DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	1176	Identity:	370/1176 - (31%)
Similarity:	569/1176 - (48%)	Gaps:	191/1176 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GPCASAAAFSCIL----VLLLLGCQRSNPLAAGATVSSMRRLTDTINIGFLA------EYSQMRV 57
            |...|.|..|.::    |::|:.|..:..|                .:||.|      .:|..|
  Rat    20 GGAESHAGHSSLVLTLFVVMLMTCLEAAKL----------------TVGFHAPWNISHPFSVQR- 67

  Fly    58 TLG-GLPLAIEDVNKNPNLLPGK---KLAFKPVDIGHKMSAYRVKPLRA-MTQMREAGVTAFIGP 117
             || ||.:|::.:|..| :.||.   :..:.......|.|      |.| :.|::...::..|||
  Rat    68 -LGAGLQIAVDKLNSEP-VGPGNLSWEFTYTNATCNAKES------LAAFIDQVQREHISVLIGP 124

  Fly   118 --DESCTTEALLASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKF 180
              .|:.....||||.|:.|:..|......:.:.....|....:.|..::...:...|....|...
  Rat   125 ACPEAAEVIGLLASEWDIPLFDFVGQMTALEDHFWCDTCVTLVPPKQEIGTVLRESLQYLGWEYI 189

  Fly   181 SIV--VSSKPIWG--SDVARAIQELAEARNFTI-SHFKYISDYIPTTKTLSQIDKIIEETYATTR 240
            .:.  .|:...||  :::.:|:::..:. :||| :..:|.|.:      ...:.:.:....:..|
  Rat   190 GVFGGSSAGSSWGEVNELWKAVEDELQL-HFTITARVRYSSGH------SDLLQEGLRSMSSVAR 247

  Fly   241 IYVFI-----GEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKE 300
            :.:.|     .:||.......||.:|      :::.:.:..           :|.::....:.::
  Rat   248 VIILICSSEDAKHILQAAEDLGLNSR------EFVFLLLQQ-----------LEDSFWKEVLAED 295

  Fly   301 KSKSLDKISFRSVIKIS-MTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLY 364
            |.....|: :.||..|: .||..:....|...::....|:.||    ...:.....|..|..:|:
  Rat   296 KVTRFPKV-YESVFLIAPSTYGGSAGDDDFRKQVYQRLRRPPF----QSSISSEDQVSPYSAYLH 355

  Fly   365 DSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGF--DVYIDSNGDAEGNYTVITLQND 427
            |::::|.:.:.|:::...|..||..::|.: .....::||.  .|.:|:.|....:|:|..||..
  Rat   356 DALLLYAQTVEEMMKAEKDFRDGRQLISTL-RADQVTLQGITGPVLLDAQGKRHMDYSVYALQKS 419

  Fly   428 VGSGASIGSLAKMSMQPVGFFAYDK-NSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPR 491
             |:|:..          :.|..||. ..||..:|   :|......:|..|..:|.||||.:||..
  Rat   420 -GNGSRF----------LPFLHYDSFQKVIRPWR---DDLNASGPHGSHPEYKPDCGFHEDLCRT 470

  Fly   492 KKLDWRYLVSG-----PLCALVVVVAIALLIKHYRYEQTLAGL-LWKVDMKDVTVINLGEYNNPT 550
            |......:.:.     |...|:||.:.|          .:.|| ||::         .|:..|..
  Rat   471 KPPTGAGMTASVTAVIPTVTLLVVASAA----------AITGLMLWRL---------RGKVQNHP 516

  Fly   551 NKNIFQICRQSILVV--------GEPNKR----------------SFTN-----------IALFR 580
            ....:||...||.::        |.|..|                ||..           :.|::
  Rat   517 GDTWWQIHYDSITLLPQHKPSHRGTPMSRCNVSNASTVKISADCGSFAKTHQDEELFYAPVGLYQ 581

  Fly   581 GNIVAMKKIHKKSVDITR--SIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDV 643
            ||.||:..|.:::....:  ::.:|:.||.|::||||:.|.|..|:..::.|.|..|.:|||:||
  Rat   582 GNHVALCYIGEEAEARIKKPTVLREVWLMCELKHENIVPFFGVCTEPPNICIVTQCCKKGSLKDV 646

  Fly   644 LANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAG- 707
            |.|.|..:|.:|..|.|.||:.||::||.|.:.|||||:.||||:||....:::.|||.|.|.|
  Rat   647 LRNSDHEMDWIFKLSFVYDIVNGMLFLHGSPLRSHGNLKPSNCLVDSHMQLKLAGFGLWEFKHGS 711

  Fly   708 ------QEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRK--GPWGDT 764
                  ||..:.|||     ...||||||....|..|:.:||||||.|||.::|.::  ||:.|.
  Rat   712 TCRIYNQEATDHSEL-----YWTAPELLRLRELPWSGTPQGDVYSFAILLRDLIHQQAHGPFEDL 771

  Fly   765 AYSKEEIIQFVK---CPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHL 826
            ..:.||||..:|   .|..|     ||:|.....|  :.|...:..||.|.||.||....::..|
  Rat   772 EAAPEEIISCIKDSRAPVPL-----RPSLLEDKGD--ERIVALVRACWAESPEQRPAFPSIKKTL 829

  Fly   827 KELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDP 891
            :|.....:.:|.|:|:..:|.||.:||.:|:|||..|..||:|.:.||..|||..|.|.|..|..
  Rat   830 REASPRGRVSILDSMMGKLEMYASHLEEVVEERTCQLVAEKRKVEKLLSTMLPSFVGEQLIAGKS 894

  Fly   892 VEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVS 956
            ||.|.|:.|||.||||||||:||:.|:|.:||::|||.|:..|..|..:||||||||||||||.|
  Rat   895 VEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQTHDVYKVETIGDAYMVAS 959

  Fly   957 GLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFG 1021
            |||::||::||.|||:::||||....|.:|.|.|.|.::||||:|:||..|||||..||||||||
  Rat   960 GLPIRNGAQHADEIATMSLHLLSVTTNFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFG 1024

  Fly  1022 DTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKRQ-----Q 1081
            ||||.||||||:...:|||:|::|.:.|.|.|.|...:||..|:||||:..|:|||.:.     .
  Rat  1025 DTVNMASRMESSSLPLRIHVSQSTARALLVAGGYHLQKRGTISVKGKGEQTTFWLTGKDGFAVPL 1089

  Fly  1082 PELTPD 1087
            ||.|.:
  Rat  1090 PEFTEE 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	83/429 (19%)
		ANF_receptor	59..427	CDD:279440	76/387 (20%)
		PHA02988	534..826	CDD:165291	112/340 (33%)
		PK_GC-A_B	550..832	CDD:270944	112/330 (34%)
		HNOBA	<847..886	CDD:285003	19/38 (50%)
		CYCc	865..1057	CDD:214485	112/191 (59%)
		Guanylate_cyc	892..1076	CDD:278633	108/183 (59%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	87/438 (20%)
		ANF_receptor	66..417	CDD:279440	75/389 (19%)
		PK_GC	558..832	CDD:270894	104/285 (36%)
		CYCc	868..1058	CDD:214485	111/189 (59%)
		Guanylate_cyc	895..1081	CDD:278633	110/185 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780