DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Gucy2f

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001007577.1	Gene:	Gucy2f / 245650	MGIID:	105119	Length:	1108	Species:	Mus musculus

Alignment Length:	1106	Identity:	369/1106 - (33%)
Similarity:	534/1106 - (48%)	Gaps:	208/1106 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 LAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDES--CTTEAL 126
            ||||.::::...  .:..:|:.|.:.......:........|...:|   |:||...  |...:|
Mouse    78 LAIERISRDKTF--DRSYSFEYVILNEDCQTSKALASFISHQQMASG---FVGPANPGFCEAASL 137

  Fly   127 LASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWG 191
            |.::|:..:.|:.|.:..:.||.:|.||:|||....:|   :::::..|.|....::.|.:.||.
Mouse   138 LGTSWDKGIFSWACVNHELDNKHSFPTFSRTLPSPIRV---LVTVMKYFQWAHAGVISSDEDIWM 199

  Fly   192 SDVARAIQELAEARNFTISHFKYISDYIPTTKTLS------QIDKIIEETYATTRIYVFI-GEHI 249
            ....|....|.             |..:|....|:      .|.|.:::.....||.:.| ..|.
Mouse   200 HTANRVSSALR-------------SQGLPVGVVLTSGRDSQSIQKALQQIRQADRIRIIIMCMHS 251

  Fly   250 AMVDFVRGLQNRRLLE--------SGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKSLD 306
            |::.   |......||        .|.|:.|..|..:|..             ||
Mouse   252 ALIG---GETQTHFLELAHDLKMTDGTYVFVPYDVLLYSL-------------PY---------- 290

  Fly   307 KISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVF------------------DN 353
            |.|...|::      .||.:|:.      |.......|..|::.|                  .|
Mouse   291 KHSPYQVLR------NNPKLREA------YDAVLTITVESHEKTFYEAYAEAAARGEIPEKPDSN 343

  Fly   354 ISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYI--DSNGDAE 416
            ...|::|. :|:|:....:|:...::..|.....:|| .|..|..::   ||:..|  ||||:..
Mouse   344 QVSPLFGT-IYNSIYFIAQAMNNAMKKNGRASAASLV-QHSRNMQFY---GFNQLIKTDSNGNGI 403

  Fly   417 GNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPL 481
            ..|.::....             ...:..|.:..|..:.:..||    ..||.:..|||..|:..
Mouse   404 SEYVILDTNG-------------KEWELRGTYTVDMETELLRFR----GTPIHFPGGRPTSADAK 451

  Fly   482 CGFHGELCPRKKLDWRYLVSGPLC------ALVVVVAIALLI-------------KHYRYEQTLA 527
            |.|    ..||           :|      ||.::|..||||             :.....|.:.
Mouse   452 CWF----AERK-----------ICQGGIDPALAMMVCFALLIALLSINGFAYFIRRRINKIQLIK 501

  Fly   528 G---LLWKVDMKDVTVIN--LGEYNNPTNKNIFQICRQSILVVGEPNKRSF------------TN 575
            |   :|  :.::|||.||  .|..........|||.  |.:..|...:.||            :|
Mouse   502 GPNRIL--LTLEDVTFINPHFGSKRGSRASVSFQII--SEVQSGRSPRLSFSSGSLTPATYENSN 562

  Fly   576 IALFRGNIVAMKKIHKKSVDITRSIRKE----LKLMREVRHENIINFIGASTDHGSVIIFTTYCA 636
            ||::.|:.|.:||.........:||:..    .::|:::||||:...:|...|.|...|.:.:|:
Mouse   563 IAIYEGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSEFCS 627

  Fly   637 RGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGL 701
            |.||||:|.|:|:.||.||.|||:.|::|||.|||..|.| ||.|:|.||::|.|:|.:::|:|.
Mouse   628 RRSLEDILTNDDVKLDWMFKSSLLLDLIKGMKYLHHREFI-HGRLKSRNCVVDGRFVLKVTDYGF 691

  Fly   702 HE----LKAGQEEPNKSELELKRALCMAPELLRDAYRPG---RGSQKGDVYSFGILLYEMIGRKG 759
            ::    |:..:|||::.||     |..||||||   .||   .||..||||||.|::.|::.|..
Mouse   692 NDILEMLRLSEEEPSEEEL-----LWTAPELLR---APGGIRLGSFAGDVYSFAIIMQEVMVRGA 748

  Fly   760 PWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYI-RKCL---CQCWDEDPEVRPDIR 820
            |:.......:|||..:|.|.    .|:||.::      |:|. .:||   .|||.|..|.||...
Mouse   749 PFCMMDLPAKEIIDRLKMPP----PVYRPVVS------PEYAPAECLQLMKQCWAEASEQRPTFD 803

  Fly   821 LVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAEL 885
            .:....|....|.|.||.|:||.::|:|:.|||.|::|||..|..||:||:.||.||||..|||.
Mouse   804 EIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPLSVAES 868

  Fly   886 LKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGD 950
            ||:|..||.|.||.||:.||||||||.:...|.|.|||::|||.||..|:||.::||||||||||
Mouse   869 LKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGD 933

  Fly   951 AYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMP 1015
            ||||.||||.:||||||.|||:::|.:|.:||..|:||.|...|::|||:||||..|||||..||
Mouse   934 AYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMP 998

  Fly  1016 RYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIE-RGLTSIKGKGDMRTYWLTKR 1079
            |||||||||||||||||||...|||:|.:|..:||.:.....:| ||.|.:||||...|:||..:
Mouse   999 RYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQTLSEGYEVELRGRTELKGKGTEETFWLVGK 1063

  Fly  1080 Q 1080
            :
Mouse  1064 K 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	83/420 (20%)
		ANF_receptor	59..427	CDD:279440	82/399 (21%)
		PHA02988	534..826	CDD:165291	113/320 (35%)
		PK_GC-A_B	550..832	CDD:270944	108/308 (35%)
		HNOBA	<847..886	CDD:285003	22/38 (58%)
		CYCc	865..1057	CDD:214485	120/191 (63%)
		Guanylate_cyc	892..1076	CDD:278633	113/184 (61%)
Gucy2f	NP_001007577.1	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	86/437 (20%)
		PKc_like	545..815	CDD:419665	103/288 (36%)
		HNOBA	<824..869	CDD:400168	25/44 (57%)
		CYCc	848..1040	CDD:214485	120/191 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4547
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770