Protein Alignment Gyc32E and Npr2

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_776149.1
• Gene: Npr2 / 230103
• MGIID: 97372
• Length: 1047
• Species: Mus musculus
• Alignment Length: 1106
• Identity: 386/1106 - (34%)
• Similarity: 576/1106 - (52%)
• Gaps: 129/1106 - (11%)

  Fly    28 LAAGATVSSMRRLTDTI-----NIGFLAEYSQMRVTLGGLPLAIEDVNKNPNLLPGKKLAFKPVD 87
            ||.|......|.||..:     |:.:...:.::...:.   ||:|.:.:   .|| ..|.|...:
Mouse    13 LAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVA---LAVEALGR---ALP-VDLRFVSSE 70

  Fly    88 IGHKMSAYRVKPLRAMTQMREAGVTAFIGPDESC----TTEALLASAWNTPMLSF-KCSDPIVSN 147
            :....|.| :.||||:...........:||  .|    .:.|..||.|..|:|:. ..:....:.
Mouse    71 LDGACSEY-LAPLRAVDLKLYHDPDLLLGP--GCVYPAASVARFASHWRLPLLTAGAVASGFAAK 132

  Fly   148 KSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVV------SSKPIWGSDVARAIQELAEARN 206
            ...:.|..||...|.|:.:.|::|...|:|...:.::      ..:|.:.:  ...:.|..:..|
Mouse   133 NEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFT--IEGVFEALQGSN 195

  Fly   207 FTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDYIV 271
            .::.|..|..:  |...  .|....|.   |..|| |:|...:.|:..:.....|..|.:|||:.
Mouse   196 LSVQHQVYARE--PGGP--EQATHFIR---ANGRI-VYICGPLEMLHEILLQAQRENLTNGDYVF 252

  Fly   272 VSVDDEIYDSNRR---VNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKI 333
            ..:|  ::..:.|   .....|.:.|.. .:|::::| :.:|::|:.|:...|.||..::..:::
Mouse   253 FYLD--VFGESLRAGPTRATGRPWQDNR-TQEQAQAL-REAFQTVLVITYREPPNPEYQEFQNRL 313

  Fly   334 KDYARKTPFLVPYHQRVFDNISVPIYGLHL------------YDSVMIYVRAITEVLRLGGDIYD 386
            ...||:.                  :|:.|            ||.:::|.:.:.|.::.||...|
Mouse   314 LIRARED------------------FGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTRED 360

  Fly   387 GNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYD 451
            |..::..:..|.||.:.|. |.:|.|.|.|.:: |:....|:.||         ..||...::..
Mouse   361 GLRIVEKMQGRRYHGVTGL-VVMDKNNDRETDF-VLWAMGDLDSG---------DFQPAAHYSGA 414

  Fly   452 KNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVV------ 510
            :..:      ....|||.|:.|.|||..|.|.|        .||.......||..|.:|
Mouse   415 EKQI------WWTGRPIPWVKGAPPLDNPPCAF--------DLDDPSCDKTPLSTLAIVALGTGV 465

  Fly   511 ------VAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQS---ILVVG 566
                  |:..|:.:....|:.||.:||::..:::...|...|:......:....|.|   .|:..
Mouse   466 TFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSRLTLSLRGSSYGSLMTA 530

  Fly   567 EPNKRSFTNIALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIF 631
            ....:.|.|...|:||:||:|.::||.:::||.:..|||.||:|:..::..||||..|..::.|.
Mouse   531 HGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIV 595

  Fly   632 TTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQI 696
            |.||.||||:|:|.|:.::||.||..||::|::|||.:||:|.|.|||:|:||||::|||:|.:|
Mouse   596 TEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI 660

  Fly   697 SDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPW 761
            :|:||...:: ..||:.|.....:.|..|||||.....|..|.||.|||||.|:|.|:..|.||:
Mouse   661 TDYGLASFRS-TAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPF 724

  Fly   762 GDTAY------SKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIR 820
                |      |.:||:|.|:..   |...|||::..|.|:  :.:...:.:||.:||..|||..
Mouse   725 ----YLEGLDLSPKEIVQKVRNG---QRPYFRPSIDRTQLN--EELVLLMERCWAQDPTERPDFG 780

  Fly   821 LVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAEL 885
            .::..::........:|.||:|..||:||.|||.||:|||....|||:|.:.||||:||..|||.
Mouse   781 QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQ 845

  Fly   886 LKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGD 950
            ||||:.|:||.||.|||.||||||||.|...|||.:||.:|||.|||.|:||.|:||||||||||
Mouse   846 LKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGD 910

  Fly   951 AYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMP 1015
            |||||||||.:||.|||.|||.:||.||:.|.:.:|||:|.:.::||||||:||..|||||.|||
Mouse   911 AYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMP 975

  Fly  1016 RYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKRQ 1080
            |||||||||||||||||.|.:::||:|..|...|..:|.:....||...:||||.||||||...|
Mouse   976 RYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQ 1040

  Fly  1081 Q 1081
            :
Mouse  1041 K 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	90/434 (21%)
		PK_GC-A_B	550..832	CDD:270944	110/290 (38%)
		CYCc	865..1057	CDD:214485	125/191 (65%)
Npr2	NP_776149.1	PBP1_NPR_B	26..421	CDD:380607	91/453 (20%)
		PK_GC-A_B	518..792	CDD:270944	110/283 (39%)
		HNOBA	<798..846	CDD:462234	28/47 (60%)
		CYCc	825..1009	CDD:214485	123/183 (67%)