DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and Adcy2

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_705762.2	Gene:	Adcy2 / 210044	MGIID:	99676	Length:	1095	Species:	Mus musculus

Alignment Length:	1148	Identity:	240/1148 - (20%)
Similarity:	411/1148 - (35%)	Gaps:	385/1148 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 SAWNT------------PMLSFKCSDPIVSN--KSTFHTFARTL----APASK------VSKSVI 169
            |||:.            .||.|...|.|:::  .|:.||...::    .|.:|      :..:||
Mouse   136 SAWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVYLSATPGAKEHLFWQILANVI 200

  Fly   170 -----SLLNAFHWNKFSIVVSSKPIWGSDVARAIQELAEARNFTISHFKYISDYIPTTKTLSQID 229
                 :|..|:|                   :.:.|||
Mouse   201 IFICGNLAGAYH-------------------KHLMELA--------------------------- 219

  Fly   230 KIIEETYATT------RIYVFIGEHIAMVDFVRGLQNRRLLE-SGDYIVVSVDDEIYD--SNRRV 285
              :::||..|      ||         .::|.:..|.|.||. ...:|.:.:..||..  ...:.
Mouse   220 --LQQTYRDTCNCIKSRI---------KLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKA 273

  Fly   286 NIME--RNYLDPYIRKEKSKSL---DKISFRSVI-----------------KISMTYPQNPHIRD 328
            ..||  .|:.:.|:::..:.|:   |.:.|..:.                 |......:|.
Mouse   274 GQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENE---- 334

  Fly   329 ICSKIKDY------ARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEV---LRLGGDI 384
             |.:||..      ....|..:|.|.:     :....||.:.:::. .||..|.|   :|:|  :
Mouse   335 -CMRIKILGDCYYCVSGLPISLPNHAK-----NCVKMGLDMCEAIK-KVRDATGVDINMRVG--V 390

  Fly   385 YDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIG--SLAKMSMQPVGF 447
            :.||::...|..:.:.    :||:...          :||.|.:.:|...|  .::.::::.:.
Mouse   391 HSGNVLCGVIGLQKWQ----YDVWSHD----------VTLANHMEAGGVPGRVHISSVTLEHLN- 440

  Fly   448 FAYDKNSVIPEFR--YIKND--RPIQWLNGRPPLAEPLCGFHGELCPRKKLD----------WRY 498
            .||.......|.|  |:|..  :....:|.:.....|...|.    ||..||          .||
Mouse   441 GAYKVEEGDGEIRDPYLKQHLVKTYFVINPKGERRSPQHLFR----PRHTLDGAKMRASVRMTRY 501

  Fly   499 LVSGPLCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYN-------NPTNKNIFQ 556
            |.|.         ..|....|..:..::.....|:...||.   :|::|       ..:.|..|:
Mouse   502 LESW---------GAAKPFAHLHHRDSMTTENGKISTTDVP---MGQHNFQNRTLRTKSQKKRFE 554

  Fly   557 ICRQSILVVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITR--------SIRKELKL------- 606
                     .|.|:|....|    ..|.|.|: ..||.||.|        :|.||.:.
Mouse   555 ---------EELNERMIQAI----DGINAQKQ-WLKSEDIQRISLFFYNKNIEKEYRATALPAFK 605

  Fly   607 -----------------MREVRHENIINF-IGASTDHGSVIIFTTYCARGSL------------- 640
                             :..:...:|:.| .||:  ..|:|.....|..|.|
Mouse   606 YYVTCACLIFLCIFIVQILVLPKTSILGFSFGAA--FLSLIFILFVCFAGQLLQCSKKASASLLW 668

  Fly   641 ----EDVLANED---LHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISD 698
                ..::||..   :.|..:..:.:::..:..|.:|.:||..:.....:||..:      .:.|
Mouse   669 LLKSSGIIANRPWPRISLTIVTTAIILTMAVFNMFFLSNSEETTLPTANASNANV------SVPD 727

  Fly   699 FGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYS--FGILLYEMIGRKGPW 761
                         |::.:...|.|...|..               :||  .|::...:..|
Mouse   728 -------------NQTAILHARNLFFLPYF---------------IYSCILGLISCSVFLR---- 760

  Fly   762 GDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHL 826
              ..|..:.:|..|   .::.:.:.   |.|||..:.|...:.|.|        ||.|      .
Mouse   761 --VNYELKMLIMMV---ALVGYNII---LLHTHAHVLDAYSQVLFQ--------RPGI------W 803

  Fly   827 KELQ--AGLKPNIFDNMLSIM----EKYAYNLEGLVQERTNLLYEEKKKTD------------ML 873
            |:|:  ..:..:||...|.::    |.|.         |.:.|::.|.|.:            :|
Mouse   804 KDLKTMGSVSLSIFFITLLVLGRQSEYYC---------RLDFLWKNKFKKEREEIETMENLNRVL 859

  Fly   874 LYQMLPRPVAE-LLKR---GDPVEAECFDCVTILFSDIVGFTELCTTS----TPFEVVEMLNDWY 930
            |..:||..||| .|.|   .:.:..:.:|||.::|:.|..|.|..|.|    ...|.:.:||:
Mouse   860 LENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNE-- 922

  Fly   931 TCCDSIISNYD----------VYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHL-------L 978
                 ||:::|          |.|::|||..||..:||.......||.|.....:|:       .
Mouse   923 -----IIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHAQEPERQYMHIGTMVEFAY 982

  Fly   979 ETVGNLKIRHKPT-ETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHIS 1042
            ..||.|...:|.: ...:||:|::.||..|||:|.:.|:|.::|:|||.||||:|||...:|.::
Mouse   983 ALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVT 1047

  Fly  1043 EATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKRQQPELT 1085
            |.|..:||.:| |.|..||:.::|||||::||::.......|:
Mouse  1048 EETSLILQTLG-YTCTCRGIINVKGKGDLKTYFVNTEMSRSLS 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	67/389 (17%)
		ANF_receptor	59..427	CDD:279440	64/366 (17%)
		PHA02988	534..826	CDD:165291	61/353 (17%)
		PK_GC-A_B	550..832	CDD:270944	59/338 (17%)
		HNOBA	<847..886	CDD:285003	12/51 (24%)
		CYCc	865..1057	CDD:214485	72/229 (31%)
		Guanylate_cyc	892..1076	CDD:278633	71/205 (35%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831	32/184 (17%)
		CYCc	240..443	CDD:214485	40/230 (17%)
		Guanylate_cyc	285..469	CDD:278633	36/211 (17%)
		DUF1053	499..603	CDD:283888	28/129 (22%)
		CYCc	852..1060	CDD:214485	69/215 (32%)
		Guanylate_cyc	882..1081	CDD:278633	71/206 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810