKSPAVPRNTDHQQQVYK-GDPADAS-NEVTLAG 703

  Fly  1167 --VCRLNSSQMFNNR 1179
              |...||:...||:
  Rat   704 SPVAGRNSTDAVNNQ 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	61/359 (17%)
		PK_GC-A_B	550..832	CDD:270944	63/365 (17%)
		HNOBA	<847..886	CDD:285003	18/41 (44%)
		CYCc	865..1057	CDD:214485	98/192 (51%)
		Guanylate_cyc	892..1076	CDD:278633	91/184 (49%)
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002	22/125 (18%)
		HNOBA	267..453	CDD:285003	41/193 (21%)
		CYCc	432..622	CDD:214485	98/193 (51%)
		Guanylate_cyc	459..642	CDD:278633	92/186 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810