DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	1345	Identity:	254/1345 - (18%)
Similarity:	437/1345 - (32%)	Gaps:	463/1345 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SCILVLLLLGCQRSN----PLAAGATVSSMRR-----------LTDTINIGF--LAEY------- 52
            :|::|..:..||...    ||..|......||           ...|.::.|  ||||
Mouse   211 TCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQA 275

  Fly    53 ----SQMRVTLGGLPLAIEDV-------------NKNPNLL----PGKKLAFKPVDIGHKMSAYR 96
                ||...|:.....::|:|             |...|.:    ||      .:|..||.|  :
Mouse   276 SKVVSQRMSTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPG------GLDTLHKFS--Q 332

  Fly    97 VKPLRAMTQMREAGVTAFIGPDESCTTEALLASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPA 161
            :|.|.  ....:.|:...:..:.|..||           ||..|:.        ||..      .
Mouse   333 LKGLN--LSHNKLGLFPVLLCEISTLTE-----------LSLSCNG--------FHDL------P 370

  Fly   162 SKVSKSVISLLNAFHWNKFSIVVSSKPIWGSDVARAIQELAEARNFT-----ISHFKYISDYIPT 221
            |::.|    |||          :.:..:.|:.:.....||...|..|     .:.|::|.:.:
Mouse   371 SQIGK----LLN----------LQTLSLDGNGLTALPDELGNLRQLTSLGISFNDFRHIPEVL-- 419

  Fly   222 TKTLSQIDKIIEETYATTRIYVF-IG--EHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNR 283
             :.|:.:||:   ..|..|:.|. :|  ..::.|..|....|.         :.:|..|..:.|:
Mouse   420 -EKLTMLDKV---AMAGNRLEVLNLGALTRMSQVKHVDLRMNH---------LKTVITENMEGNK 471

  Fly   284 RVNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQ 348
            .:..|:       :|..:...||   ..|:..:...:.:...:|::  .:..::.:|.: ..:::
Mouse   472 HITHMD-------LRDNQLTDLD---LSSLCSLEQLHCERNQLREL--TLSGFSLRTLY-ASWNR 523

  Fly   349 RVFDNI-SVP--IYGLHLYDSVM-----------------IYVRAITEV-LRLGGDIYDGNLVMS 392
            ....|: .||  :..|.|..:::                 |....:||| :|:...:....|::.
Mouse   524 LTAVNVYPVPSLLTSLELSQNLLECVPDWACEAKKLEILDISHNLLTEVPMRILSSLSLRKLMVG 588

  Fly   393 HIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIP 457
            |   ...|.:.....:|.        ..|:.:|::.           :|..|...|:...|
Mouse   589 H---NHIHVLPALVEHIP--------LEVLDIQHNT-----------LSRLPDTLFSKALN---- 627

  Fly   458 EFRYIKNDRPIQWLNGRPPLAEPL---CGFHGELCPRKKLDWRYLVSGPL---CALVVVVAIALL 516
                      :::||......|.|   |.....|   ..|...||.|..|   |..|:|....|.
Mouse   628 ----------LRYLNASANSLESLPSACAGEESL---SVLQLLYLTSNLLTDQCIPVLVGHPHLR 679

  Fly   517 IKHYRYEQTL---AGLLWKVDMKDVTVINLGEYNNPTNK-----NIFQICRQSILVVGEPNKRSF 573
            :.|....|..   |..|.|::       .|.|.|...||     .....|::...:|...|
Mouse   680 VLHLANNQLQTFPASKLNKLE-------QLEELNLSGNKLTAIPTTIANCKRLHTLVAHAN---- 733

  Fly   574 TNIALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGAS-TDHGSVIIFTTYCAR 637
             ||::|                            .|:.....|.|:..| .|...::|.....|.
Mouse   734 -NISIF----------------------------PEILQLPQIQFVDLSCNDLTEILIPEALPAT 769

  Fly   638 GSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEI-ISHGNLRSSNCLIDSR-WVCQISDFG 700
            ....|:..|.:|.|:|..:.          ::.|.:.: |....|.:::..:.|. |     ..|
Mouse   770 LQDLDLTGNTNLVLEHKTLD----------MFSHITALKIDQKPLPATDSAVTSTFW-----SHG 819

  Fly   701 LHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTA 765
            |.|: |||.  ||        ||:: .|..|.:..|.|:           :|.|..     ||
Mouse   820 LAEM-AGQR--NK--------LCVS-ALAMDNFAEGVGA-----------VYGMFD-----GD-- 854

  Fly   766 YSKEEIIQFVKCP------EMLQHG----VFRPALTHTHLDIPDYIRK------------CLCQC 808
             ..||:.:.::|.      |.:||.    ||   :|:|.|...   ||            .||.
Mouse   855 -RNEELPRLLQCTMADVLLEEVQHSTNDTVF---MTNTFLVSH---RKLGMAGQKLGSSALLCY- 911

  Fly   809 WDEDPEVRPD-----------IRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNL 862
                  :|||           :..|.|....|..|.||.....:.|:  ::.......|:::..:
Mouse   912 ------IRPDTADPTSSFSLTVANVGMCQAVLCRGGKPVPLSKVFSL--EHDPEEAQRVKDQKAI 968

  Fly   863 LYEEKKK------TDML----LYQ-MLPRP-VA--------ELLKRGDPV------EAECFDCVT 901
            :.|:.|.      |.:|    ||. :||:| :|        |||..|:..      ..|..:.|.
Mouse   969 ITEDNKVNGVTCCTRLLGCTYLYPWILPKPHIASTPLTIQDELLILGNKALWEHLSYLEAVNAVR 1033

  Fly   902 ILFSDIVGFTELCTTSTPF-------EVVEMLN---DWYTC------------CDSIISNYDVYK 944
            .:...:....:|||.:..:       .:|..||   :..||            ..|..:..|..|
Mouse  1034 HVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTAALKDTPK 1098

  Fly   945 VETIGDAYMVVSGLPLQ-NGSRHAGEIASLALHLLETVG-NLKIRHKPTETVQLRIGVHSGPCAA 1007
            ..|...:..:.|....: :.|..:.|:.|.|.....||| ...:..:|    :.|..:|  |.::
Mouse  1099 PTTPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNTVGLEASLLPRP----ERRCSLH--PASS 1157

  Fly  1008 GVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVI---GSYVCIERGLTSIKGKG 1069
            ..|.|:.|....|... .:.:.::|..|           |.::.:   ||.|.:|..:...:|:
Mouse  1158 AGVFQRQPSCATFSSN-QSDNGLDSDDD-----------QPVEGVITNGSRVEVEVDIHCCRGR- 1209

  Fly  1070 DMRTYWLTKRQQPELTPDLISTVDTLDTYCSGPRESMEVSVHQYCSPAS---------NNYRLGS 1125
                       :||.:|.|             |:.|......:....|.         |:..|..
Mouse  1210 -----------EPESSPPL-------------PKNSSNACSEERARGAGFGIRRQNSVNSGILLP 1250

  Fly  1126 CNCD---------TKCLYSRR--------SDDNVTNSHGTSEFPK 1153
            .|.|         |.|||.::        .:|::......:|.||
Mouse  1251 ANRDKMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEAPK 1295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	79/462 (17%)
		ANF_receptor	59..427	CDD:279440	69/413 (17%)
		PHA02988	534..826	CDD:165291	66/332 (20%)
		PK_GC-A_B	550..832	CDD:270944	64/322 (20%)
		HNOBA	<847..886	CDD:285003	12/58 (21%)
		CYCc	865..1057	CDD:214485	49/244 (20%)
		Guanylate_cyc	892..1076	CDD:278633	38/216 (18%)
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131	15/63 (24%)
		leucine-rich repeat	285..305	CDD:275380	3/19 (16%)
		leucine-rich repeat	306..332	CDD:275380	8/33 (24%)
		LRR_RI	309..548	CDD:238064	56/315 (18%)
		LRR_8	354..412	CDD:290566	18/96 (19%)
		leucine-rich repeat	356..378	CDD:275380	10/50 (20%)
		leucine-rich repeat	379..401	CDD:275380	3/21 (14%)
		leucine-rich repeat	402..424	CDD:275380	4/24 (17%)
		LRR_8	425..483	CDD:290566	14/76 (18%)
		leucine-rich repeat	425..448	CDD:275380	6/25 (24%)
		LRR_RI	447..714	CDD:238064	58/334 (17%)
		leucine-rich repeat	449..472	CDD:275380	6/31 (19%)
		leucine-rich repeat	474..493	CDD:275380	5/28 (18%)
		leucine-rich repeat	494..513	CDD:275380	1/20 (5%)
		leucine-rich repeat	514..535	CDD:275380	4/21 (19%)
		LRR_8	536..592	CDD:290566	9/58 (16%)
		leucine-rich repeat	536..558	CDD:275380	2/21 (10%)
		leucine-rich repeat	559..581	CDD:275380	5/21 (24%)
		leucine-rich repeat	582..597	CDD:275380	3/17 (18%)
		LRR_8	604..664	CDD:290566	16/87 (18%)
		leucine-rich repeat	604..627	CDD:275380	5/33 (15%)
		leucine-rich repeat	628..653	CDD:275380	6/27 (22%)
		leucine-rich repeat	654..677	CDD:275380	8/22 (36%)
		LRR_8	676..735	CDD:290566	14/70 (20%)
		leucine-rich repeat	678..701	CDD:275380	6/29 (21%)
		leucine-rich repeat	702..724	CDD:275380	6/21 (29%)
		leucine-rich repeat	747..768	CDD:275380	5/20 (25%)
		PP2Cc	816..1065	CDD:238083	65/299 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900