DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_036901.2	Gene:	Gucy1b1 / 25202	RGDID:	2769	Length:	619	Species:	Rattus norvegicus

Alignment Length:	637	Identity:	172/637 - (27%)
Similarity:	257/637 - (40%)	Gaps:	187/637 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 INLGEYNNPTNKNIFQICRQS-----ILVVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITRSI 600
            :|.||......|..|..|::|     :.|:|       :|:..|..|:.|   :|.....|...:
  Rat    61 LNAGEILQMFGKMFFVFCQESGYDTILRVLG-------SNVREFLQNLDA---LHDHLATIYPGM 115

  Fly   601 RKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILK 665
            |..             :|.....:.|..:|...|..|..|:|:                |..|:|
  Rat   116 RAP-------------SFRCTDAEKGKGLILHYYSEREGLQDI----------------VIGIIK 151

  Fly   666 GMI-YLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELL 729
            .:. .:|.:|             ||.:.:.|.|:...|.....:|:.:|.|           :..
  Rat   152 TVAQQIHGTE-------------IDMKVIQQRSEECDHTQFLIEEKESKEE-----------DFY 192

  Fly   730 RDAYR-PGRGSQKGDV--YSF-------------------GILLYEMIGRKGPWGDTAYSKEEII 772
            .|..| ...|:|...:  |:|                   |..:|.::.:..|.
  Rat   193 EDLDRFEENGTQDSRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPG----------- 246

  Fly   773 QFVKCPEMLQHGVFRPALTHTHLDIPDY--------------------IRKCLCQCWDEDPEVRP 817
               ||..:....:.||     |:||..:                    :.|..|    ||.....
  Rat   247 ---KCSLLSVFSLVRP-----HIDISFHGILSHINTVFVLRSKEGLLDVEKLEC----EDELTGA 299

  Fly   818 DIRLVRM-----HLKELQAGL---KPNIF----------------------DNML---SIMEKYA 849
            :|..:|:     :|.|..:.|   .|::.                      |.:|   ...|:|.
  Rat   300 EISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYK 364

  Fly   850 YNLE-GLVQERTNL----LYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVG 909
            ...| .::.:|..|    |.:||||||.|||.:||..||..|:...||.|:.:|.||||||.|||
  Rat   365 LTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVG 429

  Fly   910 FTELCTTSTPFE----VVEMLNDWYTCCDSII---SNYDVYKVETIGDAYMVVSGLPLQNGSRHA 967
            |...|:.....|    :|.:|||.||..|::.   .|..||||||:||.||.||||| :....||
  Rat   430 FNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLP-EPCIHHA 493

  Fly   968 GEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMES 1032
            ..|..|||.::|..|.:::   ..|:||:.||:|:|....||:||:||||||||:|||..||.|:
  Rat   494 RSICHLALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTET 555

  Fly  1033 TGDSMRIHISEATYQLLQVIGS----YVCIERGLTSIKGKGDMRTYWLTKRQ 1080
            ||:..:|::||.||:.|....:    :....||..|:|||.:....|...|:
  Rat   556 TGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRK 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	58/337 (17%)
		PK_GC-A_B	550..832	CDD:270944	57/334 (17%)
		HNOBA	<847..886	CDD:285003	18/43 (42%)
		CYCc	865..1057	CDD:214485	94/202 (47%)
		Guanylate_cyc	892..1076	CDD:278633	85/194 (44%)
Gucy1b1	NP_036901.2	HNOB	2..166	CDD:285002	30/156 (19%)
		HNOBA	207..406	CDD:285003	43/221 (19%)
		CYCc	385..584	CDD:214485	94/202 (47%)
		Guanylate_cyc	412..605	CDD:278633	86/196 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810